Citation: Han Wu, Yumei Wang, Zekai Ren, Hailin Cong, Youqing Shen, Bing Yu. The nanocarrier strategy for crossing the blood-brain barrier in glioma therapy[J]. Chinese Chemical Letters, ;2025, 36(4): 109996. doi: 10.1016/j.cclet.2024.109996 shu

The nanocarrier strategy for crossing the blood-brain barrier in glioma therapy

Han Wu ^a ,
Yumei Wang ^a ,
Zekai Ren ^a ,
Hailin Cong ^{a, c} ,
Youqing Shen ^{a, d} ,
Bing Yu ^{a, b, *,}

a.
College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China
b.
State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China
c.
School of Materials Science and Engineering, Shandong University of Technology, Zibo 255000, China
d.
Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China

yubing198@qdu.edu.cn

Received Date: 8 March 2024
Revised Date: 7 May 2024
Accepted Date: 10 May 2024
Available Online: 11 May 2024

Figures(2)

Glioma is the most common malignant tumor of the brain. The postoperative recurrence rate was high, and the 2-year survival rate only increased by 20%–25%. The reason is the blood-brain barrier (BBB). BBB is a physical barrier that stabilizes the physiological environment of brain tissue and protects the central nervous system from the invasion of harmful substances. Drug delivery based on nanotechnology and nanocarriers has attracted much attention due to its biological safety, continuous drug release time, increasing solubility, biological drug activity, and enhanced BBB permeability. By modifying different substances on the surface of nanocarriers, the BBB is bypassed by receptor-mediated and cell endocytosis and exocytosis. In addition, the purpose of bypassing BBB-targeted drug delivery can also be achieved by intranasal administration and local administration. This paper reviews different target transport mechanisms, mainly in invasive and non-invasive strategies, the nanocarriers that have made progress and the nanocarrier strategy of bypassing BBB are listed.
- Glioma,
- Blood-brain barrier,
- Nanocarriers,
- Drug delivery,
- Adsorption-mediated transport,
- Receptor-mediated transport
1. [1]
  J. Kreuter, Adv. Drug Deliv. Rev. 64 (2012) 213–222. doi: 10.1016/j.addr.2012.09.015
2. [2]
  C. Abbruzzese, S. Matteoni, M. Signore, et al., J. Exp. Clin. Cancer Res. 36 (2017) 169. doi: 10.1186/s13046-017-0642-x
3. [3]
  S. Reddy, K. Tatiparti, S. Sau, A.K. Iyer, Drug. Discov. Today 26 (2021) 1944–1952. doi: 10.1016/j.drudis.2021.04.008
4. [4]
  S. Ostermann, C. Csajka, T. Buclin, et al., Clin. Cancer Res. 10 (2004) 3728–3736. doi: 10.1158/1078-0432.CCR-03-0807
5. [5]
  J. Portnow, B. Badie, M. Chen, et al., Clin. Cancer Res. 15 (2009) 7092–7098. doi: 10.1158/1078-0432.CCR-09-1349
6. [6]
  R. Stupp, W.P. Mason, M.J.v.d. Bent, et al., N. Engl. J. Med. 352 (2005) 987–996. doi: 10.1056/NEJMoa043330
7. [7]
  G.A. Silva, Surg. Neurol. 67 (2007) 113–116. doi: 10.1016/j.surneu.2006.08.033
8. [8]
  A. García-Fernández, F. Sancenón, R. Martínez-Máñez, Adv. Drug Deliv. Rev. 177 (2021) 113953. doi: 10.1016/j.addr.2021.113953
9. [9]
  P. Liu, C. Jiang, WIREs Nanomed. Nanobiotechnol. 14 (2022) e1818. doi: 10.1002/wnan.1818
10. [10]
  L. Shen, H. Liu, M. Jin, et al., Chin. Chem. Lett. 35 (2024) 109572. doi: 10.1016/j.cclet.2024.109572
11. [11]
  P. Wang, Y. Wang, P. Li, et al., Chin. Chem. Lett. 34 (2023) 107691. doi: 10.1016/j.cclet.2022.07.034
12. [12]
  N. McDannold, C.D. Arvanitis, N. Vykhodtseva, M.S. Livingstone, Cancer Res. 72 (2012) 3652–3663.
13. [13]
  G.J.A. Murad, S. Walbridge, P.F. Morrison, et al., Clin. Cancer Res. 12 (2006) 3145–3151. doi: 10.1158/1078-0432.CCR-05-2583
14. [14]
  C.B. Brown, S. Jacobs, M.P. Johnson, C. Southerland, S. Threatt, Semin. Oncol. Nurs. 34 (2018) 494–500. doi: 10.1016/j.soncn.2018.10.004
15. [15]
  B.S. Karmur, J. Philteos, A. Abbasian, et al., Front. Oncol. 10 (2020) 563840. doi: 10.3389/fonc.2020.563840
16. [16]
  A. Furquan, A. Hafeez, M.A. Rahman, J. Nanopart. Res. 25 (2023) 233. doi: 10.1007/s11051-023-05880-6
17. [17]
  Y. Jiang, X. Pan, T. Yu, H. Wang, Nano Res. 16 (2023) 13077–13099. doi: 10.1007/s12274-023-6026-y
18. [18]
  E. Marcello, V. Chiono, Int. J. Mol. Sci. 24 (2023) 3390. doi: 10.3390/ijms24043390
19. [19]
  Q. Tang, G. Zhao, H. Fang, et al., Acta Pharm. Sin. B 14 (2024) 2786–2789. doi: 10.1016/j.apsb.2024.03.023
20. [20]
  D. Liu, X. Dai, Z. Tao, et al., Cancer Nanotechnol 14 (2023) 58. doi: 10.1039/d2ce01263d
21. [21]
  S. Zha, H. Liu, H. Li, et al., ACS Nano 18 (2024) 1820–1845. doi: 10.1021/acsnano.3c10674
22. [22]
  V. Kurawattimath, B. Wilson, K.M. Geetha, OpenNano 10 (2023) 100128. doi: 10.1016/j.onano.2023.100128
23. [23]
  M. Beygi, F. Oroojalian, S. Azizi-Arani, et al., Adv. Funct. Mater. 34 (2024) 2310881. doi: 10.1002/adfm.202310881
24. [24]
  W. Zhang, A. Mehta, Z. Tong, L. Esser, N.H. Voelcker, Adv. Sci. 8 (2021) 2003937. doi: 10.1002/advs.202003937
25. [25]
  Y.H. Song, R. De, K.T. Lee, Adv. Colloid Interface Sci. 320 (2023) 103008. doi: 10.1016/j.cis.2023.103008
26. [26]
  A. Cox, D. Vinciguerra, F. Re, et al., Eur. J. Pharm. Biopharm. 142 (2019) 70–82. doi: 10.1016/j.ejpb.2019.06.004
27. [27]
  R. Yu, S. Wen, Q. Wang, et al., J. Neurochem. 157 (2021) 1979–1991. doi: 10.1111/jnc.15242
28. [28]
  J. Firkins, P. Ambady, J.A. Frank, E.A. Neuwelt, J. Clin. Oncol. 36 (2018) e14056. doi: 10.1200/JCO.2018.36.15_suppl.e14056
29. [29]
  M. Kinoshita, N. McDannold, F.A. Jolesz, K. Hynynen, Biochem. Biophys. Res. Commun. 340 (2006) 1085–1090. doi: 10.1016/j.bbrc.2005.12.112
30. [30]
  R. Suzuki, Y. Oda, N. Utoguchi, K. Maruyama, J. Control. Release 149 (2011) 36–41. doi: 10.1016/j.jconrel.2010.05.009
31. [31]
  A.B. Etame, R.J. Diaz, C.A. Smith, et al., Neurosurg. Focus 32 (2012) E3.
32. [32]
  S.A. Quadri, M. Waqas, I. Khan, et al., Neurosurg. Focus 44 (2018) E16. doi: 10.3171/2017.11.focus17610
33. [33]
  V. Krishna, F. Sammartino, A. Rezai, JAMA Neurol 75 (2018) 246–254. doi: 10.1001/jamaneurol.2017.3129
34. [34]
  A. Carpentier, M. Canney, A. Vignot, et al., Sci. Transl. Med. 8 (2016) 343re2.
35. [35]
  K. Beccaria, M. Canney, L. Goldwirt, et al., J. Neurosurg. 119 (2013) 887–898. doi: 10.3171/2013.5.JNS122374
36. [36]
  T. Niibo, H. Ohta, S. Miyata, et al., Stroke 48 (2017) 117–122. doi: 10.1161/STROKEAHA.116.013923
37. [37]
  R.L. Lee, K.E. Funk, Front. Aging Neurosci. 15 (2023) 1144036. doi: 10.3389/fnagi.2023.1144036
38. [38]
  R. Gabathuler, Neurobiol. Dis. 37 (2010) 48–57. doi: 10.1016/j.nbd.2009.07.028
39. [39]
  R.H. Bobo, D.W. Laske, A. Akbasak, et al., Neurosurgery 91 (1994) 2076–2080. doi: 10.1073/pnas.91.6.2076
40. [40]
  A.H. Faraji, A. Jaquins-Gerstl, A.C. Valenta, et al., Neurosurgery 65 (2018) 136. doi: 10.1093/neuros/nyy303.340
41. [41]
  G. Xi, E. Robinson, B. Mania-Farnell, et al., Nanomed. Nanotech. Biol. Med. 10 (2014) 381–391. doi: 10.1016/j.nano.2013.07.013
42. [42]
  C.S. Lee, K.W. Leong, Curr. Opin. Biotech. 66 (2020) 78–87. doi: 10.1016/j.copbio.2020.06.009
43. [43]
  J.I. Griffith, J.N. Sarkaria, W.F. Elmquist, Trends Pharmacol. Sci. 42 (2021) 426–428. doi: 10.1016/j.tips.2021.03.001
44. [44]
  E.K. Nduom, C. Yang, M.J. Merrill, Z. Zhuang, R.R. Lonser, J. Neurosurg. 119 (2013) 427–433. doi: 10.3171/2013.3.JNS122226
45. [45]
  G.M. Bernal, M.J. LaRiviere, N. Mansour, et al., Nanomed. Nanotech. Biol. Med. 10 (2014) 149–157.
46. [46]
  A.M. Sonabend, A.S. Carminucci, B. Amendolara, et al., Neuro Oncol. 16 (2014) 1210–1219. doi: 10.1093/neuonc/nou026
47. [47]
  H. Wu, Y. Zhou, Y. Wang, et al., Front. Pharmacol. 12 (2021) 717192. doi: 10.3389/fphar.2021.717192
48. [48]
  A.R. Khan, M. Liu, M.W. Khan, G. Zhai, J. Control. Release 268 (2017) 364–389. doi: 10.1016/j.jconrel.2017.09.001
49. [49]
  S.U. Islam, A. Shehzad, M.B. Ahmed, Y.S. Lee, Molecules 25 (2020) 1929. doi: 10.3390/molecules25081929
50. [50]
  Y.T. Zhang, K.J. He, J.B. Zhang, et al., Stem Cell Res. Ther. 12 (2021) 210. doi: 10.1186/s13287-021-02274-0
51. [51]
  A.S. Fatani, A. Petkova, A.G. Schatzlein, I.F. Uchegbu, Int. J. Pharm. 644 (2023) 123343. doi: 10.1016/j.ijpharm.2023.123343
52. [52]
  F. Anton, P. Peppel, Neuroscience 41 (1991) 617–628. doi: 10.1016/0306-4522(91)90354-Q
53. [53]
  A. Haasbroek-Pheiffer, S. Van Niekerk, F. Van der Kooy, et al., Biopharm. Drug Dispos. 44 (2023) 94–112. doi: 10.1002/bdd.2348
54. [54]
  S.V. Dhuria, L.R. Hanson, W.H. Frey, J. Pharm. Sci. 99 (2010) 1654–1673. doi: 10.1002/jps.21924
55. [55]
  N.A. Emad, B. Ahmed, A. Alhalmi, N. Alzobaidi, S.S. Al-Kubati, J. Drug Deliv. Sci. Technol. 64 (2021) 102642. doi: 10.1016/j.jddst.2021.102642
56. [56]
  S. Chi, L. Zhang, H. Cheng, et al., Angew. Chem. Int. Ed. 62 (2023) e202304419. doi: 10.1002/anie.202304419
57. [57]
  K. Ahirwar, A. Kumar, N. Srivastava, S.A. Saraf, R. Shukla, Int. J. Biol. Macromol. 266 (2024) 131048. doi: 10.1016/j.ijbiomac.2024.131048
58. [58]
  A.S. Carlini, L. Adamiak, N.C. Gianneschi, Macromolecules 49 (2016) 4379–4394. doi: 10.1021/acs.macromol.6b00439
59. [59]
  A.O. Elzoghby, M.M. Abd-Elwakil, K. Abd-Elsalam, Curr. Pharm. Des. 22 (2016) 3305–3323. doi: 10.2174/1381612822666160204120829
60. [60]
  Y. Nie, L. Wang, S. Liu, et al., J. Nanobiotechnol. 21 (2023) 484. doi: 10.1186/s12951-023-02254-x
61. [61]
  E. Manek, F. Darvas, G.A. Petroianu, Molecules 25 (2020) 4866. doi: 10.3390/molecules25204866
62. [62]
  P. Agrawal, R.P.Singh Sonali, Colloids Surf. B: Biointerfaces 152 (2017) 277–288. doi: 10.1016/j.colsurfb.2017.01.021
63. [63]
  S. Di Gioia, G. Fracchiolla, S. Cometa, et al., Int. J. Biol. Macromol. 253 (2023) 127174. doi: 10.1016/j.ijbiomac.2023.127174
64. [64]
  A.E. Caprifico, P.J.S. Foot, E. Polycarpou, G. Calabrese, Pharmaceutics 12 (2020) 1013. doi: 10.3390/pharmaceutics12111013
65. [65]
  M.N. Savari, Sci. Rep. 14 (2024) 7000. doi: 10.1038/s41598-024-57565-2
66. [66]
  H. Hua, X. Zhang, H. Mu, et al., Int. J. Pharm. 543 (2018) 179–189. doi: 10.1016/j.ijpharm.2018.03.028
67. [67]
  M. Barrow, A. Taylor, D.J. Nieves, et al., Biomater. Sci. 3 (2015) 608–616. doi: 10.1039/C5BM00011D
68. [68]
  W. Zhang, X. Deng, L. Wang, et al., Chin. Chem. Lett. 35 (2024) 109422. doi: 10.1016/j.cclet.2023.109422
69. [69]
  R. Gobi, P. Ravichandiran, R.S. Babu, D.J. Yoo, Polymers 13 (2021) 1962. doi: 10.3390/polym13121962
70. [70]
  M. Tanaka, Chem. Pharm. Bull. 70 (2022) 507–513. doi: 10.1248/cpb.c22-00125
71. [71]
  R. Wang, L. Zou, Z. Yi, et al., Int. J. Pharm. 639 (2023) 122944. doi: 10.1016/j.ijpharm.2023.122944
72. [72]
  R. Mahar, A. Chakraborty, N. Nainwal, et al., AAPS PharmSciTech 24 (2023) 39. doi: 10.1208/s12249-023-02502-1
73. [73]
  B. Sharmah, A. Borthakur, P. Manna, Adv. Therap. 7 (2024) 2300424. doi: 10.1002/adtp.202300424
74. [74]
  L. Del Amo, A. Cano, M. Ettcheto, et al., Appl. Sci. 11 (2021) 4305. doi: 10.3390/app11094305
75. [75]
  M.J. Ramalho, I.D. Torres, J.A. Loureiro, J. Lima, M.C. Pereira, ACS Appl. Nano Mater. 6 (2023) 14191–14203. doi: 10.1021/acsanm.3c02122
76. [76]
  S. Kaya, B. Callan, S. Hawthorne, Pharmaceutics 15 (2023) 1382. doi: 10.3390/pharmaceutics15051382
77. [77]
  L. Zhou, H. Hu, H.L. Cong, et al., Integr. Ferroelectr. 199 (2019) 85–94. doi: 10.1080/10584587.2019.1592601
78. [78]
  M. Kaurav, S. Ruhi, H.A. Al-Goshae, et al., Front. Pharmacol. 14 (2023) 1159131. doi: 10.3389/fphar.2023.1159131
79. [79]
  H.H. de Oliveira Sobrinho, R. Eising, E.O. Wrasse, Mol. Syst. Des. Eng. 8 (2023) 1295–1300. doi: 10.1039/d3me00060e
80. [80]
  H. Cong, L. Zhou, Q. Meng, Biomater. Sci. 7 (2019) 3918–3925. doi: 10.1039/c9bm00960d
81. [81]
  G. Zhong, H. Long, T. Zhou, et al., Biomaterials 288 (2022) 121690. doi: 10.1016/j.biomaterials.2022.121690
82. [82]
  C. Song, Z. Ouyang, Y. Gao, Nano Today 41 (2021) 101325. doi: 10.1016/j.nantod.2021.101325
83. [83]
  K. Wiwatchaitawee, K. Ebeid, J.C. Quarterman, et al., Bioconjugate Chem. 33 (2022) 1957–1972. doi: 10.1021/acs.bioconjchem.1c00479
84. [84]
  Y. Wang, L. He, H. Cong, et al., Polymers 10 (2018) 1272. doi: 10.3390/polym10111272
85. [85]
  H. Yan, P. Xu, H. Cong, B. Yu, Y. Shen, Mater. Today Chem. 37 (2024) 101997. doi: 10.1016/j.mtchem.2024.101997
86. [86]
  X. Wang, M. Zhang, H. Cong, et al., Small 19 (2023) 2304006. doi: 10.1002/smll.202304006
87. [87]
  R. Tian, Z. Liu, Y. Chen, et al., Materials Express 13 (2023) 1138–1145. doi: 10.1166/mex.2023.2449
88. [88]
  D. Das, D. Narayanan, R. Ramachandran, et al., J. Control. Release 355 (2023) 474–488. doi: 10.1016/j.jconrel.2023.01.085
89. [89]
  R.K. Sahoo, H. Kumar, V. Jain, et al., ACS Biomater. Sci. Eng. 9 (2023) 4288–4301. doi: 10.1021/acsbiomaterials.3c00263
90. [90]
  Y. Fang, T. Nie, G. Li, et al., Chem. Eng. J. 480 (2024) 147930. doi: 10.1016/j.cej.2023.147930
91. [91]
  M. Zhou, Y. Wu, M. Sun, et al., J. Control. Release 365 (2024) 876–888. doi: 10.1016/j.jconrel.2023.11.046
92. [92]
  I. Hasan, S. Roy, E. Ehexige, et al., Nanoscale 15 (2023) 18108–18138. doi: 10.1039/d3nr04241c
93. [93]
  B. Feng, K. Tomizawa, H. Michiue, et al., Biomaterials 31 (2010) 4139–4145. doi: 10.1016/j.biomaterials.2010.01.086
94. [94]
  J. Cen, X. Dai, H. Zhao, et al., ACS Appl. Mater. Interfaces 15 (2023) 46697–46709. doi: 10.1021/acsami.3c10364
95. [95]
  N. Kato, S. Yamada, R. Suzuki, et al., Drug Deliv. Drug Deliv. 30 (2023) 2173333. doi: 10.1080/10717544.2023.2173333
96. [96]
  R. Jnaidi, A.J. Almeida, L.M. Gonçalves, Pharmaceutics 12 (2020) 860. doi: 10.3390/pharmaceutics12090860
97. [97]
  M.K. Satapathy, T.L. Yen, J.S. Jan, et al., Pharmaceutics 13 (2021) 1183. doi: 10.3390/pharmaceutics13081183
98. [98]
  M. Farshbaf, S. Mojarad-Jabali, S. Hemmati, et al., J. Control. Release 345 (2022) 371–384. doi: 10.1016/j.jconrel.2022.03.019
99. [99]
  N. Ouyang, C. Yang, X. Li, et al., Drug Deliv. Transl. Res. 14 (2024) 773–787. doi: 10.1007/s13346-023-01432-6
100. [100]
  D. Ran, J. Mao, C. Zhan, et al., ACS Appl. Mater. Interfaces 9 (2017) 25672–25682. doi: 10.1021/acsami.7b03518
101. [101]
  L. Lu, X. Zhao, T. Fu, et al., Biomaterials 230 (2020) 119666. doi: 10.1016/j.biomaterials.2019.119666
102. [102]
  V. Pokharkar, S. Suryawanshi, V. Dhapte-Pawar, Drug Deliv. Transl. Res. 10 (2020) 1019–1031. doi: 10.1007/s13346-019-00702-6
103. [103]
  N. Jirofti, M. Poorsargol, F. Sarhaddi, et al., Eur. Polym. J. 196 (2023) 112228. doi: 10.1016/j.eurpolymj.2023.112228
104. [104]
  D. Li, T. Ren, X. Wang, et al., Biomed. Pharmacother. 167 (2023) 115631. doi: 10.1016/j.biopha.2023.115631
105. [105]
  L. Fan, Y. Feng, J. Bian, et al., Chin. Chem. Lett. 35 (2024) 108443. doi: 10.1016/j.cclet.2023.108443
106. [106]
  A. Tomitaka, S. Ota, K. Nishimoto, et al., Nanoscale 11 (2019) 6489–6496. doi: 10.1039/c9nr00242a
107. [107]
  X. Liu, Z. Guo, J. Li, Bio-Medical Mater. Eng. 35 (2024) 279–292. doi: 10.3233/bme-230171
108. [108]
  S.F. Lai, B.H. Ko, C.C. Chien, et al., J. Nanobiotechnol. 13 (2015) 85. doi: 10.1186/s12951-015-0140-2
109. [109]
  L. Zhao, Y. Li, J. Zhu, et al., J. Nanobiotechnol. 17 (2019) 30. doi: 10.1109/mnet.2019.1800221
110. [110]
  H.S. Kim, M. Seo, T.E. Park, D.Y. Lee, J. Nanobiotechnol. 20 (2022) 14. doi: 10.1186/s12951-021-01220-9
111. [111]
  S. Ohta, E. Kikuchi, A. Ishijima, et al., Sci. Rep. 10 (2020) 18220. doi: 10.1038/s41598-020-75253-9
112. [112]
  H. Fei, Y. Jin, N. Jiang, et al., Biomaterials 306 (2024) 122479. doi: 10.1016/j.biomaterials.2024.122479
113. [113]
  M.S. Attia, A. Yahya, N.A. Monaem, S.A. Sabry, Saudi Pharm. J. 31 (2023) 417–432. doi: 10.1016/j.jsps.2023.01.009
114. [114]
  Y.P. Chen, C.M. Chou, T.Y. Chang, et al., Front. Chem. 10 (2022) 931584. doi: 10.3389/fchem.2022.931584
115. [115]
  T.C. Ribeiro, R.M. Sábio, G.C. Carvalho, B. Fonseca-Santos, M. Chorilli, Int. J. Pharm. 624 (2022) 121978. doi: 10.1016/j.ijpharm.2022.121978
116. [116]
  P. Zhang, F. Cao, J. Zhang, Y. Tan, S. Yao, Heliyon 9 (2023) e18490.
117. [117]
  Y. Liu, S. Yu, X. Jiang, et al., Mater. Des. 238 (2024) 112715. doi: 10.1016/j.matdes.2024.112715
118. [118]
  H. Wei, X. Li, F. Huang, et al., Chin. Chem. Lett. 34 (2023) 108564. doi: 10.1016/j.cclet.2023.108564
119. [119]
  L. Ribovski, E. de Jong, O. Mergel, et al., Nanomed. Nanotech. Biol. Med. 34 (2021) 102377. doi: 10.1016/j.nano.2021.102377
120. [120]
  X. Zhang, W. Yan, Z. Song, et al., Adv. Therap. 6 (2023) 2200287. doi: 10.1002/adtp.202200287
121. [121]
  D. Suzuki, Langmuir 39 (2023) 7525–7529. doi: 10.1021/acs.langmuir.3c00560
122. [122]
  S. Singh, N. Drude, L. Blank, et al., Adv. Healthcare Mater. 10 (2021) 2100812. doi: 10.1002/adhm.202100812
123. [123]
  Q. Li, J. Shen, L. Wu, et al., Cancer Nanotechnol 14 (2023) 12. doi: 10.1186/s12645-023-00167-w
124. [124]
  A. Mushtaq, S. Mohd Wani, A.R. Malik, et al., Food Chem. X 18 (2023) 100684. doi: 10.1016/j.fochx.2023.100684
125. [125]
  B. Alhasso, M.U. Ghori, B.R. Conway, Pharmaceutics 15 (2023) 378. doi: 10.3390/pharmaceutics15020378
126. [126]
  M.C. Bonferoni, S. Rossi, G. Sandri, Pharmaceutics 11 (2019) 84. doi: 10.3390/pharmaceutics11020084
127. [127]
  Z. Zhao, B.V. Zlokovic, Cell Res 27 (2017) 849–850. doi: 10.1038/cr.2017.71
128. [128]
  Y. Zhou, L. Wang, L. Chen, et al., Nano Res 16 (2023) 13283–13293. doi: 10.1007/s12274-023-5921-6
129. [129]
  M. Heidarzadeh, Y. Gürsoy-Özdemir, M. Kaya, et al., Cell Biosci 11 (2021) 142. doi: 10.1186/s13578-021-00650-0
130. [130]
  P. Jiang, Y. Xiao, X. Hu, et al., ACS Biomater. Sci. Eng. 10 (2024) 3069–3085. doi: 10.1021/acsbiomaterials.3c01622
131. [131]
  Y. Wang, Y. Huo, C. Zhao, et al., J. Control. Release 368 (2024) 170–183. doi: 10.3390/cryst14020170
132. [132]
  C. Lu, G. Chen, B. Yu, H. Cong, Adv. Eng. Mater. 20 (2018) 1700940. doi: 10.1002/adem.201700940
133. [133]
  F. Liu, B. Huang, T. Tang, et al., Chem. Eng. J. 471 (2023) 144697. doi: 10.1016/j.cej.2023.144697
134. [134]
  P.A. Aaron, A. Gelli, ACS Infect. Dis. 6 (2020) 138–149. doi: 10.1021/acsinfecdis.9b00348
135. [135]
  G. Perini, V. Palmieri, G. Ciasca, M. De Spirito, M. Papi, Int. J. Mol. Sci. 21 (2020) 3712. doi: 10.3390/ijms21103712
136. [136]
  D. Huang, Q. Wang, Y. Cao, et al., ACS Nano 17 (2023) 5033–5046. doi: 10.1021/acsnano.2c12840
137. [137]
  D. Lin, M. Li, Y. Gao, L. Yin, Y. Guan, Chem. Eng. J. 429 (2022) 132210. doi: 10.1016/j.cej.2021.132210
138. [138]
  Y. Zhu, S. Cao, M. Huo, et al., Chem. Sci. 14 (2023) 7411–7437. doi: 10.1039/d3sc01707a
139. [139]
  R.A.J.F. Oerlemans, J. Shao, S.G.A.M. Huisman, et al., Macromol. Rapid Commun. 44 (2023) 2200904. doi: 10.1002/marc.202200904
140. [140]
  M. Sánchez-Purrà, V. Ramos, V.A. Petrenko, V.P. Torchilin, S. Borrós, Int. J. Pharm. 511 (2016) 946–956. doi: 10.1016/j.ijpharm.2016.08.001
141. [141]
  W.M. Pardridge, Front. Aging Neurosci. 15 (2023) 1276376. doi: 10.3389/fnagi.2023.1276376
142. [142]
  Y. Zhu, Y. Yang, J. Guo, et al., BioMed Res. Int. 2017 (2017) 1492327.
143. [143]
  W.M. Pardridge, Front. Physiol. 11 (2020) 398. doi: 10.3389/fphys.2020.00398
144. [144]
  R.J. Boado, Pharmaceutics 14 (2022) 1476. doi: 10.3390/pharmaceutics14071476
145. [145]
  J. Li, Z. Zhang, B. Zhang, X. Yan, K. Fan, Biomater. Sci. 11 (2023) 3394–3413. doi: 10.1039/d2bm02152h
146. [146]
  S. Li, Z. Peng, J. Dallman, et al., Colloids Surf. B: Biointerfaces 145 (2016) 251–256. doi: 10.1016/j.colsurfb.2016.05.007
147. [147]
  S.M. Ashrafzadeh, A. Heydarinasab, A. Akbarzadeh, M. Ardjmand, Lett. Drug Des. Discov. 17 (2020) 1126–1138. doi: 10.2174/1570180817999200330165213
148. [148]
  S. Kang, W. Duan, S. Zhang, et al., Theranostics 10 (2020) 4308–4322. doi: 10.7150/thno.41322
149. [149]
  A. Dasgupta, T. Sun, E. Rama, et al., Adv. Mater. 35 (2023) 2308150. doi: 10.1002/adma.202308150
150. [150]
  J.H. Lee, J.A. Engler, J.F. Collawn, B.A. Moore, Eur. J. Biochem. 268 (2001) 2004–2012. doi: 10.1046/j.1432-1327.2001.02073.x
151. [151]
  X. Fang, Z. Chen, W. Zhou, et al., Small 19 (2023) 2207604. doi: 10.1002/smll.202207604
152. [152]
  M.M. Agwa, S. Sabra, Int. J. Biol. Macromol. 167 (2021) 1527–1543. doi: 10.1016/j.ijbiomac.2020.11.107
153. [153]
  H.S. Kim, S.C. Park, H.J. Kim, D.Y. Lee, Biomater. Res. 27 (2023) 52. doi: 10.1186/s40824-023-00391-w
154. [154]
  H. Chen, Y. Qin, Q. Zhang, et al., Eur. J. Pharm. Sci. 44 (2011) 164–173. doi: 10.1016/j.ejps.2011.07.007
155. [155]
  H. Li, Y. Tong, L. Bai, et al., Int. J. Biol. Macromol. 107 (2018) 204–211. doi: 10.1016/j.ijbiomac.2017.08.155
156. [156]
  M. Li, K. Shi, X. Tang, et al., Nanomed. Nanotech. Biol. Med. 14 (2018) 1833–1843.
157. [157]
  C.K. Elechalawar, D. Bhattacharya, M.T. Ahmed, et al., Nanomed. Nanotech. Biol. Med. 1 (2019) 3555–3567. doi: 10.1039/c9na00056a
158. [158]
  H.M. Liu, Y. Zhang, Kaohsiung J. Med. Sci. 40 (2024) 435–444. doi: 10.1002/kjm2.12819
159. [159]
  K. Ulbrich, T. Hekmatara, E. Herbert, J. Kreuter, Eur. J. Pharm. Biopharm. 71 (2009) 251–256. doi: 10.1016/j.ejpb.2008.08.021
160. [160]
  D. Zhang, J. Kong, X. Huang, et al., Mater. Today Nano 23 (2023) 100347. doi: 10.1016/j.mtnano.2023.100347
161. [161]
  I. Kimura, S. Dohgu, F. Takata, et al., Neurosci. Lett. 694 (2019) 9–13. doi: 10.1016/j.neulet.2018.11.022
162. [162]
  F. Ji, L. Xu, K. Long, et al., Transl. Res. 259 (2023) 1–12. doi: 10.1016/j.trsl.2023.03.003
163. [163]
  Y. Molino, M. David, K. Varini, et al., FASEB J. 31 (2017) 1807–1827. doi: 10.1096/fj.201600827R
164. [164]
  Z. Ye, T. Zhang, W. He, et al., ACS Appl. Mater. Interfaces 10 (2018) 12341–12350. doi: 10.1021/acsami.7b18135
165. [165]
  G. Bor, L. Hosta-Rigau, Adv. Ther. 6 (2023) 2300161. doi: 10.1002/adtp.202300161
166. [166]
  D.Ý. Þorgeirsdóttir, J.H. Andersen, M. Perch-Nielsen, et al., Eur. J. Pharm. Sci. 183 (2023) 106400. doi: 10.1016/j.ejps.2023.106400
167. [167]
  E. Melander, C. Eriksson, S. Wellens, et al., Pharmaceutics 15 (2023) 1507. doi: 10.3390/pharmaceutics15051507
168. [168]
  R. Blades, L.M. Ittner, O. Tietz, J. Label. Comp. Radiopharm. 66 (2023) 237–248. doi: 10.1002/jlcr.4023
169. [169]
  N. Shadmani, P. Makvandi, M. Parsa, et al., Mol. Pharm. 20 (2023) 1531–1548. doi: 10.1021/acs.molpharmaceut.2c00755
170. [170]
  T. Saha, A.A. van Vliet, C. Cui, et al., Front. Mol. Biosci. 8 (2021) 754443. doi: 10.3389/fmolb.2021.754443
171. [171]
  J.H. Lim, M. Park, Y. Park, et al., Molecules 28 (2023) 3223. doi: 10.3390/molecules28073223
172. [172]
  D. Sagar, N.P. Singh, R. Ginwala, Sci. Rep. 7 (2017) 2707. doi: 10.1038/s41598-017-03027-x
173. [173]
  A.M. Hersh, S. Alomari, B.M. Tyler, Int. J. Mol. Sci. 23 (2022) 4153. doi: 10.3390/ijms23084153
174. [174]
  R. Jomura, S.I. Akanuma, B. Bauer, et al., Pharm. Res. 38 (2021) 113–125. doi: 10.1007/s11095-021-03003-1
175. [175]
  Y. Zhang, Y. Ren, H. Xu, L. Li, et al., ACS Appl. Mater. Interfaces 15 (2023) 10356–10370. doi: 10.1021/acsami.2c19285
176. [176]
  M. Iv, N. Telischak, D. Feng, et al., Nanomedicine 10 (2015) 993–1018. doi: 10.2217/nnm.14.203
177. [177]
  J. Xie, Z. Shen, Y. Anraku, K. Kataoka, X. Chen, Biomaterials 224 (2019) 119491. doi: 10.1016/j.biomaterials.2019.119491
178. [178]
  V.H. Tam, C. Sosa, R. Liu, N. Yao, R.D. Priestley, Int. J. Pharm. 515 (2016) 331–342. doi: 10.1016/j.ijpharm.2016.10.031
179. [179]
  W.M. Pardridge, Pharmaceutics 14 (2022) 1283. doi: 10.3390/pharmaceutics14061283
180. [180]
  M. Kannan, S. Sil, A. Oladapo, Redox Biol. 62 (2023) 102689. doi: 10.1016/j.redox.2023.102689
181. [181]
  K. Li, Y. Wang, Y. Xu, et al., Chin. Chem. Lett. 35 (2024) 109511. doi: 10.1016/j.cclet.2024.109511
1. [1]
  Liqing Chen , Zheming Zhang , Yanhong Liu , Chenfei Liu , Congcong Xiao , Liming Gong , Mingji Jin , Zhonggao Gao , Wei Huang . Systemically intravenous siRNA delivery into brain with a targeting and efficient polypeptide carrier and its evaluation on anti-glioma efficacy. Chinese Chemical Letters, 2025, 36(3): 110228-. doi: 10.1016/j.cclet.2024.110228
2. [2]
  Lei Shen , Hongmei Liu , Ming Jin , Jinchao Zhang , Caixia Yin , Shuxiang Wang , Yutao Yang . “Three-in-one” strategy of trifluoromethyl regulated blood-brain barrier permeable fluorescent probe for peroxynitrite and antiepileptic evaluation of edaravone. Chinese Chemical Letters, 2024, 35(10): 109572-. doi: 10.1016/j.cclet.2024.109572
3. [3]
  Yinglan Yu , Sajid Hussain , Jianping Qi , Lei Luo , Xuemei Zhang . Mechanisms and applications: Cargos transport to basolateral membranes in polarized epithelial cells. Chinese Chemical Letters, 2024, 35(12): 109673-. doi: 10.1016/j.cclet.2024.109673
4. [4]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
5. [5]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
6. [6]
  Xingqun Pu , Rongrong Liu , Yuting Xie , Chenjing Yang , Jingyi Chen , Baoling Guo , Chun-Xia Zhao , Peng Zhao , Jian Ruan , Fangfu Ye , David A Weitz , Dong Chen . One-step preparation of biocompatible amphiphilic dimer nanoparticles with tunable particle morphology and surface property for interface stabilization and drug delivery. Chinese Chemical Letters, 2025, 36(3): 109820-. doi: 10.1016/j.cclet.2024.109820
7. [7]
  Makhloufi Zoulikha , Zhongjian Chen , Jun Wu , Wei He . Approved delivery strategies for biopharmaceuticals. Chinese Chemical Letters, 2025, 36(2): 110225-. doi: 10.1016/j.cclet.2024.110225
8. [8]
  Jing Zhang , Charles Wang , Yaoyao Zhang , Haining Xia , Yujuan Wang , Kun Ma , Junfeng Wang . Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine. Chinese Chemical Letters, 2024, 35(10): 109420-. doi: 10.1016/j.cclet.2023.109420
9. [9]
  Tong Tong , Lezong Chen , Siying Wu , Zhong Cao , Yuanbin Song , Jun Wu . Establishment of a leucine-based poly(ester amide)s library with self-anticancer effect as nano-drug carrier for colorectal cancer treatment. Chinese Chemical Letters, 2024, 35(12): 109689-. doi: 10.1016/j.cclet.2024.109689
10. [10]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254
11. [11]
  Xueyan Zhang , Jicong Chen , Songren Han , Shiyan Dong , Huan Zhang , Yuhong Man , Jie Yang , Ye Bi , Lesheng Teng . The size-switchable microspheres co-loaded with RANK siRNA and salmon calcitonin for osteoporosis therapy. Chinese Chemical Letters, 2024, 35(12): 109668-. doi: 10.1016/j.cclet.2024.109668
12. [12]
  Lihang Wang , Mary Li Javier , Chunshan Luo , Tingsheng Lu , Shudan Yao , Bing Qiu , Yun Wang , Yunfeng Lin . Research advances of tetrahedral framework nucleic acid-based systems in biomedicine. Chinese Chemical Letters, 2024, 35(11): 109591-. doi: 10.1016/j.cclet.2024.109591
13. [13]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
14. [14]
  Wen Xiao , Fazhan Wang , Yangzhuo Gu , Xi He , Na Fan , Qian Zheng , Shugang Qin , Zhongshan He , Yuquan Wei , Xiangrong Song . PEG400-mediated nanocarriers improve the delivery and therapeutic efficiency of mRNA tumor vaccines. Chinese Chemical Letters, 2024, 35(5): 108755-. doi: 10.1016/j.cclet.2023.108755
15. [15]
  Yong-Dan Zhao , Yidan Wang , Rongrong Wang , Lina Chen , Hengtong Zuo , Xi Wang , Jihong Qiang , Geng Wang , Qingxia Li , Canqi Ping , Shuqiu Zhang , Hao Wang . Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH. Chinese Chemical Letters, 2024, 35(6): 108929-. doi: 10.1016/j.cclet.2023.108929
16. [16]
  Keyang Li , Yanan Wang , Yatao Xu , Guohua Shi , Sixian Wei , Xue Zhang , Baomei Zhang , Qiang Jia , Huanhua Xu , Liangmin Yu , Jun Wu , Zhiyu He . Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation. Chinese Chemical Letters, 2024, 35(10): 109511-. doi: 10.1016/j.cclet.2024.109511
17. [17]
  Yuanzheng Wang , Chen Zhang , Shuyan Han , Xiaoli Kong , Changyun Quan , Jun Wu , Wei Zhang . Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition. Chinese Chemical Letters, 2024, 35(11): 109578-. doi: 10.1016/j.cclet.2024.109578
18. [18]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
19. [19]
  Wenjun Yang , Qiaoling Tan , Wenjiao Xie , Xiaoyu Pan , Youyong Yuan . Construction and Characterization of Calcium Alginate Microparticle Drug Delivery System: A Novel Design and Teaching Practice in Polymer Experiments. University Chemistry, 2025, 40(3): 371-380. doi: 10.12461/PKU.DXHX202405150
20. [20]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(80)
HTML views(4)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142