Citation: Shuxin Liu, Jinjuan Ma, Aiguo Wang, Nan Zheng. Decomposable and sono-enzyme co-triggered poly(sonosensitizers) for precise and hypotoxic sonodynamic therapy[J]. Chinese Chemical Letters, ;2025, 36(4): 110032. doi: 10.1016/j.cclet.2024.110032 shu

Decomposable and sono-enzyme co-triggered poly(sonosensitizers) for precise and hypotoxic sonodynamic therapy

Shuxin Liu ^a ,
Jinjuan Ma ^b ,
Aiguo Wang ^b ,
Nan Zheng ^{a, *,}

a.
School of Chemical Engineering, Cancer Hospital of Dalian University of Technology, Dalian University of Technology, Dalian 116023, China
b.
Department of Comparative Medicine Laboratory Animal Center, Dalian Medical University, Dalian 116000, China

nzheng@dlut.edu.cn

Received Date: 28 March 2024
Revised Date: 15 May 2024
Accepted Date: 20 May 2024
Available Online: 21 May 2024

Figures(5)

A decomposable and sono-enzyme co-triggered nanoparticle (pTCP-CR NP) with “AND gate” logic was synthesized, combining a meso‑carboxyl-porphyrin-based sonosensitizer (5,10,15,20-tetrakis(carboxyl)porphyrin, TCP) and a thiophenyl-croconium (2,5-bis[(2-(2-(2-hydroxyethoxy)ethoxy)ethyl-4-carboxylate-piperidylamino)thiophenyl]-croconium, CR) via ester groups. TCP releases carbon monoxide (CO) under ultrasound (US) irradiation, offering both sonodynamic and gas therapy. CR decomposes into stronger reactive oxygen species (ROS) compared to oxygen-based radicals. The Förster resonance energy transfer (FRET) effect between TCP and CR inhibits ROS and CO generation until triggered by tumor cell overexpressed carboxylesterase (CEs). pTCP-CR NPs “AND gate” logic ensures activation only in the presence of both CEs and US, targeting tumor cells while safety in normal tissues. The ROS and CO generation abilities, as well as the releasing of SO₄^•− have been systemically examined. pTCP-CR can be thoroughly decomposed into low-toxic molecules post the treatment, showing the safety with negligible phototoxic reactions. In vivo anti-cancer therapy has been evaluated using mice bearing hepatocellular carcinoma.
- “AND gate” logic,
- Hypotoxic sonodynamic therapy,
- Ultrasound and enzyme co-trigger,
- Sulfate radicals,
- Förster resonance energy transfer effect
1. [1]
  R.H. Zhang, T.Q. Nie, L.Y. Wang, et al., Biomater. Sci. 11 (2023) 4254–4264. doi: 10.1039/d3bm00461a
2. [2]
  Y. Zhuang, S. Han, Y. Fang, et al., Coordin. Chem. Rev. 455 (2022) 214360. doi: 10.1016/j.ccr.2021.214360
3. [3]
  Y. Tao, C. Dai, Z. Xie, et al., Chin. Chem. Lett. 35 (2023) 109170. doi: 10.1016/j.cclet.2023.109170
4. [4]
  H. Liu, T. Nie, X. Duan, et al., J. Control. Release 359 (2023) 132–146. doi: 10.1016/j.jconrel.2023.05.040
5. [5]
  G. Yang, Y. Liu, J. Chen, et al., Acc. Mater. Res. 3 (2022) 1232–1247. doi: 10.1021/accountsmr.2c00147
6. [6]
  H.Z. He, L.H. Du, M. Tan, et al., Sci. China Chem. 63 (2020) 936–945. doi: 10.1007/s11426-020-9735-2
7. [7]
  J.H. Xie, S.Y. Tian, H.N. Zhang, et al., Biomacromolecules 24 (2023) 2225–2236. doi: 10.1021/acs.biomac.3c00134
8. [8]
  J. Zhang, J. Yan, Y. Wang, et al., Chin. Chem. Lett. 35 (2024) 108434. doi: 10.1016/j.cclet.2023.108434
9. [9]
  Z. Wang, M. Wang, Y. Qian, et al., Chin. Chem. Lett. 34 (2023) 107853. doi: 10.1016/j.cclet.2022.107853
10. [10]
  H. Wang, Z. Xu, Q. Li, et al., Eng. Regener. 2 (2021) 137–153. doi: 10.1504/ijvics.2021.10038095
11. [11]
  M. Chen, C. Wang, X. Wang, et al., Adv. Mater. 36 (2024) e2307818. doi: 10.1002/adma.202307818
12. [12]
  C. Luo, L. He, F.M. Chen, et al., Cell Rep. Phys. Sci. 2 (2021) 100350. doi: 10.1016/j.xcrp.2021.100350
13. [13]
  J.T.F. Lau, P.C. Lo, X.J. Jiang, et al., J. Med. Chem. 57 (2014) 4088–4097. doi: 10.1021/jm500456e
14. [14]
  H. Xiong, K.J. Zhou, Y.F. Yan, et al., ACS Appl. Mater. Interface 10 (2018) 16335–16343. doi: 10.1021/acsami.8b04710
15. [15]
  L.G. Tang, Z. Yang, Z.J. Zhou, et al., Theranostics 9 (2019) 1358–1368. doi: 10.7150/thno.32106
16. [16]
  M.Q. Chen, C.H. Wang, Z.X. Ding, et al., ACS Cent. Sci. 8 (2022) 837–844. doi: 10.1021/acscentsci.2c00387
17. [17]
  C.X. Yan, Z.Q. Guo, Y.J. Liu, et al., Chem. Sci. 9 (2018) 6176–6182. doi: 10.1039/c8sc02079e
18. [18]
  S. Ozlem, E.U. Akkaya, J. Am. Chem. Soc. 131 (2009) 48–49. doi: 10.1021/ja808389t
19. [19]
  D. Huang, J. Wang, C. Song, et al., Innovation 4 (2023) 100421.
20. [20]
  C.T. Deng, M.C. Zheng, S.P. Han, et al., Adv. Funct. Mater. 33 (2023) 2300348. doi: 10.1002/adfm.202300348
21. [21]
  S.X. Liu, J.J. Ma, E.Y. Xue, et al., Adv. Healthc. Mater. 12 (2023) 2300481. doi: 10.1002/adhm.202300481
22. [22]
  X.T. Pan, N. Wu, S.Y. Tian, et al., Adv. Funct. Mater. 32 (2022) 2112145. doi: 10.1002/adfm.202112145
23. [23]
  Y. Zhang, X.Q. Zhang, H.C. Yang, et al., Chem. Soc. Rev. 50 (2021) 11227–11248. doi: 10.1039/d1cs00403d
24. [24]
  E.G. Kaye, B. Mirabi, I.R. Lopez-Miranda, et al., J. Am. Chem. Soc. 145 (2023) 12518–12531. doi: 10.1021/jacs.3c00398
25. [25]
  G.C. Wang, Y. Su, X.L. Chen, et al., Bioact. Mater. 25 (2023) 189–200.
26. [26]
  L.K.B. Tam, J.C.H. Chu, L. He, et al., J. Am. Chem. Soc. 145 (2023) 7361–7375. doi: 10.1021/jacs.2c13732
27. [27]
  S. Son, J.H. Kim, X.W. Wang, et al., Chem. Soc. Rev. 49 (2020) 3244–3261. doi: 10.1039/c9cs00648f
28. [28]
  S. Liang, X.R. Deng, P.A. Ma, et al., Adv. Mater. 32 (2020) 2003214. doi: 10.1002/adma.202003214
29. [29]
  S. Liu, J. Ma, X. Xu, et al., Sci. China Chem. 67 (2024)1624–1635. doi: 10.1007/s11426-023-1917-8
30. [30]
  X.D. Duan, X.X. Niu, J. Gao, et al., Curr. Opin. Chem. Eng. 38 (2022) 100867. doi: 10.1016/j.coche.2022.100867
31. [31]
  C. Agarkoti, A. Chaturvedi, P.R. Gogate, et al., Sep. Purif. Technol. 312 (2023) 123351. doi: 10.1016/j.seppur.2023.123351
32. [32]
  X.J. Yu, J. Zhang, Y.Y. Chen, et al., J. Environ. Chem. Eng. 9 (2021) 106161. doi: 10.1016/j.jece.2021.106161
33. [33]
  T. Nie, H. Liu, Z. Fang, et al., ACS Nano 17 (2023) 10925–10937. doi: 10.1021/acsnano.3c02803
34. [34]
  M. Tian, S. Tatsuura, M. Furuki, et al., J. Am. Chem. Soc. 125 (2003) 348–349. doi: 10.1021/ja0209666
35. [35]
  Z. Zhou, T. Wang, T.T. Hu, et al., Mater. Chem. Front. 7 (2023) 1684–1693. doi: 10.1039/d2qm01333a
36. [36]
  T. Li, Y.M. Chen, X.M. Wang, et al., Appl. Catal. B: Environ. 285 (2021) 119830.
37. [37]
  S.M. Wu, P. Wang, J.W. Qin, et al., Adv. Funct. Mater. 31 (2021) 2102160.
38. [38]
  N. Zheng, Z.Y. Zhang, J. Kuang, et al., ACS Appl. Mater. Interface 11 (2019) 18224–18232. doi: 10.1021/acsami.9b04351
39. [39]
  Z. Sun, Y. Hou, BMEMat 1 (2023) e12012.
40. [40]
  W.C.W. Chan, BME Front. 4 (2023) 0016. doi: 10.34133/bmef.0016
41. [41]
  M.C. Dos Santos, W.R. Algar, I.L. Medintz, et al., Trends Anal. Chem. 125 (2020) 115819.
42. [42]
  J. Qian, H.N. Cui, X.T. Lu, et al., Chem. Eng. J. 401 (2020) 126017.
43. [43]
  T. Entradas, S. Waldron, M. Volk, J. Photoch. Photobiol. B: Biol. 204 (2020) 111787.
44. [44]
  K. Na, M. Kim, C.Y. Kim, et al., J. Proteome. Res. 19 (2020) 4867–4883. doi: 10.1021/acs.jproteome.0c00787
45. [45]
  J.J. Tan, Z.Y. Deng, C.Z. Song, et al., J. Am. Chem. Soc. 143 (2021) 13738–13748. doi: 10.1021/jacs.1c05617
46. [46]
  J.J. Chen, Z.Y. Jiang, Y.S. Zhang, et al., Appl. Phys. Rev. 8 (2021) 041321.
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