Citation: Yu-Hui Zhang, Ye Tian, Xianliang Sheng, Chen-Shuang Liu, Lu-Qiang Wei, Jie Wang, Yong Chen. Construction of a black phosphorous-based noncovalent multiple nanosupramolecular assembly for synergistic targeted photothermal and chemodynamic therapy[J]. Chinese Chemical Letters, ;2025, 36(4): 110193. doi: 10.1016/j.cclet.2024.110193 shu

Construction of a black phosphorous-based noncovalent multiple nanosupramolecular assembly for synergistic targeted photothermal and chemodynamic therapy

Yu-Hui Zhang ^{a, c, 1,*,} ,
Ye Tian ^{a, 1} ,
Xianliang Sheng ^{a, *,} ,
Chen-Shuang Liu ^a ,
Lu-Qiang Wei ^a ,
Jie Wang ^a ,
Yong Chen ^{b, *,}

a.
College of Science & College of Material Science and Art Design, Inner Mongolia Agricultural University, Hohhot 010018, China
b.
College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
c.
Inner Mongolia Key Laboratory of Soil Quality and Nutrient Resource & Key Laboratory of Agricultural Ecological Security and Green Development at Universities of Inner Mongolia Autonomous, Hohhot 010018, China

yh_zhangyh@126.com

shengxl@iccas.ac.cn

chenyong@nankai.edu.cn

Received Date: 30 March 2024
Revised Date: 20 June 2024
Accepted Date: 28 June 2024
Available Online: 28 June 2024

Figures(5)

Black phosphorus (BP), as a rising star of 2D nanomaterials has drawn considerable attention in cancer therapy. However, the poor stability under ambient conditions limits their practical applications. Herein, a multiple supramolecular assembly composed of adamantane-modified hyaluronic acid (HAADA), ferrocene-modified cinnamaldehyde (Fc-CA), guanidinium-functionalized β-cyclodextrin (Guano-CD), and black phosphorus (BP) nanosheets was successfully fabricated through cooperative host-guest and electrostatic interactions. Owing to the cooperative contribution of these building blocks, the obtained supramolecular assembly simultaneously possesses multiple functions including excellent stability, good biocompatibility and targeting property, and a high inhibition effect toward cancer cells. We believe that this work might provide new insights into designing a new generation of cancer theranostic protocols for potential clinical applications.
- Black phosphorus,
- Host-guest interaction,
- Cyclodextrin,
- Polysaccharide supramolecular assembly
1. [1]
  W. Zhou, T. Pan, H. Cui, et al., Angew. Chem. Int. Ed. 58 (2019) 769–774. doi: 10.1002/anie.201810878
2. [2]
  L. Sutrisno, H. Chen, Y. Chen, et al., Biomaterials 275 (2021) 120923. doi: 10.1016/j.biomaterials.2021.120923
3. [3]
  Z. Li, J. Song, H. Yang, Sci. China Chem. 66 (2023) 406–435. doi: 10.1007/s11426-022-1355-6
4. [4]
  L. Chan, X. Chen, P. Gao, et al., ACS Nano 15 (2021) 3047–3060. doi: 10.1021/acsnano.0c09454
5. [5]
  X. Bai, R. Wang, X. Hu, et al., ACS Nano 18 (2024) 3553–3574. doi: 10.1021/acsnano.3c11177
6. [6]
  J. Huang, B. He, Z. Zhang, et al., Adv. Mater. 32 (2020) 2003382. doi: 10.1002/adma.202003382
7. [7]
  L. Deng, Y. Xu, C. Sun, et al., Sci. Bull. 63 (2018) 917–924. doi: 10.1016/j.scib.2018.05.022
8. [8]
  J. Long, Z. Yao, W. Zhang, et al., Adv. Sci. 10 (2023) 2302539. doi: 10.1002/advs.202302539
9. [9]
  Y. Zhao, L. Tong, Z. Li, et al., Chem. Mater. 29 (2017) 7131–7139. doi: 10.1021/acs.chemmater.7b01106
10. [10]
  Y. Xu, X. Li, Y. Song, et al., ACS Appl. Mater. Interfaces 13 (2021) 50270–50280. doi: 10.1021/acsami.1c16776
11. [11]
  Q. Zhou, Q. Chen, Y. Tong, J. Wang, Angew. Chem. Int. Ed. 55 (2016) 11437–11441. doi: 10.1002/anie.201605168
12. [12]
  G. Liu, H.I. Tsai, X. Zeng, et al., Chem. Eng. J. 375 (2019) 121917. doi: 10.1016/j.cej.2019.121917
13. [13]
  K. Hu, L. Xie, Y. Zhang, et al., Nat. Commun. 11 (2020) 2778. doi: 10.1038/s41467-020-16513-0
14. [14]
  X. Zeng, M. Luo, G. Liu, et al., Adv. Sci. 5 (2018) 1800510. doi: 10.1002/advs.201800510
15. [15]
  W. Liu, A. Dong, B. Wang, H. Zhang, Adv. Sci. 8 (2021) 2003033. doi: 10.1002/advs.202003033
16. [16]
  X. Zhang, Z. Zhang, S. Zhang, et al., Small 13 (2017) 1701210. doi: 10.1002/smll.201701210
17. [17]
  J. Zuo, X. Gao, J. Xiao, Y. Cheng, Chin. Chem. Lett. 34 (2023) 107827. doi: 10.1016/j.cclet.2022.107827
18. [18]
  S. Bai, Y.F. Han, Acc. Chem. Res. 56 (2023) 1213–1227. doi: 10.1021/acs.accounts.3c00102
19. [19]
  C. Liu, H. Bu, X. Duan, H. Li, Y. Bai, ACS Appl. Mater. Interfaces 15 (2023) 38264–38272. doi: 10.1021/acsami.3c06353
20. [20]
  D. Wu, Z. Zhang, X. Li, et al., Biomacromolecules 24 (2023) 1022–1031. doi: 10.1021/acs.biomac.2c01469
21. [21]
  M.X. Wu, H.J. Yan, J. Gao, et al., ACS Appl. Mater. Interfaces 10 (2018) 34655–34663. doi: 10.1021/acsami.8b13758
22. [22]
  M. Zuo, W. Qian, K. Wang, L. Wang, X.Y. Hu, Mater. Chem. Front. 6 (2022) 2790–2795. doi: 10.1039/d2qm00629d
23. [23]
  C. Zhang, J. Niu, J. Li, et al., Chin. Chem. Lett. 35 (2024) 108556. doi: 10.1016/j.cclet.2023.108556
24. [24]
  X. Zhu, J.X. Wang, L.Y. Niu, Q.Z. Yang, Chem. Mater. 31 (2019) 3573–3581. doi: 10.1021/acs.chemmater.9b01338
25. [25]
  T. Xiao, X. Li, L. Zhang, et al., Chin. Chem. Lett. 35 (2024) 108618. doi: 10.1016/j.cclet.2023.108618
26. [26]
  G. Li, Z. Zhuo, B. Wang, et al., J. Am. Chem. Soc. 143 (2021) 10920–10929. doi: 10.1021/jacs.1c01161
27. [27]
  J. Yang, C. Fang, H. Liu, et al., Nanoscale 13 (2021) 15085–15099. doi: 10.1039/d1nr02791c
28. [28]
  J. He, G. Chen, P. Zhao, C. Ou, Nano Res. 14 (2021) 3988–3998. doi: 10.1007/s12274-021-3325-z
29. [29]
  H. Wang, Y. Li, H. Yu, et al., J. Am. Chem. Soc. 141 (2019) 13187–13195. doi: 10.1021/jacs.9b05682
30. [30]
  Z. Xu, S. Jia, W. Wang, et al., Nat. Chem. 11 (2019) 86–93. doi: 10.1038/s41557-018-0164-y
31. [31]
  L. Peng, S. Liu, A. Feng, J. Yuan, Mol. Pharmaceutics 14 (2017) 2475–2486. doi: 10.1021/acs.molpharmaceut.7b00160
32. [32]
  Y. Wang, B. Ma, A.A. Abdeen, et al., ACS Appl. Mater. Interfaces 10 (2018) 31915–31927. doi: 10.1021/acsami.8b09642
33. [33]
  Y. Wang, Z. Pei, W. Feng, Y. Pei, J. Mater. Chem. B 7 (2019) 7656–7675. doi: 10.1039/c9tb01913h
34. [34]
  Y. Bai, C.P. Liu, F.Y. Xie, et al., Carbohyd. Polym. 213 (2019) 411–418.
35. [35]
  H. Wang, P. Liang, L. Zhang, et al., Chin. Chem. Lett. 34 (2023) 108129.
36. [36]
  T. Ji, S. Li, Y. Zhang, et al., ACS Appl. Mater. Interfaces 8 (2016) 3438–3445. doi: 10.1021/acsami.5b11619
37. [37]
  Y.M. Zhang, N.Y. Zhang, K. Xiao, Q. Yu, Y. Liu, Angew. Chem. Int. Ed. 57 (2018) 8649–8653. doi: 10.1002/anie.201804620
38. [38]
  W. Zhang, Z. Zheng, L. Lin, et al., Adv. Sci. 10 (2023) 2304062.
39. [39]
  W. Zhang, L. Lin, J. Guo, et al., Research 2022 (2022) 9814638.
40. [40]
  Y.H. Zhang, C.S. Liu, Y. Tian, et al., Int. J. Biol. Macromol. 242 (2023) 125194.
41. [41]
  J. Tian, B. Huang, Z. Cui, et al., Acta Biomater. 130 (2021) 447–459.
42. [42]
  H. Yang, Z. Duan, F. Liu, Z. Zhao, S. Liu, ACS Macro Lett. 12 (2023) 295–301. doi: 10.1021/acsmacrolett.2c00763
43. [43]
  W. Zhang, P. Xiao, L. Lin, et al., Chin. Chem. Lett. 33 (2022) 4043–4047.
44. [44]
  Y. Ding, C. Wang, Y. Ma, et al., Acta Biomater. 143 (2022) 381–391.
45. [45]
  B.Y. Liu, X.L. Yang, X. Xing, et al., ACS Macro Lett. 8 (2019) 719–723. doi: 10.1021/acsmacrolett.9b00121
46. [46]
  Z. Li, Y.M. Zhang, H.Y. Wang, H. Li, Y. Liu, Macromolecules 50 (2017) 1141–1146. doi: 10.1021/acs.macromol.6b02459
47. [47]
  X. Xu, Z. Zeng, J. Chen, et al., Chem. Eng. J. 390 (2020) 124628.
48. [48]
  Y. Zhang, L. Wang, J. Wang, S. Xin, X. Sheng, Chin. Chem. Lett. 32 (2021) 1902–1906.
49. [49]
  K. Yang, G. Yu, Z. Yang, et al., Angew. Chem. Int. Ed. 60 (2021) 17570–17578. doi: 10.1002/anie.202103721
50. [50]
  X. Hou, D. Zhong, H. Chen, et al., Carbohyd. Polym. 292 (2022) 119662.
51. [51]
  J. Shinn, S. Park, S. Lee, et al., ACS Nano 18 (2024) 4704–4716. doi: 10.1021/acsnano.3c06107
1. [1]
  Jie Yang , Xin-Yue Lou , Dihua Dai , Jingwei Shi , Ying-Wei Yang . Desymmetrized pillar[8]arenes: High-yield synthesis, functionalization, and host-guest chemistry. Chinese Chemical Letters, 2025, 36(1): 109818-. doi: 10.1016/j.cclet.2024.109818
2. [2]
  Xiangjun Zhang , Xiaodi Yang , Yan Wang , Zhongping Xu , Sisi Yi , Tao Guo , Yue Liao , Xiyu Tang , Jianxiang Zhang , Ruibing Wang . A supramolecular nanoprodrug for prevention of gallstone formation. Chinese Chemical Letters, 2025, 36(2): 109854-. doi: 10.1016/j.cclet.2024.109854
3. [3]
  Lijun Mao , Shuo Li , Xin Zhang , Zhan-Ting Li , Da Ma . Cucurbit[n]uril-based nanostructure construction and modification. Chinese Chemical Letters, 2024, 35(8): 109363-. doi: 10.1016/j.cclet.2023.109363
4. [4]
  Shuo Li , Qianfa Liu , Lijun Mao , Xin Zhang , Chunju Li , Da Ma . Benzothiadiazole-based water-soluble macrocycle: Synthesis, aggregation-induced emission and selective detection of spermine. Chinese Chemical Letters, 2024, 35(11): 109791-. doi: 10.1016/j.cclet.2024.109791
5. [5]
  Cheng He , Renlan Huang , Lingling Wei , Qiuhui He , Jinbo Liu , Jiao Chen , Ge Gao , Cheng Yang , Wanhua Wu . Uncovering the mask of sensitizers to switch on the TTA-UC emission by supramolecular host-guest complexation. Chinese Chemical Letters, 2025, 36(4): 110103-. doi: 10.1016/j.cclet.2024.110103
6. [6]
  Siwei Wang , Wei-Lei Zhou , Yong Chen . Cucurbituril and cyclodextrin co-confinement-based multilevel assembly for single-molecule phosphorescence resonance energy transfer behavior. Chinese Chemical Letters, 2024, 35(12): 110261-. doi: 10.1016/j.cclet.2024.110261
7. [7]
  Bingbing Shi , Yuchun Wang , Yi Zhou , Xing-Xing Zhao , Yizhou Li , Nuoqian Yan , Wen-Juan Qu , Qi Lin , Tai-Bao Wei . A supramolecular oligo[2]rotaxane constructed by orthogonal platinum(Ⅱ) metallacycle and pillar[5]arene-based host–guest interactions. Chinese Chemical Letters, 2024, 35(10): 109540-. doi: 10.1016/j.cclet.2024.109540
8. [8]
  Jianmei Guo , Yupeng Zhao , Lei Ma , Yongtao Wang . Ultra-long room temperature phosphorescence, intrinsic mechanisms and application based on host-guest doping systems. Chinese Journal of Structural Chemistry, 2024, 43(9): 100335-100335. doi: 10.1016/j.cjsc.2024.100335
9. [9]
  Jie Zhou , Chuanxiang Zhang , Changchun Hu , Shuo Li , Yuan Liu , Zhu Chen , Song Li , Hui Chen , Rokayya Sami , Yan Deng . Electrochemical aptasensor based on black phosphorus-porous graphene nanocomposites for high-performance detection of Hg²⁺. Chinese Chemical Letters, 2024, 35(11): 109561-. doi: 10.1016/j.cclet.2024.109561
10. [10]
  Yuhao Ma , Yufei Zhou , Mingchuan Yu , Cheng Fang , Shaoxia Yang , Junfeng Niu . Covalently bonded ternary photocatalyst comprising MoSe₂/black phosphorus nanosheet/graphitic carbon nitride for efficient moxifloxacin degradation. Chinese Chemical Letters, 2024, 35(9): 109453-. doi: 10.1016/j.cclet.2023.109453
11. [11]
  Qinwei Lu , Jinjie Lu , Juying Lei , Xubiao Luo , Yanbo Zhou . Cyclodextrin-boosted photocatalytic oxidation for efficient bisphenol A removal. Chinese Chemical Letters, 2025, 36(3): 110017-. doi: 10.1016/j.cclet.2024.110017
12. [12]
  Cheng Wang , Ji Wang , Dong Liu , Zhi-Ling Zhang . Advances in virus-host interaction research based on microfluidic platforms. Chinese Chemical Letters, 2024, 35(12): 110302-. doi: 10.1016/j.cclet.2024.110302
13. [13]
  Zhibin Ren , Shan Li , Xiaoying Liu , Guanghao Lv , Lei Chen , Jingli Wang , Xingyi Li , Jiaqing Wang . Penetrating efficiency of supramolecular hydrogel eye drops: Electrostatic interaction surpasses ligand-receptor interaction. Chinese Chemical Letters, 2024, 35(11): 109629-. doi: 10.1016/j.cclet.2024.109629
14. [14]
  Wenlong Li , Feishi Shan , Qingdong Bao , Qinghua Li , Hua Gao , Leyong Wang . Supramolecular assembly nanoparticle for trans-epithelial treatment of keratoconus. Chinese Chemical Letters, 2024, 35(10): 110060-. doi: 10.1016/j.cclet.2024.110060
15. [15]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
16. [16]
  Xueru Zhao , Aopu Wang , Shimin Wang , Zhijie Song , Li Ma , Li Shao . Adsorption and visual detection of nitro explosives by pillar[n]arenes-based host–guest interactions. Chinese Chemical Letters, 2025, 36(4): 110205-. doi: 10.1016/j.cclet.2024.110205
17. [17]
  Zhenzhu Wang , Chenglong Liu , Yunpeng Ge , Wencan Li , Chenyang Zhang , Bing Yang , Shizhong Mao , Zeyuan Dong . Differentiated self-assembly through orthogonal noncovalent interactions towards the synthesis of two-dimensional woven supramolecular polymers. Chinese Chemical Letters, 2024, 35(5): 109127-. doi: 10.1016/j.cclet.2023.109127
18. [18]
  Xingwen Cheng , Haoran Ren , Jiangshan Luo . Boosting the self-trapped exciton emission in vacancy-ordered double perovskites via supramolecular assembly. Chinese Journal of Structural Chemistry, 2024, 43(6): 100306-100306. doi: 10.1016/j.cjsc.2024.100306
19. [19]
  Zhu Shu , Xin Lei , Yeye Ai , Ke Shao , Jianliang Shen , Zhegang Huang , Yongguang Li . ATP-induced supramolecular assembly based on chromophoric organic molecules and metal complexes. Chinese Chemical Letters, 2024, 35(11): 109585-. doi: 10.1016/j.cclet.2024.109585
20. [20]
  Qian Ren , Xue Dai , Ran Cen , Yang Luo , Mingyang Li , Ziyun Zhang , Qinghong Bai , Zhu Tao , Xin Xiao . A cucurbit[8]uril-based supramolecular phosphorescent assembly: Cell imaging and sensing of amino acids in aqueous solution. Chinese Chemical Letters, 2024, 35(12): 110022-. doi: 10.1016/j.cclet.2024.110022

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(73)
HTML views(4)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142