Citation: Yang Liu, Minglu Li, Jianxun Ding, Xuesi Chen. Glycoengineering-assistant biomineralization for tumor blockade therapy[J]. Chinese Chemical Letters, ;2025, 36(5): 110146. doi: 10.1016/j.cclet.2024.110146 shu

Glycoengineering-assistant biomineralization for tumor blockade therapy

Yang Liu ^{a, b} ,
Minglu Li ^{a, *,} ,
Jianxun Ding ^{a, b, c, *,} ,
Xuesi Chen ^{a, b, c}

a.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
c.
Jilin Biomedical Polymers Engineering Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

mlli123@ciac.ac.cn

jxding@ciac.ac.cn

Received Date: 10 May 2024
Revised Date: 18 June 2024
Accepted Date: 20 June 2024
Available Online: 21 June 2024

Figures(6)

Tumor blockade therapy inhibits tumor progression by cutting off essential supplies of nutrients, oxygen, and biomolecules from the surrounding microenvironments. Inspired by natural processes, tumor biomineralization has evolved due to its biocompatibility, self-reinforcing capability, and penetration-independent mechanism. However, the selective induction of tumor biomineralization using synthetic tools presents a significant challenge. Herein, a metabolic glycoengineering-assistant tumor biomineralization strategy was developed. Specifically, the azido group (N₃) was introduced onto the cytomembrane by incubating tumor cells with glycose analog Ac₄ManNAz. In addition, a bisphosphonate-containing polymer, dibenzocyclooctyne-poly(ethylene glycol)-alendronate (DBCO-PEG-ALN, DBPA) was synthesized, which attached to the tumor cell surface via "click chemistry" reaction between DBCO and N₃. Subsequently, the bisphosphonate group on the cell surface chelated with positively charged ions in the microenvironments, triggering a consecutive process of biomineralization. This physical barrier significantly reduced tumor cell viability and mobility in a calcium ion concentration-dependent manner, suggesting its potential as an effective anti-tumor strategy for in vivo applications.
- Metabolic glycoengineering,
- Click chemistry,
- Bioorthogonal reaction,
- Biomineralization,
- Tumor blockade therapy
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