Citation: Qi Huang, Jun Liao, Jingjing Li, Zhengyan Gu, Xinkang Zhang, Mingxue Sun, Wenqi Meng, Guanchao Mao, Zhipeng Pei, Shanshan Zhang, Songling Li, Chuan Zhang, Yunqin Wang, Jihao Liu, Tingbin Shu, Min Tao, Ying Lu, Kai Xiao, Qingqiang Xu, Jincai Lu. Curcumin-loaded ceria nanoenzymes for dual-action suppression of inflammation and alleviation of oxidative damage in the treatment of acute lung injury[J]. Chinese Chemical Letters, ;2025, 36(4): 109914. doi: 10.1016/j.cclet.2024.109914 shu

Curcumin-loaded ceria nanoenzymes for dual-action suppression of inflammation and alleviation of oxidative damage in the treatment of acute lung injury

Qi Huang ^{a, b, 1} ,
Jun Liao ^{c, d, e, 1} ,
Jingjing Li ^{a, b, 1} ,
Zhengyan Gu ^{b, d, 1} ,
Xinkang Zhang ^b ,
Mingxue Sun ^b ,
Wenqi Meng ^b ,
Guanchao Mao ^b ,
Zhipeng Pei ^b ,
Shanshan Zhang ^b ,
Songling Li ^b ,
Chuan Zhang ^e ,
Yunqin Wang ^b ,
Jihao Liu ^b ,
Tingbin Shu ^b ,
Min Tao ^b ,
Ying Lu ^{d, *,} ,
Kai Xiao ^{b, f, *,} ,
Qingqiang Xu ^{b, g, *,} ,
Jincai Lu ^{a, *,}

a.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
b.
Lab of Toxicology and Pharmacology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China
c.
School of Basic Medical Sciences, Peking University, Beijing 100191, China
d.
Department of Pharmaceutical Sciences, School of Pharmacy, Naval Medical University, Shanghai 200433, China
e.
School of Medicine, Shanghai University, Shanghai 200444, China
f.
Marine Biomedical Science and Technology Innovation Platform of Lingang Special Area, Shanghai 201306, China
g.
Basic Medical Center for Pulmonary Disease, Naval Medical University, Shanghai 200433, China

acuace@163.com

kaixiaocn@163.com

xuqingqiang1027@126.com

jincailu@syphu.edu.cn

Received Date: 26 February 2024
Revised Date: 15 April 2024
Accepted Date: 21 April 2024
Available Online: 22 April 2024

Figures(4)

Acute lung injury (ALI) is a critical respiratory disorder with a high mortality rate and is caused by several factors. Addressing oxidative stress and inflammation is a pivotal strategy for ALI treatment. In this study, we introduced a novel nanotherapeutic approach involving a curcumin-loaded ceria nanoenzyme delivery system tailored to counteract the multifaceted aspects of ALI. This system leverages the individual and combined effects of the components to provide a comprehensive therapeutic solution. The dual-action capability of this nanosystem was manifested by mitigating mitochondrial oxidative stress in lung epithelial cells and inhibiting the transient receptor potential melanosome-associated protein 2 (TRPM2)-NOD-like receptor thermal protein domain associated protein 3 (NLRP3) signaling pathway, offering a highly effective therapeutic approach to ALI. Our findings reveal the underlying mechanisms of this innovative nanodelivery system, showcasing its potential as a versatile strategy for ALI treatment and encouraging further exploration of nanoenzyme-based therapies for ALI.
- Ceria nanoenzymes,
- Curcumin,
- Acute lung injury,
- Oxidative damage,
- Inflammation,
- Nano delivery systems
1. [1]
  S.R. Leist, K.H. Dinnon, A. Schäfer, et al., Cell 183 (2020) 1070–1085.
2. [2]
  W. Zhong, X. Zhang, Y. Zeng, et al., Nano Res. 14 (2021) 2067–2089. doi: 10.1007/s12274-020-3180-3
3. [3]
  Y. Wang, Q. Li, M. Deng, et al., Chin. Chem. Lett. 33 (2022) 324–327. doi: 10.1016/j.cclet.2021.06.080
4. [4]
  H. Wu, F. Li, S. Wang, et al., Biomaterials 151 (2018) 66–77. doi: 10.1002/sam.11370
5. [5]
  C. Zhuang, M. Kang, M. Lee, J. Control. Release 360 (2023) 1–14.
6. [6]
  Y. Li, J. Liao, L. Xiong, et al., J. Control. Release 368 (2024) 607–622.
7. [7]
  C. Liu, J. Yao, J. Hu, et al., Mater. Horiz. 7 (2020) 3176–3186. doi: 10.1039/d0mh01225d
8. [8]
  Y. Meng, S. Han, J. Yin, J. Wu, ACS Appl. Mater. Interfaces 15 (2023) 41743–41754. doi: 10.1021/acsami.3c08608
9. [9]
  C. Liu, W. Fan, W.X. Cheng, et al., Adv. Funct. Mater. 33 (2023) 2213856.
10. [10]
  J. Liao, Y. Li, L. Fan, et al., ACS Nano 18 (2024) 5510–5529.
11. [11]
  C. Liu, J. Xing, O.U. Akakuru, et al., Nano Lett. 19 (2019) 5674–5682. doi: 10.1021/acs.nanolett.9b02253
12. [12]
  C. Liu, L. Luo, L. Zeng, et al., Small 14 (2018) 1801851.
13. [13]
  J. Liu, D. He, T. Hao, et al., Chin. Chem. Lett. 35 (2024) 109296. doi: 10.1016/j.cclet.2023.109296
14. [14]
  Z. Wu, H. Wang, S. Fang, C. Xu, Mol. Med. Rep. 18 (2018) 4163–4174.
15. [15]
  Y. Wang, H. Dong, H. Qu, et al., Nano Lett. 24 (2024) 2131–2141. doi: 10.1021/acs.nanolett.3c03671
16. [16]
  F. Zeng, Y. Wu, X. Li, et al., Angew. Chem. Int. Ed. 57 (2018) 5808–5812. doi: 10.1002/anie.201802309
17. [17]
  J. Liao, Y. Li, Y. Luo, et al., Mol. Pharm. 19 (2022) 3026–3041. doi: 10.1021/acs.molpharmaceut.2c00383
18. [18]
  J. Liao, L. Fan, Y. Li, et al., J. Control. Release 358 (2023) 439–464.
19. [19]
  C. Xie, J. Liao, N. Zhang, et al., Chin. Chem. Lett. 35 (2024) 109149. doi: 10.1016/j.cclet.2023.109149
20. [20]
  R. Yuan, Y. Li, S. Han, et al., ACS Cent. Sci. 8 (2021) 10–21. doi: 10.15302/j-laf-1-010013
21. [21]
  H. He, L. Du, H. Xue, et al., Small Methods 7 (2023) 2300230.
22. [22]
  L. Sun, Y. Liu, X. Liu, et al., Adv. Sci. 9 (2022) 2104051.
23. [23]
  C. Liu, L. Xi, Y. Liu, et al., ACS Nano 17 (2023) 11626–11644. doi: 10.1021/acsnano.3c02075
24. [24]
  A. Unlu, E. Nayir, M. Dogukan Kalenderoglu, et al., J. BUON 21 (2016) 1050–1060.
25. [25]
  J. Gao, Z. Weng, Z. Zhang, et al., Adv. Healthc. Mater. 13 (2024) 2303095. doi: 10.1002/adhm.202303095
26. [26]
  A. Farazin, M. Mohammadimehr, A.H. Ghasemi, H. Naeimi, RSC Adv. 11 (2021) 32775–32791.
27. [27]
  H. Wei, D. Jiang, B. Yu, et al., Bioact. Mater. 19 (2023) 282–291.
28. [28]
  N.J. Himmel, D.N. Cox, Proc. Biol. Soc. 287 (2020) 20201309.
29. [29]
  E. Jäger, S. Murthy, C. Schmidt, et al., Nat. Commun. 11 (2020) 4243.
30. [30]
  K. Wang, Q. Sun, X. Zhong, et al., Cell 180 (2020) 941–955.
31. [31]
  L. Meng, X. Zhao, H. Zhang, Med. Sci. Monit. 25 (2019) 827–835. doi: 10.12659/msm.912507
32. [32]
  F.J. Bock, S.W.G. Tait, Nat. Rev. Mol. Cell Biol. 21 (2020) 85–100. doi: 10.1038/s41580-019-0173-8
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2. [2]
  Xiaoshuai Wu , Bailei Wang , Yichen Li , Xiaoxuan Guan , Mingjing Yin , Wenquan Lv , Yin Chen , Fei Lu , Tao Qin , Huyang Gao , Weiqian Jin , Yifu Huang , Cuiping Li , Ming Gao , Junyu Lu . NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS. Chinese Chemical Letters, 2025, 36(2): 110211-. doi: 10.1016/j.cclet.2024.110211
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9. [9]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
10. [10]
  Xing Tian , Di Wu , Wanheng Wei , Guifu Dai , Zhanxian Li , Benhua Wang , Mingming Yu . A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death, inflammation and fatty liver tissue. Chinese Chemical Letters, 2024, 35(6): 108912-. doi: 10.1016/j.cclet.2023.108912
11. [11]
  Yu Yan , Jiawei Song , Dongdong Liu , Zihan Liu , Jialing Cheng , Zhiyang Chen , Yanfang Yang , Weizhe Jiang , Hongliang Wang , Jun Ye , Yuling Liu . Simple and versatile in situ thermo-sensitive hydrogel for rectal administration of SZ-A to alleviate inflammation and repair mucosal barrier in ulcerative colitis. Chinese Chemical Letters, 2024, 35(6): 109736-. doi: 10.1016/j.cclet.2024.109736
12. [12]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
13. [13]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
14. [14]
  Jiechen Liu , Xiaoguang Li , Ruiyang Xia , Yuqi Wang , Fenghe Zhang , Yongzhi Pang , Qing Li . Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109619-. doi: 10.1016/j.cclet.2024.109619
15. [15]
  Qijun Tang , Wenguang Tu , Yong Zhou , Zhigang Zou . High efficiency and selectivity catalyst for photocatalytic oxidative coupling of methane. Chinese Journal of Structural Chemistry, 2023, 42(12): 100170-100170. doi: 10.1016/j.cjsc.2023.100170
16. [16]
  Jindian Duan , Xiaojuan Ding , Pui Ying Choy , Binyan Xu , Luchao Li , Hong Qin , Zheng Fang , Fuk Yee Kwong , Kai Guo . Oxidative spirolactonisation for modular access of γ-spirolactones via a radical tandem annulation pathway. Chinese Chemical Letters, 2024, 35(10): 109565-. doi: 10.1016/j.cclet.2024.109565
17. [17]
  Makhloufi Zoulikha , Zhongjian Chen , Jun Wu , Wei He . Approved delivery strategies for biopharmaceuticals. Chinese Chemical Letters, 2025, 36(2): 110225-. doi: 10.1016/j.cclet.2024.110225
18. [18]
  Yaping Zhang , Wei Zhou , Mingchun Gao , Tianqi Liu , Bingxin Liu , Chang-Hua Ding , Bin Xu . Oxidative cyclization of allyl compounds and isocyanide: A facile entry to polysubstituted 2-cyanopyrroles. Chinese Chemical Letters, 2024, 35(4): 108836-. doi: 10.1016/j.cclet.2023.108836
19. [19]
  Chuyu Huang , Zhishan Liu , Linping Zhao , Zuxiao Chen , Rongrong Zheng , Xiaona Rao , Yuxuan Wei , Xin Chen , Shiying Li . Metal-coordinated oxidative stress amplifier to suppress tumor growth combined with M2 macrophage elimination. Chinese Chemical Letters, 2024, 35(12): 109696-. doi: 10.1016/j.cclet.2024.109696
20. [20]
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