Citation: Wenping Dong, Mo Ma, Jingkang Li, Lanlan Xu, Dejiang Gao, Pinyi Ma, Daqian Song. Near-infrared fluorescent probe with large Stokes shift and long emission wavelength for rapid diagnosis of lung cancer via aerosol inhalation delivery[J]. Chinese Chemical Letters, ;2025, 36(5): 110147. doi: 10.1016/j.cclet.2024.110147 shu

Near-infrared fluorescent probe with large Stokes shift and long emission wavelength for rapid diagnosis of lung cancer via aerosol inhalation delivery

Wenping Dong ^a ,
Mo Ma ^{a, b} ,
Jingkang Li ^a ,
Lanlan Xu ^a ,
Dejiang Gao ^a ,
Pinyi Ma ^{a, *,} ,
Daqian Song ^{a, *,}

a.
College of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Changchun 130012, China
b.
School of Pharmacy, Jilin University, Changchun 130012, China

mapinyi@jlu.edu.cn

songdq@jlu.edu.cn

Received Date: 23 April 2024
Revised Date: 19 June 2024
Accepted Date: 20 June 2024
Available Online: 21 June 2024

Figures(4)

The aggressive nature and high mortality rate of lung cancer underscore the imperative need for early diagnosis of the disease. Thus, aminopeptidase N (APN), a potential biomarker for lung cancer, should be thoroughly investigated in this context. This report describes the development of HA-apn, a novel near-infrared fluorescent probe, specifically engineered for the sensitive detection of endogenous APN. Characterized by its high selectivity, straightforward molecular architecture, and suitable optical properties, including a long-wavelength emission at 835 nm and a large Stokes shift of 285 nm, HA-apn had high efficacy in identifying overexpressed APN in tumor cells, which shows its potential in pinpointing malignancies. To further validate its applicability and effectiveness in facilitating the direct and enhanced visualization of pulmonary alterations, an in situ lung cancer mouse model was employed. Notably, HA-apn was applied for in vivo imaging of APN activity in the lung cancer mouse model receiving the probe through aerosol inhalation, and rapid and precise diagnostic results were achieved within 30 min post-administration. Overall, HA-apn can be applied as an effective, non-intrusive tool for the rapid and accurate detection of pulmonary conditions.
- Near-infrared,
- Fluorescent probe,
- Large Stokes shift,
- In situ lung cancer,
- Rapid diagnosis
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沈阳化工大学材料科学与工程学院沈阳 110142