Citation: Pengyu Chen, Beibei Chen, Man He, Yuxi Zhou, Lei Lei, Jian Han, Bingsheng Zhou, Ligang Hu, Bin Hu. Nanoplastics and nano-ZnO facilitate Cd accumulation in zebrafish larvae via a distinct pathway: Revelation by LA-ICP-MS imaging[J]. Chinese Chemical Letters, ;2025, 36(2): 109908. doi: 10.1016/j.cclet.2024.109908 shu

Nanoplastics and nano-ZnO facilitate Cd accumulation in zebrafish larvae via a distinct pathway: Revelation by LA-ICP-MS imaging

Pengyu Chen ^a ,
Beibei Chen ^a ,
Man He ^a ,
Yuxi Zhou ^b ,
Lei Lei ^b ,
Jian Han ^b ,
Bingsheng Zhou ^b ,
Ligang Hu ^c ,
Bin Hu ^{a, *,}

a.
Department of Chemistry, Wuhan University, Wuhan 430072, China
b.
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
c.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China

binhu@whu.edu.cn

Received Date: 28 December 2023
Revised Date: 11 April 2024
Accepted Date: 17 April 2024
Available Online: 18 April 2024

Figures(5)

The interaction between nanoparticles (NPs) and pollutants affects their bioavailability and toxicity. However, the processes by which NPs and pollutants change in vivo have rarely been explored. Here, using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP–MS), we found that both nanoplastics and ZnO NPs caused more Cd to accumulate in zebrafish larvae, but with distinct pathways. Nanoplastics could adsorb Cd²⁺ and transfer it into the larvae through the "Trojan horse" effect. The coexposure of nanoplastics and Cd²⁺ caused Cd to accumulate in the abdomen where the nanoplastics were located without dissociation, showing a lower toxic effect than Cd²⁺ exposure alone. ZnO NPs weakly adsorbed Cd²⁺, but they increased the Zn and Cd contents in larvae by enhancing the expression of metal transporters. The coexposure of ZnO and Cd²⁺ evenly distributed Cd in the larvae, revealing a more severe toxic effect than Cd²⁺ exposure alone. Our results demonstrated the changing bioavailability and toxicity of Cd induced by different NPs. This also shows the vital role LA-ICP-MS plays in revealing the relationship between toxicity and bioavailability. In addition, the long-term effect of bioavailability on heavy metal toxicity and nanosafety deserves further investigation.
- LA-ICP-MS,
- Nanoplastics,
- ZnO nanoparticles,
- Cadmium,
- Combined effect,
- Zebrafish larvae
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