Citation: Hongyi Li, Huiyun Wen, He Zhang, Jin Li, Xiang Cao, Jiaqing Zhang, Yutao Zheng, Saipeng Huang, Weiming Xue, Xiaojun Cai. Polymeric micelle-hydrogel composites design for biomedical applications[J]. Chinese Chemical Letters, ;2025, 36(5): 110072. doi: 10.1016/j.cclet.2024.110072 shu

Polymeric micelle-hydrogel composites design for biomedical applications

Hongyi Li ^{a, b} ,
Huiyun Wen ^{a, *,} ,
He Zhang ^a ,
Jin Li ^a ,
Xiang Cao ^a ,
Jiaqing Zhang ^a ,
Yutao Zheng ^a ,
Saipeng Huang ^a ,
Weiming Xue ^a ,
Xiaojun Cai ^{b, *,}

a.
Department of Chemical Engineering, Northwest University, Xi’an 710069, China
b.
School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China

huiyunwen@nwu.edu.cn

cxj520118@wmu.edu.cn

Received Date: 16 April 2024
Revised Date: 26 May 2024
Accepted Date: 30 May 2024
Available Online: 31 May 2024

Figures(7)

Designing advanced hydrogels with controlled mechanical properties, drug delivery manner and multifunctional properties will be beneficial for biomedical applications. However, the further development of hydrogel is limited due to its poor mechanical property and structural diversity. Hydrogels combined with polymeric micelles to obtain micelle-hydrogel composites have been designed for synergistic enhancement of each original properties. Incorporation polymeric micelles into hydrogel networks can not only enhance the mechanical property of hydrogel, but also expand the functionality of hydrogel. Recent advances in polymeric micelle-hydrogel composites are herein reviewed with a focus on three typical micelle incorporation methods. In this review, we will also highlight some emerging biomedical applications in developing micelle-hydrogel composite with multiple functionalities. In addition, further development and application prospects of the micelle-hydrogels composites have also been addressed.
- Polymeric micelle,
- Hydrogel composites,
- Incorporation methods,
- Biomedical applications,
- Local tumor treatment,
- Tissue engineering
1. [1]
  Y.Y. Cui, W. Zhang, J. Shan, et al., Adv. Healthc. Mater. 13 (2024) e2302566. doi: 10.1002/adhm.202302566
2. [2]
  Z.J. Xu, S.Y. Han, Z.P. Gu, J. Wu, Adv. Healthc. Mater. 9 (2020) e1901502. doi: 10.1002/adhm.201901502
3. [3]
  S. Correa, A.K. Grosskopf, H.L. Hernandez, et al., Chem. Rev. 121 (2021) 11385-11457. doi: 10.1021/acs.chemrev.0c01177
4. [4]
  X.X. Lin, X.L. Wang, L.P. Zeng, et al., Chem. Mater. 33 (2021) 7633-7656. doi: 10.1021/acs.chemmater.1c01019
5. [5]
  M.M. Hao, Z.W. Zhang, Z.Y. Jiao, et al., Chin. Chem. Lett. 34 (2023) 107574. doi: 10.1016/j.cclet.2022.05.088
6. [6]
  H.B. Zhao, M. Liu, Y. Zhang, J.B. Yin, R.J. Pei, Nanoscale 12 (2020) 14976-14995. doi: 10.1039/d0nr03785k
7. [7]
  N.S. Sulaiman, N. Hamzah, S.F. Zakaria, et al., Nanomedicine 16 (2021) 81-84. doi: 10.2217/nnm-2020-0420
8. [8]
  T. Chen, K. Hou, Q. Ren, et al., Macromol. Rapid Commun. 39 (2018) e1800337. doi: 10.1002/marc.201800337
9. [9]
  P.D. Godfrin, H. Lee, J.H. Lee, P.S. Doyle, Small 15 (2019) e1803372. doi: 10.1002/smll.201803372
10. [10]
  F. Karchoubi, R.A. Ghotli, H. Pahlevani, M.B. Salehi, Adv. Ind. Eng. Polym. Res. 7 (2024) 54-78.
11. [11]
  S.H. Lin, A.P.H. Huang, S.H. Hsu, Adv. Funct. Mater. 33 (2023) 2303853. doi: 10.1002/adfm.202303853
12. [12]
  D. Hwang, J.D. Ramsey, A.V. Kabanov, Adv. Drug Deliv. Rev. 156 (2020) 80-118. doi: 10.1016/j.addr.2020.09.009
13. [13]
  B. Ghosh, S. Biswas, J. Control. Release 332 (2021) 127-147. doi: 10.1016/j.jconrel.2021.02.016
14. [14]
  X.Y. Qin, L.M. He, C. L. Feng, et al., ACS Appl. Mater. Interfaces 13 (2021) 46270-46281. doi: 10.1021/acsami.1c11563
15. [15]
  G.J. Chen, Y.Y. Wang, R.S. Xie, S.Q. Gong, Adv. Drug Deliv. Rev. 130 (2018) 58-72. doi: 10.1016/j.addr.2018.07.008
16. [16]
  Y.N. Sun, G.R. Gao, G.L. Du, Y.J. Cheng, J. Fu, ACS Macro Lett. 3 (2014) 496-500. doi: 10.1021/mz500221j
17. [17]
  L. Wei, C.H. Cai, J.P. Lin, T. Chen, Biomaterials 30 (2009) 2606-2613. doi: 10.1016/j.biomaterials.2009.01.006
18. [18]
  L.R. Jiang, W.P. Li, Q.S. Miao, et al., ACS Appl. Polym. Mater. 5 (2023) 8495-8505. doi: 10.1021/acsapm.3c01603
19. [19]
  X.X. Li, X.C. Li, J.L. Yang, et al., Research 6 (2023) 0131. doi: 10.34133/research.0131
20. [20]
  E.A. Appel, M.W. Tibbitt, M.J. Webber, et al., Nat. Commun. 6 (2015) 6295. doi: 10.1038/ncomms7295
21. [21]
  X.H. Zhao, X.Y. Chen, H. Yuk, et al., Chem. Rev. 121 (2021) 4309-4372. doi: 10.1021/acs.chemrev.0c01088
22. [22]
  Z.T. Bao, C.H. Xian, Q.J. Yuan, G.T. Liu, J. Wu, Adv. Healthc. Mater. 8 (2019) e1900670. doi: 10.1002/adhm.201900670
23. [23]
  P. Thoniyot, M.J. Tan, A.A. Karim, D.J. Young, X.J. Loh, Adv. Sci. 2 (2015) 1400010. doi: 10.1002/advs.201400010
24. [24]
  J.Q. Zhu, H. Wu, Z.L. Li, et al., Adv. Mater. 34 (2022) e2201651. doi: 10.1002/adma.202201651
25. [25]
  N. Zeng, L.R. Jiang, Q.S. Miao, et al., J. Biomed. Eng. 38 (2021) 609-620.
26. [26]
  A. Sivashanmugam, R.A. kumar, M.V. Priya, S.V. Nair, R. Jayakumar, Eur. Polym. J. 72 (2015) 543-565. doi: 10.1016/j.eurpolymj.2015.05.014
27. [27]
  P.Y. Li, R.Y. Liu, H.Z. Lei, et al., Int. J. Biol. Macromol. 259 (2024) 129083. doi: 10.1016/j.ijbiomac.2023.129083
28. [28]
  S.Y. Wang, M.W. Urban, Nat. Rev. Mater. 5 (2020) 562-583. doi: 10.1038/s41578-020-0202-4
29. [29]
  S.H. Shin, Y. Eom, E.S. Lee, et al., Adv. Healthc. Mater. 9 (2020) e2000876. doi: 10.1002/adhm.202000876
30. [30]
  C. Guo, Y. Wu, W.L. Li, et al., ACS Appl. Mater. Interfaces 14 (2022) 30480-30492. doi: 10.1021/acsami.2c02725
31. [31]
  C. Hu, F.J. Zhang, L.Y. Long, et al., J. Control. Release 324 (2020) 204-217. doi: 10.1016/j.jconrel.2020.05.010
32. [32]
  K.C. Song, Y.M. Hao, Y. Liu, et al., Carbohydr. Polym. 300 (2023) 120272. doi: 10.1016/j.carbpol.2022.120272
33. [33]
  Y. Wu, Y. Wang, L. Long, et al., J. Control. Release 341 (2022) 147-165. doi: 10.1016/j.jconrel.2021.11.027
34. [34]
  T. Zhou, H. Xiong, S.Q. Wang, et al., Mater. Today Nano 17 (2022) 100164. doi: 10.1016/j.mtnano.2021.100164
35. [35]
  P. Lavrador, M.R. Esteves, V.M. Gaspar, J.F. Mano, Adv. Funct. Mater. 31 (2021) 2005941. doi: 10.1002/adfm.202005941
36. [36]
  J. Qu, X. Zhao, Y.P. Liang, et al., Biomaterials 183 (2018) 185-199. doi: 10.1016/j.biomaterials.2018.08.044
37. [37]
  H.S. Abandansari, S. Pakian, M.R. Nabid, M. Ebrahimi, A. Rezalotfi, Eur. Polym. J. 157 (2021) 110646. doi: 10.1016/j.eurpolymj.2021.110646
38. [38]
  K. Fang, R. Wang, H. Zhang, et al., ACS Appl. Mater. Interfaces 12 (2020) 52307-52318. doi: 10.1021/acsami.0c13009
39. [39]
  L.L. Fan, Z. Zeng, R.X. Zhu, et al., Chem. Mater. 34 (2022) 6408-6419. doi: 10.1021/acs.chemmater.2c01001
40. [40]
  C.H. Luo, X. Shuai, X.Y. Deng, et al., Eur. Polym. J. 167 (2022) 111047. doi: 10.1016/j.eurpolymj.2022.111047
41. [41]
  E. Russo, C. Villa, Pharmaceutics 11 (2019) 671. doi: 10.3390/pharmaceutics11120671
42. [42]
  H.K. He, M. Sofman, A.J.S. Wang, et al., Biomacromolecules 21 (2020) 566-580. doi: 10.1021/acs.biomac.9b01297
43. [43]
  L. Zhai, Y.J. Shi, Y. Yan, et al., Chin. Chem. Lett. 34 (2023) 108104. doi: 10.1016/j.cclet.2022.108104
44. [44]
  W.W. Wang, J.J. Liu, C. Li, et al., J. Mater. Chem. B 2 (2014) 4185-4192. doi: 10.1039/c4tb00275j
45. [45]
  R. Wang, X. Wang, X. L Mu, et al., Acta Biomater. 148 (2022) 142-151. doi: 10.1016/j.actbio.2022.06.007
46. [46]
  L. Hahn, E. Karakaya, T. Zorn, et al., Biomacromolecules 22 (2021) 3017-3027. doi: 10.1021/acs.biomac.1c00427
47. [47]
  Y. Xiong, T.S. Wang, L. Liu, et al., Chem. Eng. J. 451 (2023) 138889. doi: 10.1016/j.cej.2022.138889
48. [48]
  Z. Shao, W.M. Cheng, X.M. Hu, et al., Polym. Chem. 11 (2020) 2300-2304. doi: 10.1039/c9py01839e
49. [49]
  C. Lang, J.A. Lanasa, N. Utomo, et al., Nat. Commun. 10 (2019) 3855. doi: 10.1038/s41467-019-11804-7
50. [50]
  C.U. Blank, E.A. Rozeman, L.F. Fanchi, et al., Nat. Med. 24 (2018) 1655-1661. doi: 10.1038/s41591-018-0198-0
51. [51]
  A. Marabelle, L. Tselikas, T. Baere, R. Houot, Ann. Oncol. 28 (2017) xii33-xii43. doi: 10.1093/annonc/mdx683
52. [52]
  Y. Liu, M. Zhu, M.S. Meng, et al., Chin. Chem. Lett. 34 (2023) 107583. doi: 10.1016/j.cclet.2022.06.006
53. [53]
  L. Kang, Z.G. Gao, W. Huang, M.J. Jin, Q.M. Wang, Acta Pharm. Sin. B 5 (2015) 169-175. doi: 10.1016/j.apsb.2015.03.001
54. [54]
  C. Zhang, J. Niu, J.Q. Li, et al., Chin. Chem. Lett. 35 (2024) 108556. doi: 10.1016/j.cclet.2023.108556
55. [55]
  J. Woodcock, J.P. Griffin, R.E. Behrman, N. Engl. J. Med. 364 (2011) 985-987. doi: 10.1056/NEJMp1101548
56. [56]
  F.Z. Jouzdani, J.D. Wolf, F. Atyabi, A.B. Schnurch, Expert Opin. Drug Deliv. 15 (2018) 1007-1019. doi: 10.1080/17425247.2018.1517741
57. [57]
  W. Li, J. Tang, D. Lee, et al., Nat. Rev. Mater. 7 (2022) 406-420. doi: 10.1038/s41578-021-00405-w
58. [58]
  T. Kang, G.D. Cha, O.K. Park, et al., ACS Nano 17 (2023) 5435-5447. doi: 10.1021/acsnano.2c10094
59. [59]
  W. Li, C. Tao, J.X. Wang, et al., RSC Adv. 9 (2019) 31264-31273. doi: 10.1039/c9ra04343h
60. [60]
  H.F. Darge, E.Y. Hanurry, Y.S. Birhan, et al, Chem. Eng. J. 406 (2021) 126879. doi: 10.1016/j.cej.2020.126879
61. [61]
  E.K. Gebeyehu, X.F. Sui, B.F. Adamu, et al., Gels 8 (2022) 140. doi: 10.3390/gels8030140
62. [62]
  F. Berthiaume, T.J. Maguire, M.L. Yarmush, Annu. Rev. Chem. Biomol. Eng. 2 (2011) 403-430. doi: 10.1146/annurev-chembioeng-061010-114257
63. [63]
  X.Q. Hao, X. W. Zhang, Y. Hu, et al., Chin. Chem. Lett. 34 (2023) 107965. doi: 10.1016/j.cclet.2022.107965
64. [64]
  P. Zarrintaj, J.D. Ramsey, A. Samadi, et al., Acta Biomater. 110 (2020) 37-67. doi: 10.1016/j.actbio.2020.04.028
65. [65]
  S. Pina, J.M. Oliveira, R.L. Reis, Adv. Mater. 27 (2015) 1143-1169. doi: 10.1002/adma.201403354
66. [66]
  S. Choi, H. Ahn, S.H. Kim, J. Appl. Polym. Sci. 139 (2021) 51887.
67. [67]
  K. Elkhoury, C.S. Russell, L. S. Gonzalez, et al., Adv. Healthc. Mater. 8 (2019) e1900506. doi: 10.1002/adhm.201900506
68. [68]
  Z.R. He, C.H. Sun, Y.F. Ma, et al., Adv. Mater. 36 (2024) e2306552. doi: 10.1002/adma.202306552
69. [69]
  S.F. Yan, J. Ren, Y.H. Jian, et al., Biomacromolecules 19 (2018) 4554-4564. doi: 10.1021/acs.biomac.8b01234
70. [70]
  S. Peressotti, G.E. Koehl, J.A. Goding, R.A. Green, ACS Biomater. Sci. Eng. 7 (2021) 4136-4163. doi: 10.1021/acsbiomaterials.1c00030
71. [71]
  Y. Zhao, S.L. Song, X.Z. Ren, et al., Chem. Rev. 122 (2022) 5604-5640. doi: 10.1021/acs.chemrev.1c00815
72. [72]
  R. Balint, N.J. Cassidy, S.H. Cartmell, Acta Biomater. 10 (2014) 2341-2353. doi: 10.1016/j.actbio.2014.02.015
73. [73]
  N. Alegret, A.D. Alfaro, D. Mecerreyes, Biomacromolecules 20 (2019) 73-89. doi: 10.1021/acs.biomac.8b01382
74. [74]
  V. Pertici, C. Pin-Barre, C. Rivera, et al., Biomacromolecules 20 (2019) 149-163. doi: 10.1021/acs.biomac.8b01242
75. [75]
  P.P. Deng, F.X. Chen, H.D. Zhang, Y. Chen, J.P. Zhou, Adv. Healthc. Mater. 11 (2022) e2200115. doi: 10.1002/adhm.202200115
76. [76]
  M. Rodrigues, N. Kosaric, C.A. Bonham, G.C. Gurtner, Physiol. Rev. 99 (2019) 665-706. doi: 10.1152/physrev.00067.2017
77. [77]
  X. Zhao, H. Wu, B.L. Guo, et al., Biomaterials 122 (2017) 34-47. doi: 10.1016/j.biomaterials.2017.01.011
78. [78]
  C.C. Yates, D. Whaley, R. Bahu, et al., Biomaterials 28 (2007) 3977-3986. doi: 10.1016/j.biomaterials.2007.05.008
79. [79]
  S. Sharifi, M.J. Hajipour, L. Gould, Mol. Pharm. 18 (2021) 550-575. doi: 10.1021/acs.molpharmaceut.0c00346
80. [80]
  G.S. Lazarus, D.M. Cooper, D.R. Kinghton, et al., Arch. Dermatol. 130 (1994) 489-493. doi: 10.1001/archderm.1994.01690040093015
81. [81]
  G.T. Liu, Y. Zhou, Z.J. Xu, et al., Chin. Chem. Lett. 34 (2023) 107705. doi: 10.1016/j.cclet.2022.07.048
82. [82]
  X. Zhang, P. Wei, Z.Y. Yang, et al., Pharmaceutics 15 (2023) 68.
83. [83]
  S. Cascone, G. Lamberti, Int. J. Pharm. 573 (2020) 118803. doi: 10.1016/j.ijpharm.2019.118803
84. [84]
  A. Gupta, M. Kowalczuk, W. Heaselgrave, et al., Eur. Polym. J. 111 (2019) 134-151. doi: 10.1016/j.eurpolymj.2018.12.019
85. [85]
  S.Q. Wang, H. Zheng, L. Zhou, et al., Nano Lett. 20 (2020) 5149-5158. doi: 10.1021/acs.nanolett.0c01371
86. [86]
  B. Yang, J.L. Song, Y.H. Jiang, et al., ACS Appl. Mater. Interfaces 12 (2020) 57782-57797. doi: 10.1021/acsami.0c18948
87. [87]
  A. Sharma, P. Mittal, A. Yadav, et al., ACS Appl. Bio. Mater. 5 (2022) 598-609. doi: 10.1021/acsabm.1c01078
88. [88]
  A. Rungrod, A. Kapanya, W. Punyodom, et al., Biomacromolecules 22 (2021) 3839-3859. doi: 10.1021/acs.biomac.1c00683
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