Citation: Yue Sun, Yingnan Zhu, Jiahang Si, Ruikang Zhang, Yalan Ji, Jinjie Fan, Yuze Dong. Glucose-activated nanozyme hydrogels for microenvironment modulation via cascade reaction in diabetic wound[J]. Chinese Chemical Letters, ;2025, 36(4): 110012. doi: 10.1016/j.cclet.2024.110012 shu

Glucose-activated nanozyme hydrogels for microenvironment modulation via cascade reaction in diabetic wound

School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Center for Drug Safety Evaluation and Research, Zhengzhou University, Zhengzhou 450001, China

dongyuze@zzu.edu.cn

Received Date: 6 March 2024
Revised Date: 10 May 2024
Accepted Date: 14 May 2024
Available Online: 15 May 2024

Figures(4)

Wound healing in diabetic patients presents significant challenges due to heightened risks of bacterial infection, elevated glucose levels, and insufficient angiogenesis. Nanozymes are widely employed for wound healing, but most current nanozyme systems exhibit only moderate activity limited by incompatible reaction microenvironments including pH and hydrogen peroxide (H₂O₂) concentration. Herein, a glucose-activated nanozyme hydrogel was developed using bovine serum albumin (BSA)-modified gold nanoparticles (Au NPs) attached to a two-dimensional (2D) metal-organic framework (MOF) (Cu-TCPP(Fe)@Au@BSA) by an in situ growth method. The Au NPs function as a glucose oxidase (GOx)-like enzyme, converting glucose to gluconic acid and H₂O₂, triggering the peroxidase (POD)-like activity of Cu-TCPP(Fe) to produce hydroxyl radicals (^•OH), effectively eliminating bacteria. Additionally, the modification of BSA reduces the Au NP size, enhancing enzyme activity. Both in vitro and in vivo tests demonstrate that this nanozyme hydrogel can be activated by the microenvironment to lower blood glucose, eliminate bacterial infections, and promote epithelial formation and collagen deposition, thus accelerating diabetic wound healing effectively. The multifunctional nanozyme hydrogel dressing developed in this study presents a promising therapeutic approach to enhance diabetic wound healing.
- Metal-organic frameworks,
- Hybrid nanozyme,
- Glucose cascade reaction,
- Hydrogel,
- Diabetic wound healing
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