Citation: Du Liu, Yuyan Li, Hankun Zhang, Benhua Wang, Chaoyi Yao, Minhuan Lan, Zhanhong Yang, Xiangzhi Song. Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy[J]. Chinese Chemical Letters, ;2025, 36(2): 109910. doi: 10.1016/j.cclet.2024.109910 shu

Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy

College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, China

benhuawang@csu.edu.cn

chaoyiyao@csu.edu.cn

xzsong@csu.edu.cn

Received Date: 29 February 2024
Revised Date: 16 April 2024
Accepted Date: 18 April 2024
Available Online: 21 April 2024

Figures(5)

Photodynamic therapy (PDT) presents a promising avenue in cancer treatment. Erlotinib, an FDA-approved anticancer drug targeting epidermal growth factor receptor (EGFR), has shown effectiveness in normalizing tumor vasculature across various tumors, thereby promoting tumor oxygenation and facilitating PDT. In this work, erlotinib was conjugated with a near-infrared (NIR) photosensitizer, benzo[a]phenoselenazinium, yielding three EGFR-targeted PDT agents (NBSe-nC-Er). These newly synthesized photosensitizers demonstrate specificity in binding to EGFR, thereby enhancing their accumulation in cancer cells and tumors, and consequently improving the efficiency of both PDT and chemotherapy. Additionally, the NIR fluorescence emitted by the photosensitizer allows for imaging-guided therapy, offering a non-invasive means of monitoring treatment progress. The distinctive properties of the three-in-one photosensitizer render it an ideal candidate for precise tumor treatment, overcoming the limitations of conventional therapies.
- Photosensitizer,
- Benzo[a]phenoselenazinium,
- Fluorescence imaging,
- Photodynamic therapy,
- Chemotherapy
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沈阳化工大学材料科学与工程学院沈阳 110142