Citation: Ziqin Li, Kai Hao, Longwei Xiang, Huayu Tian. Cationic covalent organic framework nanocarriers integrating both efficient gene silencing and real-time gene detection[J]. Chinese Chemical Letters, ;2025, 36(4): 109943. doi: 10.1016/j.cclet.2024.109943 shu

Cationic covalent organic framework nanocarriers integrating both efficient gene silencing and real-time gene detection

Ziqin Li ^a ,
Kai Hao ^a ,
Longwei Xiang ^a ,
Huayu Tian ^{a, b, c, *,}

a.
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
b.
Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen 361005, China
c.
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

thy@xmu.edu.cn

Received Date: 12 March 2024
Revised Date: 24 April 2024
Accepted Date: 28 April 2024
Available Online: 29 April 2024

Figures(5)

The occurrence, development, and metastasis of tumors often entail abnormal expression of genetic substances. Monitoring and regulating changes in intracellular nucleic acid substances hold promise for achieving accurate tumor diagnosis and effective treatment. However, the effectiveness of integrated tumor diagnosis and treatment based on functional nucleic acids still needs to be improved. In this study, we engineered a multifunctional nucleic acid delivery system grounded in a cationic covalent organic framework carrier. This system not only showcases effective gene silencing but also boasts high sensitivity in detecting miR21 levels within tumor cells, enabling real-time monitoring of tumor gene therapy efficacy. The construction of this integrated functional nucleic acid delivery platform provides new ideas for precise tumor detection and effective tumor treatment.
- Tumor diagnosis,
- Cancer therapy,
- Nucleic acid delivery,
- Cationic COF,
- Gene silencing
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沈阳化工大学材料科学与工程学院沈阳 110142