Citation: Min Liu, Bin Feng, Feiyi Chu, Duoyang Fan, Fan Zheng, Fei Chen, Wenbin Zeng. An ESIPT-boosted NIR nanoprobe for ratiometric sensing of carbon monoxide via activatable aggregation-induced dual-color fluorescence[J]. Chinese Chemical Letters, ;2025, 36(5): 110043. doi: 10.1016/j.cclet.2024.110043 shu

An ESIPT-boosted NIR nanoprobe for ratiometric sensing of carbon monoxide via activatable aggregation-induced dual-color fluorescence

Min Liu ^{a, b, c, d, *,} ,
Bin Feng ^{b, d} ,
Feiyi Chu ^{b, d} ,
Duoyang Fan ^{b, d} ,
Fan Zheng ^{b, d} ,
Fei Chen ^{b, d} ,
Wenbin Zeng ^{b, d, *,}

a.
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China
b.
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
c.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
d.
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha 410013, China

xyliumin@csu.edu.cn

wbzeng@csu.edu.cn

Received Date: 18 March 2024
Revised Date: 21 May 2024
Accepted Date: 22 May 2024
Available Online: 23 May 2024

Figures(5)

Carbon monoxide (CO) is a crucial gaseous signaling molecule that regulates various physiological and pathological processes, and may exert an anti-inflammatory and protective role in drug-induced liver injury (DILI). Despite this, understanding the exact relationship between CO and the occurrence and development of DILI remains challenging. Hence, there is an urgent need to develop a reliable and robust tool for the rapid visual detection and assessment of CO in this context. Herein, we presented a novel near-infrared (NIR) fluorescent nanoprobe with aggregation-induced emission (AIE) properties and excited-state intramolecular proton transfer (ESIPT) characteristics for the detection and imaging of CO both in vitro and in vivo. Simultaneously, the nanoprobe enables self-assembly form nanoaggregates in aqueous media with high biocompatible, which can sense CO in situ through the conversion of yellow-to-red fluorescence facilitated aggregation-induced dual-color fluorescence. What is more, this nanoprobe shows ratiometric respond to CO, which demonstrates excellent stability, high sensitivity (with a detection limit of 12.5 nmol/L), and superior selectivity. Crucially, this nanoprobe enables the visual detection of exogenous and endogenous CO in living cells and tissues affected by DILI, offering a user-friendly tool for real-time visualization of CO in living system. Hence, it holds great promise in advancing our understanding of CO's role.
- Aggregation-induced emission,
- Excited-state intramolecular proton transfer,
- Activatable nanoprobe,
- Carbon monoxide,
- Imaging,
- Assessment
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