Citation: Yu-Hui Zhang, Ye Tian, Xianliang Sheng, Chen-Shuang Liu, Lu-Qiang Wei, Jie Wang, Yong Chen. Construction of a black phosphorous-based noncovalent multiple nanosupramolecular assembly for synergistic targeted photothermal and chemodynamic therapy[J]. Chinese Chemical Letters, ;2025, 36(4): 110193. doi: 10.1016/j.cclet.2024.110193 shu

Construction of a black phosphorous-based noncovalent multiple nanosupramolecular assembly for synergistic targeted photothermal and chemodynamic therapy

Yu-Hui Zhang ^{a, c, 1,*,} ,
Ye Tian ^{a, 1} ,
Xianliang Sheng ^{a, *,} ,
Chen-Shuang Liu ^a ,
Lu-Qiang Wei ^a ,
Jie Wang ^a ,
Yong Chen ^{b, *,}

a.
College of Science & College of Material Science and Art Design, Inner Mongolia Agricultural University, Hohhot 010018, China
b.
College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
c.
Inner Mongolia Key Laboratory of Soil Quality and Nutrient Resource & Key Laboratory of Agricultural Ecological Security and Green Development at Universities of Inner Mongolia Autonomous, Hohhot 010018, China

yh_zhangyh@126.com

shengxl@iccas.ac.cn

chenyong@nankai.edu.cn

Received Date: 30 March 2024
Revised Date: 20 June 2024
Accepted Date: 28 June 2024
Available Online: 28 June 2024

Figures(5)

Black phosphorus (BP), as a rising star of 2D nanomaterials has drawn considerable attention in cancer therapy. However, the poor stability under ambient conditions limits their practical applications. Herein, a multiple supramolecular assembly composed of adamantane-modified hyaluronic acid (HAADA), ferrocene-modified cinnamaldehyde (Fc-CA), guanidinium-functionalized β-cyclodextrin (Guano-CD), and black phosphorus (BP) nanosheets was successfully fabricated through cooperative host-guest and electrostatic interactions. Owing to the cooperative contribution of these building blocks, the obtained supramolecular assembly simultaneously possesses multiple functions including excellent stability, good biocompatibility and targeting property, and a high inhibition effect toward cancer cells. We believe that this work might provide new insights into designing a new generation of cancer theranostic protocols for potential clinical applications.
- Black phosphorus,
- Host-guest interaction,
- Cyclodextrin,
- Polysaccharide supramolecular assembly
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