Citation: Ning Zhang, Mengjie Qin, Jiawen Zhu, Xuejing Lou, Xiao Tian, Wende Ma, Youmei Wang, Minghua Lu, Zongwei Cai. Thickness-controllable synthesis of metal-organic framework based hollow nanoflowers with magnetic core via liquid phase epitaxy for phosphopeptides enrichment[J]. Chinese Chemical Letters, ;2025, 36(4): 110177. doi: 10.1016/j.cclet.2024.110177 shu

Thickness-controllable synthesis of metal-organic framework based hollow nanoflowers with magnetic core via liquid phase epitaxy for phosphopeptides enrichment

Ning Zhang ^{a, *,} ,
Mengjie Qin ^a ,
Jiawen Zhu ^a ,
Xuejing Lou ^a ,
Xiao Tian ^a ,
Wende Ma ^c ,
Youmei Wang ^a ,
Minghua Lu ^{a, *,} ,
Zongwei Cai ^{b, *,}

a.
College of Chemistry and Molecular Sciences, Henan University, Kaifeng 475004, China
b.
State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China
c.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China

zn@henu.edu.cn

mhlu@henu.edu.cn

zwcai@hkbu.edu.hk

Received Date: 28 January 2024
Revised Date: 9 June 2024
Accepted Date: 25 June 2024
Available Online: 25 June 2024

Figures(5)

A thickness-controllable method for preparing metal-organic framework hollow nanoflowers on magnetic cores (Fe₃O₄@MOFs HFs) was demonstrated for the first time. The petal of magnetic core with hollow nanoflower structure served as medium for assembling UiO-66-NH₂ shell with different thickness. To further improve its performance, Zr⁴⁺ was immobilized on the surface of Fe₃O₄@UiO-66-NH₂. Compared with conventional Fe₃O₄@UiO-66-NH₂-Zr⁴⁺ nanospheres, the Fe₃O₄@UiO-66-NH₂-Zr⁴⁺ HFs showed increased enrichment performance for phosphopeptides. The Fe₃O₄@UiO-66-NH₂-Zr⁴⁺ HFs served as an attractive restricted-access adsorption material exhibited good selectivity (m_β-casein:m_BSA=1:1000), high sensitivity (1.0 fmol) and excellent size-exclusion effect (m_{β-casein digests}:m_BSA=1:200). Furthermore, the Fe₃O₄@UiO-66-NH₂-Zr⁴⁺ HFs was successfully applied to the specific capture of ultratrace phosphopeptide from complex biological samples, revealing the great potential for the identification and analysis of trace phosphopeptides in clinical analysis. This work can be easily extended to the fabrication of diverse mag-MOF HFs with multifunctional and easy to post-modify properties, and open up a new avenue for the design and construction of new MOFs material.
- Metal-organic framework,
- Nanoflower,
- Phosphopeptide,
- Serum,
- Saliva
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