Citation: Haijiang Gong, Qingtan Zeng, Shili Gai, Yaqian Du, Jing Zhang, Qingyu Wang, He Ding, Lichun Wu, Anees Ahmad Ansari, Piaoping Yang. Enzyme-based colorimetric signal amplification strategy in lateral flow immunoassay[J]. Chinese Chemical Letters, ;2025, 36(5): 110059. doi: 10.1016/j.cclet.2024.110059 shu

Enzyme-based colorimetric signal amplification strategy in lateral flow immunoassay

Haijiang Gong ^{a, 1} ,
Qingtan Zeng ^{b, 1} ,
Shili Gai ^{a, c, *,} ,
Yaqian Du ^a ,
Jing Zhang ^a ,
Qingyu Wang ^a ,
He Ding ^{a, *,} ,
Lichun Wu ^{d, *,} ,
Anees Ahmad Ansari ^e ,
Piaoping Yang ^{a, c, *,}

a.
Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, China
b.
Changhai Hospital Affiliated to Navy Military Medical University, Shanghai 200086, China
c.
Yantai Research Institute, Harbin Engineering University, Yantai 264000, China
d.
Department of Clinical Laboratory, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China
e.
King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia

gaishili@hrbeu.edu.cn

dinghe@hrbeu.edu.cn

wulichun@scszlyy.org.cn

yangpiaoping@hrbeu.edu.cn

Received Date: 22 March 2024
Revised Date: 24 May 2024
Accepted Date: 27 May 2024
Available Online: 1 June 2024

Figures(9)

Lateral flow immunoassay (LFIA), a rapid detection technique noted for simplicity and economy, has showcased indispensable applicability in diverse domains such as disease screening, food safety, and environmental monitoring. Nevertheless, challenges still exist in detecting ultra-low concentration analytes due to the inherent sensitivity limitations of LFIA. Recently, significant advances have been achieved by integrating enzyme activity probes and transforming LFIA into a highly sensitive tool for rapidly detecting trace analyte concentrations. Specifically, modifying natural enzymes or engineered nanozymes allows them to function as immune probes, directly catalyzing the production of signal molecules or indirectly initiating enzyme activity. Therefore, the signal intensity and detection sensitivity of LFIA are markedly elevated. The present review undertakes a comprehensive examination of pertinent research literature, offering a systematic analysis of recently proposed enzyme-based signal amplification strategies. By way of comparative assessment, the merits and demerits of current approaches are delineated, along with the identification of research avenues that still need to be explored. It is anticipated that this critical overview will garner considerable attention within the biomedical and materials science communities, providing valuable direction and insight toward the advancement of high-performance LFIA technologies.
- Lateral flow immunoassay,
- Signal amplification,
- Enzyme-based enhancement,
- Catalysis,
- Colorimetric signal
1. [1]
  S.E. Son, S.H. Cheon, W. Hur, et al., Biosens. Bioelectron. 243 (2024) 115752. doi: 10.1016/j.bios.2023.115752
2. [2]
  P. Tripathi, A. Kumar, M. Sachan, et al., Biosens. Bioelectron. 165 (2020) 112368. doi: 10.1016/j.bios.2020.112368
3. [3]
  H. Chen, X. Ma, X. Zhang, et al., Chin. Chem. Lett. 34 (2023) 107701. doi: 10.1016/j.cclet.2022.07.044
4. [4]
  H. Zhao, E. Su, L. Huang, et al., Chin. Chem. Lett. 33 (2022) 743–746. doi: 10.3390/ijerph20010743
5. [5]
  X. Yin, J. Hou, J. Guo, et al., Chem. Eng. J. 469 (2023) 143979. doi: 10.1016/j.cej.2023.143979
6. [6]
  S. Liu, R. Shu, J. Ma, et al., Chem. Eng. J. 446 (2022) 137382. doi: 10.1016/j.cej.2022.137382
7. [7]
  S. Liu, X. He, T. Zhang, et al., Chin. Chem. Lett. 33 (2022) 1933–1935. doi: 10.1016/j.cclet.2021.11.051
8. [8]
  Y. Liu, T. Li, G. Yang, et al., Chin. Chem. Lett. 33 (2022) 1913–1916. doi: 10.1016/j.cclet.2021.11.025
9. [9]
  W. Li, Z. Wang, X. Wang, et al., J. Environ. Chem. Eng. 11 (2023) 110494. doi: 10.1016/j.jece.2023.110494
10. [10]
  M. Tian, W. Xie, T. Zhang, et al., Sens. Actuators B: Chem. 309 (2020) 127728. doi: 10.1016/j.snb.2020.127728
11. [11]
  M. Song, J. Xing, H. Cai, et al., ACS Nano 17 (2023) 10748–10759. doi: 10.1021/acsnano.3c02164
12. [12]
  N. Yao, X. Li, Y. Tian, et al., Sens. Actuators B: Chem. 379 (2023) 133247. doi: 10.1016/j.snb.2022.133247
13. [13]
  E. Renzi, A. Piper, F. Nastri, et al., Small 19 (2023) 2207949. doi: 10.1002/smll.202207949
14. [14]
  G. Li, Q. Li, X. Wang, et al., Int. J. Biol. Macromol. 242 (2023) 125186. doi: 10.1016/j.ijbiomac.2023.125186
15. [15]
  Y. Liu, L. Zhan, Z. Qin, et al., ACS Nano 15 (2021) 3593–3611. doi: 10.1021/acsnano.0c10035
16. [16]
  J. Liu, M. Li, Q. Man, et al., Anal. Chem. 95 (2023) 8011–8019. doi: 10.1021/acs.analchem.3c00892
17. [17]
  W. Qiao, B. He, J. Yang, et al., Int. J. Biol. Macromol. 254 (2024) 127746. doi: 10.1016/j.ijbiomac.2023.127746
18. [18]
  A.R. Gul, J. Bal, P. Xu, et al., Biosens. Bioelectron. 246 (2024) 115902. doi: 10.1016/j.bios.2023.115902
19. [19]
  C. Lu, W. Xiao, Y. Su, et al., ACS Sens. 8 (2023) 1950–1959. doi: 10.1021/acssensors.2c02706
20. [20]
  X. Ruan, V. Hulubei, Y. Wang, et al., Biosens. Bioelectron. 208 (2022) 114190. doi: 10.1016/j.bios.2022.114190
21. [21]
  J. Xu, L. Dou, S. Liu, et al., Food Chem. 352 (2021) 129415. doi: 10.1016/j.foodchem.2021.129415
22. [22]
  J. Feng, Y. Xue, X. Wang, et al., Sci. Total Environ. 834 (2022) 155354. doi: 10.1016/j.scitotenv.2022.155354
23. [23]
  E.Y. Kwon, X. Ruan, F. Yu, et al., Food Chem. 399 (2023) 133955. doi: 10.1016/j.foodchem.2022.133955
24. [24]
  Y. Chen, L. Fan, W. Deng, et al., J. Infect. 85 (2022) 702–769.
25. [25]
  E.I. Newsham, E.A. Phillips, H. Ma, et al., Lab Chip 22 (2022) 2741–2752. doi: 10.1039/d2lc00297c
26. [26]
  P. Srithong, S. Chaiyo, E. Pasomsub, et al., Microchim. Acta 189 (2022) 386. doi: 10.1007/s00604-022-05467-3
27. [27]
  A.H. Iles, P.J.W. He, I.N. Katis, et al., Talanta 248 (2022) 123579. doi: 10.1016/j.talanta.2022.123579
28. [28]
  X. Cai, F. Ma, J. Jiang, et al., J. Hazard. Mater. 441 (2023) 129853. doi: 10.1016/j.jhazmat.2022.129853
29. [29]
  Y. Chen, J. Ren, X. Yin, et al., Anal. Chem. 94 (2022) 8693–8703. doi: 10.1021/acs.analchem.2c01008
30. [30]
  J. Hu, X. Xu, L. Xu, et al., Food Biosci. 51 (2023) 102353. doi: 10.1016/j.fbio.2023.102353
31. [31]
  J. Liang, Z. Liu, Y. Fang, et al., Food Chem. 417 (2023) 135897. doi: 10.1016/j.foodchem.2023.135897
32. [32]
  L. Zhu, Z. Lu, L. Zhang, et al., Chin. Chem. Lett. 33 (2022) 2491–2495. doi: 10.1016/j.cclet.2021.11.038
33. [33]
  Z. Ren, L. Xu, L. Yang, et al., Anal. Chem. 95 (2023) 6646–6654. doi: 10.1021/acs.analchem.3c00057
34. [34]
  X. Zhang, J. Wang, J. Liang, et al., Food Chem. 390 (2022) 133188. doi: 10.1016/j.foodchem.2022.133188
35. [35]
  S. Tao, X. Zhao, D. Bao, et al., ACS Appl. Mater. Interfaces 15 (2023) 27612–27623. doi: 10.1021/acsami.3c03434
36. [36]
  X. Yang, X. Cheng, H. Wei, et al., J. Nanobiotechnology 21 (2023) 450. doi: 10.1109/psgec58411.2023.10255866
37. [37]
  Z. Xie, S. Feng, F. Pei, et al., Anal. Chim. Acta 1233 (2022) 340486. doi: 10.1016/j.aca.2022.340486
38. [38]
  M. Hussain, X. Liu, J. Zou, et al., Chin. Chem. Lett. 33 (2022) 1885–1888. doi: 10.1016/j.cclet.2021.09.044
39. [39]
  X. Liu, X. Su, M. Chen, et al., Biosens. Bioelectron. 245 (2024) 115840. doi: 10.1016/j.bios.2023.115840
40. [40]
  J. Wang, Y. Zheng, X. Wang, et al., Sci. Total Environ. 912 (2024) 169440. doi: 10.1016/j.scitotenv.2023.169440
41. [41]
  C. Lin, Z. Liu, F. Fang, et al., ACS Sens. 8 (2023) 3733–3743. doi: 10.1021/acssensors.3c01019
42. [42]
  B. Wang, T. Peng, Z. Jiang, et al., ACS Sens. 8 (2023) 4512–4520. doi: 10.1021/acssensors.3c01028
43. [43]
  G. Wang, L. Wang, Z. Meng, et al., Adv. Fiber Mater. 4 (2022) 1304–1333. doi: 10.1007/s42765-022-00179-y
44. [44]
  Z. Guo, B. Jin, Y. Fang, et al., Chin. Chem. Lett. 33 (2022) 4208–4212. doi: 10.1016/j.cclet.2022.01.081
45. [45]
  A. Sena-Torralba, Y.D. Banguera-Ordoñez, L. Mira-Pascual, et al., Trends Biotechnol. 41 (2023) 1299–1313. doi: 10.1016/j.tibtech.2023.04.004
46. [46]
  B. Fang, Q. Xiong, H. Duan, et al., Trends Analyt. Chem. 157 (2022) 116754. doi: 10.1016/j.trac.2022.116754
47. [47]
  J. Wu, X. Wang, Q. Wang, et al., Chem. Soc. Rev. 48 (2019) 1004–1076. doi: 10.1039/c8cs00457a
48. [48]
  C. Parolo, A.d.l. Escosura-Muñiz, A. Merkoçi, Biosens. Bioelectron. 40 (2013) 412–416. doi: 10.1016/j.bios.2012.06.049
49. [49]
  G.B. Aktas, J.H. Wichers, V. Skouridou, et al., Microchimica Acta 186 (2019) 426. doi: 10.1007/s00604-019-3544-0
50. [50]
  V.G. Panferov, I.V. Safenkova, A.V. Zherdev, et al., Talanta 225 (2021) 121961. doi: 10.1016/j.talanta.2020.121961
51. [51]
  F. Chai, D. Wang, L. Zhu, et al., Anal. Chem. 94 (2022) 6628–6634. doi: 10.1021/acs.analchem.2c01177
52. [52]
  Y. Chen, J. Sun, Y. Xianyu, et al., Nanoscale 8 (2016) 15205–15212. doi: 10.1039/C6NR04017A
53. [53]
  Z. Huang, S. Zhou, X. Wang, et al., Sens. Actuators B: Chem. 385 (2023) 133699. doi: 10.1016/j.snb.2023.133699
54. [54]
  H. Wang, C. Yao, J. Fan, et al., Biosens. Bioelectron. 237 (2023) 115508. doi: 10.1016/j.bios.2023.115508
55. [55]
  Y. Chen, K. Tang, Q. Zhou, et al., Anal. Chem. 95 (2023) 18139–18148. doi: 10.1021/acs.analchem.3c03571
56. [56]
  C. Zhou, R. Cheng, B. Liu, et al., Sens. Actuators B: Chem. 402 (2024) 135118. doi: 10.1016/j.snb.2023.135118
57. [57]
  P. Nie, X. Gao, X. Yang, et al., Food Chem. 439 (2024) 138122. doi: 10.1016/j.foodchem.2023.138122
58. [58]
  L. Dou, Y. Bai, M. Liu, et al., Biosens. Bioelectron. 204 (2022) 114093. doi: 10.1016/j.bios.2022.114093
59. [59]
  R. Chen, X. Chen, Y. Zhou, et al., ACS Nano 16 (2022) 3351–3361. doi: 10.1021/acsnano.2c00008
60. [60]
  J. Ren, X. Yin, H. Hu, et al., Sens. Actuators B: Chem. 367 (2022) 132150. doi: 10.1016/j.snb.2022.132150
61. [61]
  T. Bu, F. Bai, X. Sun, et al., Food Chem. 344 (2021) 128711. doi: 10.1016/j.foodchem.2020.128711
62. [62]
  J.H. Fu, Y. Zhou, X. Huang, et al., J. Agric. Food. Chem. 68 (2020) 1118–1125. doi: 10.1021/acs.jafc.9b07076
63. [63]
  S. Li, Y. Zhang, Q. Wang, et al., Anal. Chem. 94 (2021) 312–323.
64. [64]
  F. Arshad, S.N.A. Zakaria, M.U. Ahmed, Food Chem. 438 (2024) 137947. doi: 10.1016/j.foodchem.2023.137947
65. [65]
  J. Li, P. Liang, T. Zhao, et al., Anal. Bioanal. Chem. 415 (2023) 545–554. doi: 10.1007/s00216-022-04437-1
66. [66]
  O.D. Hendrickson, E.A. Zvereva, A.V. Zherdev, et al., Food Control. 133 (2022) 108655. doi: 10.1016/j.foodcont.2021.108655
67. [67]
  R. Zhao, Y. Tang, D. Song, et al., Anal. Chem. 95 (2023) 18522–18529. doi: 10.1021/acs.analchem.3c03900
68. [68]
  J. Xu, M. Wang, M. Li, et al., Anal. Chim. Acta 1279 (2023) 341834. doi: 10.1016/j.aca.2023.341834
69. [69]
  X. Li, C. Qian, Y. Tian, et al., Chem. Eng. J. 457 (2023) 141324. doi: 10.1016/j.cej.2023.141324
70. [70]
  X. Meng, W. Zuo, P. Wu, et al., Nano Lett. 24 (2023) 51–60.
71. [71]
  M. Liang, X. Cai, Y. Gao, et al., Biosens. Bioelectron. 213 (2022) 114435. doi: 10.1016/j.bios.2022.114435
72. [72]
  X. Wang, C. Hong, Z. Lin, et al., Food Sci. Hum. Well. 13 (2024) 879–884. doi: 10.26599/fshw.2022.9250075
73. [73]
  J. Cai, Y. Lin, X. Yu, et al., Sens. Actuators B: Chem. 394 (2023) 134279. doi: 10.1016/j.snb.2023.134279
74. [74]
  X. Zhang, Y. Shi, D. Wu, et al., Food Chem. 434 (2024) 137455. doi: 10.1016/j.foodchem.2023.137455
75. [75]
  J. Ren, L. Su, H. Hu, et al., Food Chem. 377 (2022) 131920. doi: 10.1016/j.foodchem.2021.131920
76. [76]
  D. Hui, Z. Jiangyan, W. Yating, et al., Anal. Chem. 96 (2024) 1789–1794. doi: 10.1021/acs.analchem.3c05140
77. [77]
  Z. Zhang, N. Zhu, Y. Zou, et al., Anal. Chim. Acta 1035 (2018) 168–174. doi: 10.1016/j.aca.2018.06.039
78. [78]
  D. Xu, J. Zhang, Z. Luo, et al., Food Chem. 439 (2024) 138125. doi: 10.1016/j.foodchem.2023.138125
79. [79]
  M.S. Chang, C.Y. Lee, E.S. Liu, et al., Anal. Chem. 95 (2023) 14341–14349. doi: 10.1021/acs.analchem.3c02684
80. [80]
  Y.C. Chen, J.J. Chen, Y.J. Hsiao, et al., Sens. Actuators B: Chem. 336 (2021) 129725. doi: 10.1016/j.snb.2021.129725
81. [81]
  Q. Zhao, D. Lu, G. Zhang, et al., Talanta 223 (2021) 121722. doi: 10.1016/j.talanta.2020.121722
82. [82]
  Nirala, Shtenberg, Biomolecules 9 (2019) 372. doi: 10.3390/biom9080372
83. [83]
  Y. Zhang, X. Liao, G. Yu, et al., Anal. Chem. 95 (2023) 13698–13707. doi: 10.1021/acs.analchem.3c02990
84. [84]
  L.H. Ma, H.B. Wang, T. Zhang, et al., Sens. Actuators B: Chem. 298 (2019) 126819. doi: 10.1016/j.snb.2019.126819
85. [85]
  W. Pengcheng, S. Jiaren, S. Caixia, et al., Trends Analyt. Chem. 166 (2023) 117203. doi: 10.1016/j.trac.2023.117203
86. [86]
  Y. Chang, Q. Zhang, W. Xue, et al., Chem. Commun. 59 (2023) 3399–3402. doi: 10.1039/d3cc00228d
87. [87]
  L. Zhang, X. Bi, X. Liu, et al., Nanoscale 15 (2023) 12853–12867. doi: 10.1039/d3nr02024j
88. [88]
  Q. Wang, J. Jiang, L. Gao, WIREs Nanomed. Nanobi. 14 (2022) e1769. doi: 10.1002/wnan.1769
89. [89]
  J. Chen, X. Liu, G. Zheng, et al., Small 19 (2022) 2205924.
90. [90]
  B. Liu, Z. Sun, P.J.J. Huang, et al., J. Am. Chem. Soc. 137 (2015) 1290–1295. doi: 10.1021/ja511444e
91. [91]
  Z. Yi, X. Yang, Y. Liang, et al., Small 20 (2024) 2305974. doi: 10.1002/smll.202305974
92. [92]
  X. Yu, Y. Wang, J. Zhang, et al., Adv. Healthc. Mater. 13 (2023) 2302023.
93. [93]
  S. Liang, X. Deng, Y. Chang, et al., Nano Lett. 19 (2019) 4134–4145. doi: 10.1021/acs.nanolett.9b01595
94. [94]
  D. Zhu, N. Li, M. Zhang, et al., Biosens. Bioelectron. 243 (2024) 115786. doi: 10.1016/j.bios.2023.115786
95. [95]
  J. Wang, Y. Chu, Z. Zhao, et al., J. Nanobiotechnology 21 (2023) 311. doi: 10.3390/machines11020311
96. [96]
  L. Zhang, L. Xu, Y. Wang, et al., Chin. Chem. Lett. 33 (2022) 4089–4095. doi: 10.1016/j.cclet.2022.01.071
97. [97]
  Y. He, M. Feng, X. Zhang, et al., Anal. Chim. Acta 1283 (2023) 341959. doi: 10.1016/j.aca.2023.341959
98. [98]
  Y. Tang, Y. Han, J. Zhao, et al., Nano-Micro Lett. 15 (2023) 112.
99. [99]
  B. Jiang, D. Duan, L. Gao, et al., Nat. Protoc. 13 (2018) 1506–1520. doi: 10.1038/s41596-018-0001-1
100. [100]
  S. Singh, P. Tripathi, N. Kumar, et al., Biosens. Bioelectron. 92 (2017) 280–286. doi: 10.1016/j.bios.2016.11.011
101. [101]
  Q. Liu, X. Wang, Y. Zhang, et al., Biosens. Bioelectron. 244 (2024) 115785. doi: 10.1016/j.bios.2023.115785
102. [102]
  G. Yim, C.Y. Kim, S. Kang, et al., ACS Appl. Mater. Interfaces 12 (2020) 41062–41070. doi: 10.1021/acsami.0c10981
103. [103]
  M. Zandieh, J. Liu, ACS Nano 15 (2021) 15645–15655. doi: 10.1021/acsnano.1c07520
104. [104]
  Y. Wu, W. Xu, L. Jiao, et al., Mater. Today 52 (2022) 327–347. doi: 10.1016/j.mattod.2021.10.032
105. [105]
  Z. Zeng, X. Wang, T. Yang, et al., Anal. Chim. Acta 1245 (2023) 340861. doi: 10.1016/j.aca.2023.340861
106. [106]
  O.D. Hendrickson, E.A. Zvereva, A.V. Zherdev, et al., Foods 11 (2022) 1691. doi: 10.3390/foods11121691
107. [107]
  W. Peng, Y. Qin, W. Li, et al., ACS Sens. 5 (2020) 1912–1920. doi: 10.1021/acssensors.9b02355
108. [108]
  J. Guo, Y. Li, B. Wang, et al., Microchim. Acta 189 (2022) 468. doi: 10.1007/s00604-022-05538-5
109. [109]
  T. Bai, L. Wang, M. Wang, et al., Biosens. Bioelectron. 208 (2022) 114218. doi: 10.1016/j.bios.2022.114218
1. [1]
  Bo Liu , Shuaiqiang Shao , Junjie Cai , Zijian Zhang , Feng Tian , Kun Yang , Fan Li . Signal cascade amplification of streptavidin-biotin-modified immunofluorescence nanocapsules for ultrasensitive detection of glial fibrillary acidic protein. Chinese Chemical Letters, 2025, 36(3): 109814-. doi: 10.1016/j.cclet.2024.109814
2. [2]
  Fangling Cui , Zongjie Hu , Jiayu Huang , Xiaoju Li , Ruihu Wang . MXene-based materials for separator modification of lithium-sulfur batteries. Chinese Journal of Structural Chemistry, 2024, 43(7): 100337-100337. doi: 10.1016/j.cjsc.2024.100337
3. [3]
  Shuai Li , Liuting Zhang , Fuying Wu , Yiqun Jiang , Xuebin Yu . Efficient catalysis of FeNiCu-based multi-site alloys on magnesium-hydride for solid-state hydrogen storage. Chinese Chemical Letters, 2025, 36(1): 109566-. doi: 10.1016/j.cclet.2024.109566
4. [4]
  Fengxing Liang , Yongzheng Zhu , Nannan Wang , Meiping Zhu , Huibing He , Yanqiu Zhu , Peikang Shen , Jinliang Zhu . Recent advances in copper-based materials for robust lithium polysulfides adsorption and catalytic conversion. Chinese Chemical Letters, 2024, 35(11): 109461-. doi: 10.1016/j.cclet.2023.109461
5. [5]
  Gengchen Guo , Tianyu Zhao , Ruichang Sun , Mingzhe Song , Hongyu Liu , Sen Wang , Jingwen Li , Jingbin Zeng . Au-Fe₃O₄ dumbbell-like nanoparticles based lateral flow immunoassay for colorimetric and photothermal dual-mode detection of SARS-CoV-2 spike protein. Chinese Chemical Letters, 2024, 35(6): 109198-. doi: 10.1016/j.cclet.2023.109198
6. [6]
  Xiao-Hong Yi , Chong-Chen Wang . Metal-organic frameworks on 3D interconnected macroporous sponge foams for large-scale water decontamination: A mini review. Chinese Chemical Letters, 2024, 35(5): 109094-. doi: 10.1016/j.cclet.2023.109094
7. [7]
  Haodong Wang , Xiaoxu Lai , Chi Chen , Pei Shi , Houzhao Wan , Hao Wang , Xingguang Chen , Dan Sun . Novel 2D bifunctional layered rare-earth hydroxides@GO catalyst as a functional interlayer for improved liquid-solid conversion of polysulfides in lithium-sulfur batteries. Chinese Chemical Letters, 2024, 35(5): 108473-. doi: 10.1016/j.cclet.2023.108473
8. [8]
  Longlong Geng , Huiling Liu , Wenfeng Zhou , Yong-Zheng Zhang , Hongliang Huang , Da-Shuai Zhang , Hui Hu , Chao Lv , Xiuling Zhang , Suijun Liu . Construction of metal-organic frameworks with unsaturated Cu sites for efficient and fast reduction of nitroaromatics: A combined experimental and theoretical study. Chinese Chemical Letters, 2024, 35(8): 109120-. doi: 10.1016/j.cclet.2023.109120
9. [9]
  Manoj Kumar Sarangi , L․D Patel , Goutam Rath , Sitansu Sekhar Nanda , Dong Kee Yi . Metal organic framework modulated nanozymes tailored with their biomedical approaches. Chinese Chemical Letters, 2024, 35(11): 109381-. doi: 10.1016/j.cclet.2023.109381
10. [10]
  Mengxiang Zhu , Tao Ding , Yunzhang Li , Yuanjie Peng , Ruiping Liu , Quan Zou , Leilei Yang , Shenglei Sun , Pin Zhou , Guosheng Shi , Dongting Yue . Graphene controlled solid-state growth of oxygen vacancies riched V₂O₅ catalyst to highly activate Fenton-like reaction. Chinese Chemical Letters, 2024, 35(12): 109833-. doi: 10.1016/j.cclet.2024.109833
11. [11]
  Qinghong Pan , Huafang Zhang , Qiaoling Liu , Donghong Huang , Da-Peng Yang , Tianjia Jiang , Shuyang Sun , Xiangrong Chen . A self-powered cathodic molecular imprinting ultrasensitive photoelectrochemical tetracycline sensor via ZnO/C photoanode signal amplification. Chinese Chemical Letters, 2025, 36(1): 110169-. doi: 10.1016/j.cclet.2024.110169
12. [12]
  Sixin Ai , Wenxiu Li , Huayong Zhu , Yang Wan , Weiying Lin . Viscosity-responsive signal amplification dual-modal probe triggered by cysteine/homocysteine for monitoring diabetic liver damages and repair processes. Chinese Chemical Letters, 2025, 36(3): 109904-. doi: 10.1016/j.cclet.2024.109904
13. [13]
  Yuxin Xiao , Xiaowei Wang , Yutong Yin , Fangchao Yin , Jinchao Li , Zhiyuan Hou , Mashooq Khan , Rusong Zhao , Wenli Wu , Qiongzheng Hu . Distance-based lateral flow biosensor for the quantitative detection of bacterial endotoxin. Chinese Chemical Letters, 2024, 35(12): 109718-. doi: 10.1016/j.cclet.2024.109718
14. [14]
  Liliang Chu , Xiaoyan Zhang , Jianing Li , Xuelei Deng , Miao Wu , Ya Cheng , Weiping Zhu , Xuhong Qian , Yunpeng Bai . Continuous-flow synthesis of polysubstituted γ-butyrolactones via enzymatic cascade catalysis. Chinese Chemical Letters, 2024, 35(4): 108896-. doi: 10.1016/j.cclet.2023.108896
15. [15]
  Zhaorui Song , Qiulian Hao , Bing Li , Yuwei Yuan , Shanshan Zhang , Yongkuan Suo , Hai-Hao Han , Zhen Cheng . NIR-Ⅱ fluorescence lateral flow immunosensor based on efficient energy transfer probe for point-of-care testing of tumor biomarkers. Chinese Chemical Letters, 2025, 36(1): 109834-. doi: 10.1016/j.cclet.2024.109834
16. [16]
  Neng Shi , Haonan Jia , Jixiang Zhang , Pengyu Lu , Chenglong Cai , Yixin Zhang , Liqiang Zhang , Nongyue He , Weiran Zhu , Yan Cai , Zhangqi Feng , Ting Wang . Accurate expression of neck motion signal by piezoelectric sensor data analysis. Chinese Chemical Letters, 2024, 35(9): 109302-. doi: 10.1016/j.cclet.2023.109302
17. [17]
  Kai Ye , Zhicheng Ye , Chuantao Wang , Zhilai Luo , Cheng Lian , Chunyan Bao . Artificial signal transduction triggered by molecular photoisomerization in lipid membranes. Chinese Chemical Letters, 2025, 36(4): 110033-. doi: 10.1016/j.cclet.2024.110033
18. [18]
  Ning LI , Siyu DU , Xueyi WANG , Hui YANG , Tao ZHOU , Zhimin GUAN , Peng FEI , Hongfang MA , Shang JIANG . Preparation and efficient catalysis for olefins epoxidation of a polyoxovanadate-based hybrid. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 799-808. doi: 10.11862/CJIC.20230372
19. [19]
  Ran Yu , Chen Hu , Ruili Guo , Ruonan Liu , Lixing Xia , Cenyu Yang , Jianglan Shui . 杂多酸H₃PW₁₂O₄₀高效催化MgH₂储氢. Acta Physico-Chimica Sinica, 2025, 41(1): 2308032-. doi: 10.3866/PKU.WHXB202308032
20. [20]
  Gaojian Yang , Zhiyang Li , Rabia Usman , Zhu Chen , Yuan Liu , Song Li , Hui Chen , Yan Deng , Yile Fang , Nongyue He . DNA walker induced "signal on" fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer. Chinese Chemical Letters, 2025, 36(2): 109930-. doi: 10.1016/j.cclet.2024.109930

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(25)
HTML views(6)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142