Citation: Lu-Lu He, Lan-Tu Xiong, Xin Wang, Yu-Zhen Li, Jia-Bao Li, Yu Shi, Xin Deng, Zi-Ning Cui. Application of inhibitors targeting the type III secretion system in phytopathogenic bacteria[J]. Chinese Chemical Letters, ;2025, 36(4): 110044. doi: 10.1016/j.cclet.2024.110044 shu

Application of inhibitors targeting the type III secretion system in phytopathogenic bacteria

Lu-Lu He ^{a, 1} ,
Lan-Tu Xiong ^{a, 1} ,
Xin Wang ^{a, 1} ,
Yu-Zhen Li ^a ,
Jia-Bao Li ^a ,
Yu Shi ^{a, b, c, *,} ,
Xin Deng ^{d, e} ,
Zi-Ning Cui ^{a, *,}

a.
National Key Laboratory of Green Pesticide, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China
b.
Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China
c.
Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University, Shaoguan 512005, China
d.
Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR 999077, China
e.
Shenzhen Research Institute, City University of Hong Kong, Shenzhen 518057, China

yushi201503@163.com

ziningcui@scau.edu.cn

Received Date: 14 March 2024
Revised Date: 19 May 2024
Accepted Date: 22 May 2024
Available Online: 23 May 2024

Figures(31)

Plant bacterial diseases have inflicted substantial economic losses in global crop, fruit, and vegetable production. The conventional methods for managing these diseases typically rely on the application of antibiotics. However, these antibiotics often target the growth factors of the pathogenic bacteria, leading to the accumulation and emergence of drug-resistant strains, which exacerbates antibiotic resistance. Innovative methods are urgently needed to treat and prevent the toxicity caused by these pathogenic bacteria. Targeting virulence mechanisms in pathogens is a globally recognized and effective strategy for mitigating bacterial resistance. Type III secretion system (T3SS) serves as a crucial virulence determinant in Gram-negative pathogens, and its non-essentials for pathogen growth renders it an ideal target. Targeting the T3SS holds significant potential to alleviate selective pressure for resistance mutations in pathogens. Therefore, targeting T3SS in pathogenic bacteria, while preserving their growth, has emerged as a novel avenue for the development of antimicrobial drugs. In recent years, a multitude of small molecular inhibitors targeting T3SS have been identified. This article offers a comprehensive review of T3SS inhibitors in plant pathogens, while also presenting the latest research advancements in this research direction.
- Phytopathogenic bacteria,
- Bacterial disease control,
- Virulence factor,
- Type III secretion system (T3SS),
- Inhibitors,
- Agricultural application
1. [1]
  A. Mohammad-Razdari, D. Rousseau, A. Bakhshipour, et al., Biosens. Bioelectron. 201 (2022) 113953.
2. [2]
  J. Shi, N. Luo, M. Ding, et al., Chin. Chem. Lett. 31 (2020) 434–438.
3. [3]
  H. Cao, Y. Yang, X. Chen, et al., Chin. Chem. Lett. 31 (2020) 1887–1889.
4. [4]
  A. Laine, Curr. Biol. 33 (2023) 574–583.
5. [5]
  G.W. Sundin, L.F. Castiblanco, X. Yuan, et al., Mol. Plant Pathol. 17 (2016) 1506–1518. doi: 10.1111/mpp.12436
6. [6]
  Y. Zheng, T. Zhang, P. Wang, et al., Chin. Chem. Lett. 28 (2017) 253–256.
7. [7]
  F. Vailleau, S. Genin, Annu. Rev. Phytopathol. 61 (2023) 25–47. doi: 10.1146/annurev-phyto-021622-104551
8. [8]
  S. Braun, G. Dilarri, L.C. de Lencastre Novaes, et al., Adv. Funct. Mater. 34 (2024) 2305646.
9. [9]
  Z. Liang, L. Huang, F. He, et al., Mbio 10 (2019) e00713–e00719.
10. [10]
  Y. Shi, Z. Zhang, J. Shao, et al., Chin. Chem. Lett. 35 (2024) 108794.
11. [11]
  W. Huang, P. Reyes-Caldas, M. Mann, et al., Mol. Plant. 13 (2020) 1379–1393.
12. [12]
  A.O. Charkowski, Annu. Rev. Phytopathol. 56 (2018) 269–288. doi: 10.1146/annurev-phyto-080417-045906
13. [13]
  X. Xin, B. Kvitko, S.Y. He, Nat. Rev. Microbiol. 16 (2018) 316–328. doi: 10.1038/nrmicro.2018.17
14. [14]
  Y. Wang, S. Guo, L. Yu, et al., Chin. Chem. Lett. 35 (2024) 108207.
15. [15]
  X. Wang, X. Fu, M. Chen, et al., Chin. Chem. Lett. 30 (2019) 1419–1422.
16. [16]
  Q. Wang, H. Song, Q. Wang, Chin. Chem. Lett. 33 (2022) 626–642.
17. [17]
  K.M. Bocian-Ostrzycka, M.J. Grzeszczuk, A.M. Banas, et al., Appl. Microbiol. ´ Biotechnol. 101 (2017) 3977–3989. doi: 10.1007/s00253-017-8291-8
18. [18]
  V.M. D'Costa, C.E. King, L. Kalan, et al., Nature 477 (2011) 457–461. doi: 10.1038/nature10388
19. [19]
  D.A. Rasko, V. Sperandio, Nat. Rev. Drug Discov. 9 (2010) 117–128. doi: 10.1038/nrd3013
20. [20]
  Y. Zhu, P. Li, C. Liu, et al., Chin. Chem. Lett. 34 (2023) 107543.
21. [21]
  H. Yao, L. Cui, H. Liu, et al., Chin. Chem. Lett. 35 (2024) 108511.
22. [22]
  N. Kurt Yilmaz, C.A. Schiffer, Chem. Rev. 121 (2021) 3235–3237.
23. [23]
  U. Theuretzbacher, K. Outterson, A. Engel, et al., Nat. Rev. Microbiol. 18 (2020) 275–285. doi: 10.1038/s41579-019-0288-0
24. [24]
  X.Y. Chen, S.H. Zhuang, W.Y. Yan, et al., Chin. Chem. Lett. 35 (2024) 109635. doi: 10.1016/j.cclet.2024.109635
25. [25]
  Y. Li, Y. Wang, Y. Luo, et al., Chin. Chem. Lett. 35 (2024) 109576. doi: 10.1016/j.cclet.2024.109576
26. [26]
  D.A. Gray, M. Wenzel, ACS Infect. Dis. 6 (2020) 1346–1365. doi: 10.1021/acsinfecdis.0c00001
27. [27]
  W. Fu, X. Hu, Q. Yuan, et al., Chin. Chem. Lett. 34 (2023) 108064.
28. [28]
  J. Vila, J. Moreno-Morales, C. Ballesté-Delpierre, Clin. Microbiol. Infect. 26 (2020) 596–603.
29. [29]
  V. Soheili, A.S. Tajani, R. Ghodsi, et al., Eur. J. Med. Chem. 172 (2019) 26–35.
30. [30]
  S. Li, P.H.M. Leung, X. Xu, et al., Chin. Chem. Lett. 29 (2018) 313–316.
31. [31]
  C. Feng, Y. Huang, W. He, et al., ACS Central Sci. 5 (2019) 1278–1288. doi: 10.1021/acscentsci.9b00452
32. [32]
  P. Zhang, W. Chen, Y.C. Ma, et al., J. Med. Chem. 66 (2023) 8441–8463. doi: 10.1021/acs.jmedchem.2c01866
33. [33]
  J. Sanchez-Garrido, D. Ruano-Gallego, J.S. Choudhary, et al., Trend. Microbiol. 30 (2022) 524–533.
34. [34]
  A. Anantharajah, M. Mingeot-Leclercq, F. Van Bambeke, Trends Pharmacol. Sci. 37 (2016) 734–749.
35. [35]
  P. Keyser, M. Elofsson, S. Rosell, et al., J. Intern. Med. 264 (2008) 17–29. doi: 10.1111/j.1365-2796.2008.01941.x
36. [36]
  T.L. Archuleta, B.W. Spiller, PLoS Pathog. 10 (2014) e1004498. doi: 10.1371/journal.ppat.1004498
37. [37]
  D. Hajra, A.V. Nair, D. Chakravortty, Phys. Life Rev. 38 (2021) 25–54.
38. [38]
  A. Diepold, E. Sezgin, M. Huseyin, et al., Nat. Commun. 8 (2017) 15940.
39. [39]
  W. Deng, N.C. Marshall, J.L. Rowland, et al., Nat. Rev. Microbiol. 15 (2017) 323–337. doi: 10.1038/nrmicro.2017.20
40. [40]
  Y. Sun, X. Shao, Y. Zhang, et al., Cell Biosci. 12 (2022) 147. doi: 10.1007/s11631-021-00516-9
41. [41]
  M. Chen, W. Zhang, L. Han, et al., Mol. Plant Pathol. 23 (2022) 679–692. doi: 10.1111/mpp.13189
42. [42]
  Z. Cui, R.B. Huntley, N.P. Schultes, et al., Mol. Plant Microbe Interact. 34 (2021) 1119–1127. doi: 10.1094/mpmi-06-21-0152-r
43. [43]
  L.J. Worrall, D.D. Majewski, N.C.J. Strynadka, Annu. Rev. Microbiol. 77 (2023) 669–698. doi: 10.1146/annurev-micro-032521-025503
44. [44]
  C.K. Yip, N.C.J. Strynadka, Trend. Biochem. Sci. 31 (2006) 223–230.
45. [45]
  I. Fishov, S. Namboodiri, Nat. Commun. 14 (2023) 1973.
46. [46]
  S. Dey, A. Chakravarty, P.G. Biswas, et al., Protein Sci. 28 (2019) 223–230.
47. [47]
  T. Kubori, Y. Matsushima, D. Nakamura, et al., Science 280 (1998) 602–605.
48. [48]
  K. Sekiya, M. Ohishi, T. Ogino, et al., Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 11638–11643.
49. [49]
  A. Collmer, J.L. Badel, A.O. Charkowski, et al., Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 8770–8777.
50. [50]
  E. Weber, R. Koebnik, J. Bacteriol. 188 (2006) 1405–1410.
51. [51]
  F. Van Gijsegem, J. Vasse, R. De Rycke, et al., Mol. Microbiol. 44 (2002) 935–946.
52. [52]
  D. BuÈttner, U. Bonas, EMBO J. 21 (2002) 5313–5322.
53. [53]
  J.R. Alfano, A. Collmer, J. Bacteriol. 179 (1997) 5655–5662. doi: 10.1128/jb.179.18.5655-5662.1997
54. [54]
  J.H. Ham, D.W. Bauer, D.E. Fouts, et al., Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 10206–10211.
55. [55]
  P.B. Lindgren, Annu. Rev. Phytopathol. 35 (1997) 129–152.
56. [56]
  D. Gürlebeck, F. Thieme, U. Bonas, J. Plant Physiol. 163 (2006) 233–255.
57. [57]
  A. Duque-Jaramillo, N. Ulmer, S. Alseekh, et al., New Phytol. 240 (2023) 1961–1975. doi: 10.1111/nph.19241
58. [58]
  J. Jayaraman, M. Yoon, L.M. Hemara, et al., New Phytol. 238 (2023) 1605–1619. doi: 10.1111/nph.18848
59. [59]
  J.B. Li, L.T. Xiong, Y.R. Lu, et al., Pest Manag. Sci. 79 (2023) 3666–3675. doi: 10.1002/ps.7545
60. [60]
  X. Tang, Y. Xiao, J. Zhou, Mol. Plant Microb. Interact. 19 (2006) 1159–1166.
61. [61]
  Y. Xie, X. Shao, X. Deng, Environ. Microbiol. 21 (2019) 4465–4477. doi: 10.1111/1462-2920.14779
62. [62]
  Y. Xiao, S.W. Hutcheson, J. Bacteriol. 176 (1994) 3089–3091. doi: 10.1128/jb.176.10.3089-3091.1994
63. [63]
  J. Huang, C. Yao, Y. Sun, et al., Comput. Struct. Biotechnol. J. 20 (2022) 6259–6270.
64. [64]
  Y. Xie, W. Liu, X. Shao, et al., Comput. Struct. Biotechnol. J. 18 (2020) 3415–3424.
65. [65]
  X. Zhang, M. Zhao, J. Yan, et al., Front. Microbiol. 9 (2018) 507.
66. [66]
  K. Wengelnik, G. Ackerveken, U. Bonas, Mol. Plant Microb. Interact. 9 (1996) 704–712.
67. [67]
  S. Fan, F. Tian, J. Li, et al., Mol. Plant Pathol. 18 (2017) 555–568. doi: 10.1111/mpp.12415
68. [68]
  D. Teper, S.S. Pandey, N. Wang, Microorganisms 9 (2021) 187. doi: 10.3390/microorganisms9010187
69. [69]
  N.G. Naga, D.E. El-Badan, K.M. Ghanem, et al., Cell Commun. Signal. 21 (2023) 133.
70. [70]
  M. Kumar, S. Jaiswal, K.K. Sodhi, et al., Environ. Int. 124 (2019) 448–461.
71. [71]
  M. Garland, S. Loscher, M. Bogyo, Chem. Rev. 117 (2017) 4422–4461. doi: 10.1021/acs.chemrev.6b00676
72. [72]
  X. Chen, J. Xue, X. Dong, et al., Appl. Environ. Microbiol. 89 (2023) e102823.
73. [73]
  S. Alharthi, S.E. Alavi, P.M. Moyle, et al., Drug Discov. Today 26 (2021) 2164–2172.
74. [74]
  A. Vashistha, N. Sharma, Y. Nanaji, et al., Bioorg. Chem. 136 (2023) 106551.
75. [75]
  V.C. Kalia, S.K.S. Patel, Y.C. Kang, et al., Biotechnol. Adv. 37 (2019) 68–90.
76. [76]
  L.N. Silva, K.R. Zimmer, A.J. Macedo, et al., Chem. Rev. 116 (2016) 9162–9236. doi: 10.1021/acs.chemrev.6b00184
77. [77]
  X. Liu, Y. Liu, X. Zhao, et al., Gut Microb. 16 (2024) 2316932.
78. [78]
  H. Guo, E.J. Geddes, T.J. Opperman, et al., ACS Infect. Dis. 9 (2023) 2652–2664. doi: 10.1021/acsinfecdis.3c00482
79. [79]
  Y. Zhang, Y. Liu, B. Zhang, et al., Food Funct. 13 (2022) 9761–9771. doi: 10.1039/d2fo00908k
80. [80]
  H.A. Pendergrass, A.E. May, Antibiotics 8 (2019) 162. doi: 10.3390/antibiotics8040162
81. [81]
  Q. Xu, H. Deng, X. Li, et al., Front. Chem. 9 (2021) 650569.
82. [82]
  Z. Lin, D. Chen, W. Liu, Sci. China Chem. 59 (2016) 1175–1187. doi: 10.1007/s11426-016-0062-x
83. [83]
  D. Cai, X. Li, J. Chen, et al., Food Chem. 366 (2022) 130611.
84. [84]
  H. Yao, J. Liu, S. Xu, et al., Expert. Opin. Drug Discov. 12 (2017) 121–140. doi: 10.1080/17460441.2016.1272757
85. [85]
  K. Li, Y. Zhu, W. Yan, et al., PLoS Pathog. 15 (2019) e1007673. doi: 10.1371/journal.ppat.1007673
86. [86]
  H.B. Felise, H.V. Nguyen, R.A. Pfuetzner, et al., Cell Host Microb 4 (2008) 325–336.
87. [87]
  Y. Li, Q. Peng, D. Selimi, et al., Appl. Environ. Microbiol. 75 (2009) 1223–1228.
88. [88]
  S. Yang, Q. Peng, F.M. San, et al., PLoS One 3 (2008) e2973. doi: 10.1371/journal.pone.0002973
89. [89]
  Y. Li, W. Hutchins, X. Wu, et al., Mol. Plant Pathol. 16 (2015) 150–163.
90. [90]
  A. Hu, M. Hu, S. Chen, et al., Front. Microbiol. 13 (2022) 839025.
91. [91]
  D. Khokhani, C. Zhang, Y. Li, et al., Appl. Environ. Microbiol. 79 (2013) 5424–5436.
92. [92]
  F. Yang, S.S. Korban, P.L. Pusey, et al., Mol. Plant Pathol. 15 (2014) 44–57. doi: 10.1111/mpp.12064
93. [93]
  X. Yuan, G.W. Sundin, Q. Zeng, et al., Phytopathology 113 (2023) 2197–2204. doi: 10.1094/phyto-04-23-0111-sa
94. [94]
  X. Xiang, H. Tao, S. Jiang, et al., Pest. Biochem. Physiol. 149 (2018) 89–97.
95. [95]
  H. Tao, S. Fan, S. Jiang, et al., Int. J. Mol. Sci. 20 (2019) 971. doi: 10.3390/ijms20040971
96. [96]
  H. Tao, H. Tian, S. Jiang, et al., Bioorg. Med. Chem. 27 (2019) 3364–3371.
97. [97]
  H. Tao, H. Tian, S. Jiang, et al., Pest. Biochem. Physiol. 160 (2019) 87–94.
98. [98]
  S. Jiang, H. Li, W. Ahmed, et al., Front. Microbiol. 10 (2019) 1874.
99. [99]
  S. Jiang, M. He, X. Xiang, et al., J. Agric. Food Chem. 67 (2019) 11867–11876. doi: 10.1021/acs.jafc.9b04085
100. [100]
  Y. Ma, L. Chen, N. Si, et al., Front. Plant Sci. 10 (2019) 1059.
101. [101]
  L. Zhou, C. Wang, G. Wang, et al., Appl. Environ. Microbiol. 86 (2020) e2319–e2349.
102. [102]
  D. Gao, H. Li, J. Shao, et al., J. Agric. Food Chem. 71 (2023) 9291–9301. doi: 10.1021/acs.jafc.3c00838
103. [103]
  X. Wang, L. He, Y. Zhang, et al., J. Agric. Food Chem. 71 (2023) 15971–15980. doi: 10.1021/acs.jafc.3c05212
104. [104]
  J. Zhu, J. Gao, C. Yang, et al., J. Agric. Food Chem. 68 (2020) 2306–2315. doi: 10.1021/acs.jafc.9b06793
105. [105]
  Y. Chen, H. Liu, S. Zhang, et al., J. Agric. Food Chem. 69 (2021) 1259–1271. doi: 10.1021/acs.jafc.0c06480
106. [106]
  J. Shao, Z. Zhang, Y. Shi, J. Agric. Food Chem. 72 (2024) 6988–6997. doi: 10.1021/acs.jafc.4c00214
107. [107]
  J.E. Kang, B.J. Jeon, M.Y. Park, et al., Pest Manag. Sci. 76 (2020) 2294–2303. doi: 10.1002/ps.5764
108. [108]
  W. Wang, J. Yang, J. Zhang, et al., Cell Host Microb. 27 (2020) 601–613. doi: 10.3390/s20030601
109. [109]
  L. He, X. Wang, D. O'Neill Rothenberg, et al., Pest. Biochem. Physiol. 194 (2023) 105471.
110. [110]
  M. Puigvert, M. Solé, B. López Garcia, et al., Mol. Plant Pathol. 20 (2019) 20–32. doi: 10.1111/mpp.12736
111. [111]
  L. Yang, S. Li, X. Qin, et al., Front. Microbiol. 8 (2017) 1234. doi: 10.1111/1556-4029.13389
112. [112]
  D. Wu, W. Ding, Y. Zhang, et al., Front. Microbiol. 6 (2015) 1466.
113. [113]
  Y. Zhang, J. Li, W. Zhang, et al., Front. Plant Sci. 8 (2017) 1595.
114. [114]
  Q.Q. Guo, Y.Z. Li, H.B. Shi, et al., Pest Manag. Sci. 79 (2023) 4626–4634.
1. [1]
  Zhi-Pei Sang , Teng Xue , Qian-Ru Xing , Qi-Yao Zhang , Hong-Song Chen , Xue Wang , Fu-Rong Zhang , Wen-Ling Fu , Wu Dong , Shu-Heng Huang , Yi-You Huang , Hai-Bin Luo . Discovery of α-mangostin derivatives as novel PDE4 inhibitors for the treatment of Alzheimer's disease: An artificial intelligence-driven synergized strategy. Chinese Chemical Letters, 2026, 37(5): 111318-. doi: 10.1016/j.cclet.2025.111318
2. [2]
  Jing Zhang , Charles Wang , Yaoyao Zhang , Haining Xia , Yujuan Wang , Kun Ma , Junfeng Wang . Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine. Chinese Chemical Letters, 2024, 35(10): 109420-. doi: 10.1016/j.cclet.2023.109420
3. [3]
  Zhaoyong Kang , Shen Li , Yan Li , Jingfeng Song , Yangrui Peng , Yihua Chen . Small molecular inhibitors and degraders targeting STAT3 for cancer therapy: An updated review (from 2022 to 2024). Chinese Chemical Letters, 2025, 36(7): 110447-. doi: 10.1016/j.cclet.2024.110447
4. [4]
  Han Yuan , Fengcai Zhang , Hongzhe Huang , Jiafei Wu , Yi Yang , Wanyi Huang , Dongjing Yang , Zhuoming Li , Zhe Li , Ling Huang , Yi-You Huang , Hai-Bin Luo , Lei Guo . Discovery of 3-trifluoromethyl-substituted pyrazoles as selective phosphodiesterase 10A inhibitors for orally attenuating isoprenaline-induced cardiac hypertrophy. Chinese Chemical Letters, 2025, 36(4): 109965-. doi: 10.1016/j.cclet.2024.109965
5. [5]
  Zhe-Han Yang , Jie Yin , Lei Xin , Yuanfang Li , Yijie Huang , Ruo Yuan , Ying Zhuo . Research advancement of DNA-based intelligent hydrogels: Manufacture, characteristics, application of disease diagnosis and treatment. Chinese Chemical Letters, 2024, 35(10): 109558-. doi: 10.1016/j.cclet.2024.109558
6. [6]
  Wenfeng Shao , Chuanlin Li , Chenggang Wang , Guangsen Du , Shunshun Zhao , Guangmeng Qu , Yupeng Xing , Tianshuo Guo , Hongfei Li , Xijin Xu . Stabilization of zinc anode by trace organic corrosion inhibitors for long lifespan. Chinese Chemical Letters, 2025, 36(3): 109531-. doi: 10.1016/j.cclet.2024.109531
7. [7]
  Muhammad Nafees , Muhammad Hanif , Piaoping Yang . Metallodrugs: From mere cytotoxic agents to immune modulators and checkpoint inhibitors. Chinese Chemical Letters, 2026, 37(4): 111013-. doi: 10.1016/j.cclet.2025.111013
8. [8]
  Weiqun Li , Ming-Jie Dong , Haibing Dai , Shanming Lu , Ran Luo , Jiahui Cao , Fan Zhang , Lin Mei , Jianbo Yu . Application of mitochondrial miRNA-204 nanoprobes in Alzheimer's disease treatment by clearing reactive oxygen species-mediated autophagy. Chinese Chemical Letters, 2025, 36(8): 110614-. doi: 10.1016/j.cclet.2024.110614
9. [9]
  Jie Wang , Jijie Zhang , Defang Ma , Zhenxiang Sun , Yan Wang , Qinyan Yue , Yanwei Li , Yue Gao , Baoyu Gao , Xing Xu . Simultaneous removal of tetracycline and antibiotic resistant bacteria/genes in UV-LED/H₂O₂ system: Competitive interactions and wavelength dependence. Chinese Chemical Letters, 2026, 37(2): 111209-. doi: 10.1016/j.cclet.2025.111209
10. [10]
  Shiqi Xu , Zi Ye , Shuang Shang , Fengge Wang , Huan Zhang , Lianguo Chen , Hao Lin , Chen Chen , Fang Hua , Chong-Jing Zhang . Pairs of thiol-substituted 1,2,4-triazole-based isomeric covalent inhibitors with tunable reactivity and selectivity. Chinese Chemical Letters, 2024, 35(7): 109034-. doi: 10.1016/j.cclet.2023.109034
11. [11]
  Mianling Yang , Meehyein Kim , Peng Zhan . Modular miniaturized synthesis and in situ biological evaluation facilitate rapid discovery of potent MraY inhibitors as antibacterial agents. Chinese Chemical Letters, 2025, 36(2): 110455-. doi: 10.1016/j.cclet.2024.110455
12. [12]
  Chunyu Yan , Qinglong Qiao , Wei Zhou , Xuelian Zhou , Yonghui Chen , Lu Miao , Zhaochao Xu . FRET-based in vitro assay for rapid detecting of SARS-CoV-2 entry inhibitors. Chinese Chemical Letters, 2025, 36(5): 110258-. doi: 10.1016/j.cclet.2024.110258
13. [13]
  Yi-You Huang , Xiang Luo , Kai Zhang , Yulan Liang , Furong Zhang , Guochao Liao , Shenghong Xie , Pei-Luo Huang , Siyu Hou , Qian Zhou , Yong Zou , Hai-Bin Luo . Structure-based optimization of isoaurostatin as novel PDE4 inhibitors with anti-fibrotic effects. Chinese Chemical Letters, 2025, 36(8): 110586-. doi: 10.1016/j.cclet.2024.110586
14. [14]
  Yifan Feng , Chengjuan Chen , Anqi Shao , Qingyang Zhang , Lan Sun , Hai-Yu Hu , Tiantai Zhang . Recent advances in interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors and PROTACs. Chinese Chemical Letters, 2025, 36(12): 110963-. doi: 10.1016/j.cclet.2025.110963
15. [15]
  Linan Wu , Shenghua Gao , Peng Zhan . Breakthrough progress in the structural determination of the monkeypox virus I7L protease and the design of targeted inhibitors. Chinese Chemical Letters, 2026, 37(4): 111845-. doi: 10.1016/j.cclet.2025.111845
16. [16]
  Deyan Wu , Qingjiang Ma , Yanquan Chen , Guofeng Yang , Fengcai Zhang , Meiyan Jiang , Xue Wang , Xingfu Liu , Qian Zhou , Yi-You Huang , Zhe Li , Hai-Bin Luo . Plasma metabolites-based drug design: Discovery of novel and highly selective phosphodiesterase 5 inhibitors. Chinese Chemical Letters, 2026, 37(5): 111236-. doi: 10.1016/j.cclet.2025.111236
17. [17]
  Huijuan Luo , Haiyue Zuo , Jianzhong Zhu , Juanjuan Zhao , Roufen Chen , Xinle Yang , Fangqi Cao , Ruohan Lou , Xiaowu Dong , Yangyang Bian , Ligen Lin . Computer-aided discovery of peptidyl arginine deiminase 4 inhibitors to suppress NETosis and accelerate diabetic wound healing. Chinese Chemical Letters, 2026, 37(6): 111510-. doi: 10.1016/j.cclet.2025.111510
18. [18]
  Anxiang Yang , Sunkai Gu , Ziyi Jiao , Yuhao Feng , Hui Sun , Guanyu Yang , Minghui Gao , Tao Zeng , Benxin Hou , Ling Huang , Xiaokun Wang , Congjun Xu , Haibin Luo . Discovery of 2-oxopiperazine derivatives as novel GPX4 inhibitors for the treatment of oral cancer. Chinese Chemical Letters, 2026, 37(9): 112063-. doi: 10.1016/j.cclet.2025.112063
19. [19]
  Peishuang Yu , Bohan Chen , Bingyu Xie , Mengjiao Zhou , Chengying Wang , Shenshen Yang , Wei Huang , Yubo Li . Recent advances in oral hydrogel drug delivery system for disease treatment. Chinese Chemical Letters, 2026, 37(7): 111695-. doi: 10.1016/j.cclet.2025.111695
20. [20]
  Doudou Liu , Weiwei Guo , Guoliang Mei , Youpeng Dan , Rong Yang , Chao Huang , Yanling Zhai , Xiaoquan Lu . Application of catalyst Cu-t-ZrO₂ based on the electronic metal-support interaction in electrocatalytic nitrate reduction. Chinese Chemical Letters, 2025, 36(8): 110578-. doi: 10.1016/j.cclet.2024.110578

Get Citation

PDF

XML

Metrics

PDF Downloads(11)
Abstract views(2867)
HTML views(110)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142