Citation: Cheng-Shuang Wang, Bing-Yu Zhou, Yi-Feng Wang, Cheng Yuan, Bo-Han Kou, Wei-Wei Zhao, Jing-Juan Xu. Bifunctional iron-porphyrin metal-organic frameworks for organic photoelectrochemical transistor gating and biosensing[J]. Chinese Chemical Letters, ;2025, 36(3): 110080. doi: 10.1016/j.cclet.2024.110080 shu

Bifunctional iron-porphyrin metal-organic frameworks for organic photoelectrochemical transistor gating and biosensing

Cheng-Shuang Wang ^{a, b} ,
Bing-Yu Zhou ^a ,
Yi-Feng Wang ^a ,
Cheng Yuan ^a ,
Bo-Han Kou ^a ,
Wei-Wei Zhao ^{a, *,} ,
Jing-Juan Xu ^{a, *,}

a.
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
b.
School of Materials Science and Engineering, Yancheng Institute of Technology, Yancheng 224051, China

Received Date: 26 January 2024
Revised Date: 17 April 2024
Accepted Date: 2 June 2024
Available Online: 3 June 2024

Figures(5)

Iron-porphyrin metal-organic frameworks (MOFs) have emerged as a remarkable class of semiconductors with adjustable photoelectrical properties and peroxidase-mimicking activities, yet their full potential remains largely unexplored. The organic photoelectrochemical transistor (OPECT) has been proven to be a prominent platform for diverse applications. Herein, iron-porphyrin MOFs, as bifunctional photo-gating module and horseradish peroxidase-mimicking nanozyme, is explored for novel OPECT bioanalysis. Exemplified by alpha-fetoprotein (AFP)-dependent sandwich immunorecognition and therein glucose oxidase (GOx)-generated H₂O₂ to etch CdS quantum dots on the surface of iron-porphyrin MOFs, this OPECT bioanalysis achieved high-performance AFP detection with a low detection limit of 24 fg/mL. This work featured a bifunctional iron-porphyrin MOFs gated OPECT, which is envisioned to inspire more interest in developing the diverse MOFs-nanozymes toward novel optoelectronics and beyond.
- Organic photoelectrochemical transistor,
- Iron-porphyrin metal-organic frameworks,
- Nanozymes,
- Peroxidase-mimicking activity,
- Biosensing
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