Citation: Xi Chen, Xue Zhang, Shuai Yang, Jie Wang, Tian Tang, Maling Gou. An adhesive hydrogel for the treatment of oral ulcers[J]. Chinese Chemical Letters, ;2025, 36(3): 110021. doi: 10.1016/j.cclet.2024.110021 shu

An adhesive hydrogel for the treatment of oral ulcers

Xi Chen ^{a, 1} ,
Xue Zhang ^{b, 1} ,
Shuai Yang ^{b, 1} ,
Jie Wang ^b ,
Tian Tang ^{a, *,} ,
Maling Gou ^{b, *,}

a.
State Key Laboratory of Oral Disease & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
b.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China

tangtian05@163.com

goumaling@scu.edu.cn

Received Date: 16 January 2024
Revised Date: 14 May 2024
Accepted Date: 16 May 2024
Available Online: 17 May 2024

Figures(5)

Oral ulcers are a common ulcerative injury that occurs in the oral mucosa. When occurring, they can cause mucosal pain and affect eating and communication. The oral cavity, characterized by its moist environment and constant movement of the lips and tongue, presents challenges for conventional drug delivery systems due to its suboptimal adhesion. Therefore, there is a need for the development of adhesive materials specifically designed for use within the oral cavity. In this research, a sticky coacervate incorporating tea polyphenols (TP) was formulated based on the adhesive properties observed in sandcastle worms. The coacervate is composed of Pluronic F68 (F68) and TP, synthesized through the coacervation reaction. The F68-TP coacervates are attached to porcine skin easily. It also reduces bacterial viability and has the ability to clear reactive oxygen species. In animal ulcer models, these coacervates demonstrate anti-inflammatory effects and enhance collagen and muscle fiber synthesis. Overall, these adhesive coacervates with antioxidative and antibacterial properties hold potential as a therapeutic option for oral ulcers in the oral cavity.
- Tea polyphenols,
- Pluronic F68,
- Oral ulcers,
- Hydrogel,
- Coacervate
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