Citation: Mengjie Gao, Zhiqiang Cui, Yue Shen, Yikun Li, Dongxiang Zhang, Xiaoyan Gao, Yaguang Sun, Xin-Dong Jiang, Jianjun Du, Xiaohong Sun. NIR-II emissive aza-BODIPY-based nanoparticles for triggering glioblastoma apoptosis in brain[J]. Chinese Chemical Letters, ;2025, 36(5): 110098. doi: 10.1016/j.cclet.2024.110098 shu

NIR-II emissive aza-BODIPY-based nanoparticles for triggering glioblastoma apoptosis in brain

Mengjie Gao ^{a, 1} ,
Zhiqiang Cui ^{b, d, 1} ,
Yue Shen ^a ,
Yikun Li ^c ,
Dongxiang Zhang ^a ,
Xiaoyan Gao ^{b, e} ,
Yaguang Sun ^f ,
Xin-Dong Jiang ^{a, *,} ,
Jianjun Du ^{c, *,} ,
Xiaohong Sun ^{b, e, *,}

a.
Liaoning & Shenyang Key Laboratory of Functional Dye and Pigment, Shenyang University of Chemical Technology, Shenyang 110142, China
b.
Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China
c.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
d.
Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110032, China
e.
Science Experiment Center, China Medical University, Shenyang 110032, China
f.
Key Laboratory of Inorganic Molecule-Based Chemistry of Liaoning Province, Shenyang University of Chemical Technology, Shenyang 110142, China

xdjiang@syuct.edu.cn

dujj@dlut.edu.cn

xhsun@cmu.edu.cn

Received Date: 7 April 2024
Revised Date: 3 June 2024
Accepted Date: 5 June 2024
Available Online: 6 June 2024

Figures(6)

D-D'-A type aza-borondipyrromethenes (aza-BODIPYs) were prepared by Suzuki cross-coupling reaction. Photothermal conversion efficiency of self-assemble aza-BODIPY-based nanoparticles (DA-azaBDP-NPs) with NIR-II emission (λ_em = 1065 nm) was 37.2% under near infrared (NIR) irradiation, and the outstanding cytotoxicity was triggered by coexistence of DA-azaBDP-NPs and the NIR irradiation, with the decrease of glioblastoma migration and the inhibition of glioblastoma proliferation. DA-azaBDP-NPs could promote glioblastoma autophagy and accelerate the process of cell death. The photothermal therapy (PTT) of DA-azaBDP-NPs can effectively induce glioblastoma death by apoptosis under the NIR irradiation, which is highly promising to be applied in vivo experiments of brain.
- Glioblastoma,
- NIR-II,
- aza-BODIPY,
- PTT,
- Apoptosis
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