Citation: Yanwei Duan, Qing Yang. Molecular targets and their application examples for interrupting chitin biosynthesis[J]. Chinese Chemical Letters, ;2025, 36(4): 109905. doi: 10.1016/j.cclet.2024.109905 shu

Molecular targets and their application examples for interrupting chitin biosynthesis

Yanwei Duan ^{a, b} ,
Qing Yang ^{a, b, *,}

a.
Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China
b.
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China

qingyang@caas.cn

Received Date: 20 January 2024
Revised Date: 12 April 2024
Accepted Date: 16 April 2024
Available Online: 23 April 2024

Figures(5)

Chitin is an abundant aminopolysaccharide found in insect pests and phytopathogenic microorganisms but absent in higher plants and vertebrates. It is crucial for mitigating threats posed by chitin-containing organisms to human health, food safety, and agriculture. Therefore, targeting the chitin biosynthesis-associated bioprocess holds a promise for developing human-safe and eco-friendly antifungal agents or pesticides. Chitin biosynthesis requires chitin synthase and associated factors, which are involved in the modification, regulation, organization or turnover of chitin during its biosynthesis. A number of enzymes such as chitinases, hexosaminidases, chitin deacetylases are closely related and therefore are promising targets for designing novel agrochemicals that target at chitin biosynthesis. This review summarizes the advances in understanding chitin biology over the past decade by our research group and collaborates, specifically regarding essential proteins linked to chitin biosynthesis that can be exploited as promising pesticide targets. Examples of small bioactive molecules that against the activity of these targets are given.
- Chitin biosynthesis,
- Chitin deacetylase,
- Chitinase,
- Hexosaminidase,
- Pesticide,
- Fungicide
1. [1]
  W. Cheng, M. Lin, M. Qiu, et al., Environ. Microbiol. 21 (2019) 4537–4547. doi: 10.1111/1462-2920.14744
2. [2]
  B. Moussian, Chitin: structure, chemistry and biology, in: Q. Yang, T. Fukamizo (Eds. ), Targeting Chitin-containing Organisms, Springer, Singapore, 2019, pp. 5–18.
3. [3]
  A. Schwelm, J. Fogelqvist, A. Knaust, et al., Sci. Rep. 5 (2015) 11153.
4. [4]
  E. Cohen, Chitin biochemistry: synthesis, hydrolysis and inhibition, in: J. Casas, S. Simpson (Eds. ), Advances in Insect Physiology, Academic Press, San Diego, 2010, pp. 5–74.
5. [5]
  H. Merzendorfer, J. Comp. Physiol. B 176 (2006) 1–15. doi: 10.1007/s00360-005-0005-3
6. [6]
  K. Zhu, H. Merzendorfer, W. Zhang, J. Zhang, S. Muthukrishnan, Annu. Rev. Entomol. 61 (2016) 177–196. doi: 10.1146/annurev-ento-010715-023933
7. [7]
  Y. Li, L. Liu, J. Yang, Q. Yang, J. Pestic. Sci. 46 (2021) 43–52.
8. [8]
  G. Courtade, F.L. Aachmann, Chitin-active lytic polysaccharide monooxygenases, in: Q. Yang, T. Fukamizo (Eds. ), Targeting Chitin-containing Organisms, Springer, Singapore, 2019, pp. 115–129.
9. [9]
  B. Moussian, Insect Biochem. Mol. Biol. 40 (2010) 363–375.
10. [10]
  H. Merzendorfer, Eur. J. Cell. Biol. 90 (2011) 759–769.
11. [11]
  M. Qu, Q. Yang, Insect Biochem. Mol. Biol. 41 (2011) 923–931.
12. [12]
  M. Qu, T. Liu, J. Yang, Q. Yang, Biochem. Biophys. Res. Commun. 404 (2011) 302–307.
13. [13]
  M. Qu, Q. Yang, Insect. Mol. Biol. 21 (2012) 395–404. doi: 10.1111/j.1365-2583.2012.01145.x
14. [14]
  W. Chen, P. Cao, Y. Liu, et al., Nature 610 (2022) 402–408. doi: 10.1038/s41586-022-05244-5
15. [15]
  Y. Duan, W. Zhu, X. Zhao, et al., Insect Biochem. Mol. Biol. 141 (2022) 103718.
16. [16]
  W. Zhu, Y. Duan, J. Chen, et al., Insect Biochem. Mol. Biol. 145 (2022) 103783.
17. [17]
  J. Chen, X. Zou, W. Zhu, et al., Insect Biochem. Mol. Biol. 149 (2022) 103845.
18. [18]
  S. Ke, X. Qian, F. Liu, et al., Eur. J. Med. Chem. 44 (2009) 2113–2121.
19. [19]
  S. Ke, F. Liu, N. Wang, Q. Yang, X. Qian, Bioorg. Med. Chem. Lett. 19 (2009) 332–335.
20. [20]
  S. Ke, X. Qian, F. Liu, et al., Eur. J. Med. Chem. 44 (2009) 2985–2993.
21. [21]
  Q. Chen, J. Zhang, L. Chen, et al., Chin. Chem. Lett. 28 (2017) 1232–1237.
22. [22]
  X. Zhang, Z. Yang, H. Xu, et al., J. Agric. Food Chem. 70 (2022) 9262–9275.
23. [23]
  Q. Lu, H. Cui, W. Li, et al., J. Agric. Food Chem. 70 (2022) 10762–10770. doi: 10.1021/acs.jafc.2c04195
24. [24]
  L. Liu, Y. Zhou, M. Qu, et al., J. Biol. Chem. 294 (2019) 5774–5783. doi: 10.1074/jbc.ra119.007597
25. [25]
  L. Liu, M. Qu, T. Liu, et al., J. Insect. Physiol. 113 (2019) 42–48. doi: 10.3390/joitmc5030042
26. [26]
  L. Liu, Y. Xia, Y. Li, et al., Nat. Commun. 14 (2023) 3857.
27. [27]
  X. Zhao, Z. Qin, J. Zhang, et al., Insect Mol. Biol. 28 (2019) 537–549. doi: 10.1111/imb.12569
28. [28]
  J. Zhang, G. Xu, B. Qiu, et al., Insect Biochem. Mol. Biol. 116 (2020) 103264.
29. [29]
  M. Qu, Y. Ren, Y. Liu, Q. Yang, Insect Mol. Biol. 26 (2017) 432–439. doi: 10.1111/imb.12308
30. [30]
  H. Qi, T. Liu, Q. Lu, Q. Yang, J. Agric. Food Chem. 68 (2020) 982–988. doi: 10.1021/acs.jafc.9b06959
31. [31]
  Q. Gong, L. Chen, J. Wang, et al., Biomacromolecules 23 (2022) 2562–2571. doi: 10.1021/acs.biomac.2c00261
32. [32]
  M. Qu, L. Ma, P. Chen, Q. Yang, J. Proteome Res. 13 (2014) 2931–2940. doi: 10.1021/pr5000957
33. [33]
  M. Qu, T. Watanabe-Nakayama, S. Sun, et al., ACS Catal. 10 (2020) 13606–13615. doi: 10.1021/acscatal.0c02751
34. [34]
  Q. Yang, T. Liu, F. Liu, M. Qu, X. Qian, FEBS J 275 (2008) 5690–5702. doi: 10.1111/j.1742-4658.2008.06695.x
35. [35]
  T. Liu, F. Liu, Q. Yang, J. Yang, Protein Expr. Purif. 68 (2009) 99–103.
36. [36]
  T. Liu, H. Zhang, F. Liu, et al., J. Biol. Chem. 286 (2011) 4049–4058. doi: 10.1074/jbc.M110.184796
37. [37]
  T. Liu, H. Zhang, F. Liu, et al., Biochem. J. 438 (2011) 467–474.
38. [38]
  Y. Wang, T. Liu, Q. Yang, Z. Li, X. Qian, Chem. Biol. Drug Des. 79 (2012) 572–582. doi: 10.1111/j.1747-0285.2011.01301.x
39. [39]
  T. Liu, Y. Zhou, L. Chen, et al., PLoS One 7 (2012) e52225. doi: 10.1371/journal.pone.0052225
40. [40]
  T. Liu, Q. Wu, L. Liu, Q. Yang, Process. Biochem. 48 (2013) 103–108.
41. [41]
  T. Liu, M. Qu, Q. Yang, J. Yang, X. Qian, J. Biotechnol. 136 (2008) S109.
42. [42]
  F. Liu, T. Liu, M. Qu, Q. Yang, Int. J. Biol. Sci. 8 (2012) 1085–1096. doi: 10.7150/ijbs.4406
43. [43]
  M. Qu, T. Liu, P. Chen, Q. Yang, PLoS One 8 (2013) e71738. doi: 10.1371/journal.pone.0071738
44. [44]
  Y. Huo, L. Chen, M. Qu, Q. Chen, Q. Yang, Arch. Insect Biochem. Physiol. 83 (2013) 115–126. doi: 10.1002/arch.21099
45. [45]
  Q. Wu, T. Liu, Q. Yang, Insect Sci. 20 (2013) 147–157. doi: 10.1111/j.1744-7917.2012.01512.x
46. [46]
  L. Chen, T. Liu, Y. Zhou, et al., Acta Crystallogr. D: Biol. Crystallogr. 70 (2014) 932–942.
47. [47]
  T. Liu, L. Chen, Y. Zhou, et al., J. Biol. Chem. 292 (2017) 2080–2088.
48. [48]
  W. Chen, M. Qu, Y. Zhou, Q. Yang, J. Biol. Chem. 293 (2018) 2652–2660. doi: 10.1074/jbc.ra117.000119
49. [49]
  M. Qu, S. Sun, Y. Liu, et al., Insect Sci. 28 (2021) 692–704. doi: 10.1111/1744-7917.12791
50. [50]
  T. Liu, W. Zhu, J. Wang, et al., Acta Crystallogr. D: Struct. Biol. 74 (2018) 30–40.
51. [51]
  T. Liu, X. Guo, Y. Bu, et al., Insect Biochem. Mol. Biol. 119 (2020) 103326.
52. [52]
  Q. Chen, W. Chen, A. Kumar, et al., J. Agric. Food Chem. 69 (2021) 3519–3526. doi: 10.1021/acs.jafc.1c00162
53. [53]
  M. Qu, X. Guo, S. Tian, et al., Commun. Biol. 5 (2022) 518.
54. [54]
  M. Qu, X. Guo, L. Kong, L. Hou, Q. Yang, Insect Sci. 29 (2022) 1287–1298. doi: 10.1111/1744-7917.13016
55. [55]
  Y. Yang, T. Liu, Y. Yang, et al., ChemBioChem 12 (2011) 457–467. doi: 10.1002/cbic.201000561
56. [56]
  T. Liu, P. Guo, Y. Zhou, et al., Sci. Rep. 4 (2014) 6188.
57. [57]
  T. Liu, M. Xia, H. Zhang, et al., FEBS Lett. 589 (2015) 110–116. doi: 10.1016/j.febslet.2014.11.032
58. [58]
  L. Chen, T. Liu, Y. Duan, X. Lu, Q. Yang, J. Agric. Food Chem. 65 (2017) 3851–3857. doi: 10.1021/acs.jafc.7b01710
59. [59]
  Y. Duan, T. Liu, Y. Zhou, T. Dou, Q. Yang, J. Biol. Chem. 293 (2018) 15429–15438. doi: 10.1074/jbc.ra118.004351
60. [60]
  H. Yang, T. Liu, H. Qi, et al., Bioorg. Med. Chem. 26 (2018) 5420–5426.
61. [61]
  H. Yang, H. Qi, T. Liu, et al., Chin. Chem. Lett. 30 (2019) 977–980.
62. [62]
  H. Yang, H. Qi, Z. Hao, et al., Chin. Chem. Lett. 31 (2020) 1271–1275.
63. [63]
  S. Shen, L. Dong, W. Chen, et al., J. Agric. Food Chem. 67 (2019) 6387–6396. doi: 10.1021/acs.jafc.9b02281
64. [64]
  L. Dong, S. Shen, W. Chen, et al., Bioorg. Med. Chem. 27 (2019) 2315–2322.
65. [65]
  P. Liang, Q. Xu, R. Chen, et al., Carbohydr. Res. 520 (2022) 108629.
66. [66]
  Y. Dong, S. Hu, X. Zhao, et al., Pest Manag. Sci. 76 (2020) 3030–3037. doi: 10.1002/ps.5852
67. [67]
  L. Dong, S. Shen, Y. Xu, et al., J. Biomol. Struct. Dyn. 39 (2021) 1735–1743. doi: 10.1080/07391102.2020.1743758
68. [68]
  T. Chen, W. Li, Z. Liu, et al., J. Agric. Food Chem. 69 (2021) 12039–12047. doi: 10.1021/acs.jafc.1c01642
69. [69]
  P. Guo, Q. Chen, T. Liu, et al., ACS Med. Chem. Lett. 4 (2013) 527–531. doi: 10.1021/ml300475m
70. [70]
  Q. Chen, P. Guo, L. Xu, et al., Biochimie 97 (2014) 152–162.
71. [71]
  H. Kong, W. Chen, H. Lu, et al., Carbohydr. Res. 413 (2015) 135–144.
72. [72]
  H. Kong, W. Chen, T. Liu, et al., Carbohydr. Res. 429 (2016) 54–61.
73. [73]
  W. Chen, S. Shen, L. Dong, J. Zhang, Q. Yang, Bioorg. Med. Chem. 26 (2018) 394–400.
74. [74]
  S. Shen, W. Chen, L. Dong, et al., J. Enzyme Inhib. Med. Chem. 33 (2018) 445–452. doi: 10.1080/14756366.2017.1419217
75. [75]
  L. Chen, Y. Zhou, M. Qu, Y. Zhao, Q. Yang, J. Biol. Chem. 289 (2014) 17932–17940.
76. [76]
  X. Jiang, A. Kumar, T. Liu, K. Zhang, Q. Yang, J. Chem. Inf. Model. 56 (2016) 2413–2420. doi: 10.1021/acs.jcim.6b00615
77. [77]
  Y. Dong, X. Jiang, T. Liu, et al., J. Agric. Food Chem. 66 (2018) 3351–3357. doi: 10.1021/acs.jafc.8b00017
78. [78]
  Y. Dong, S. Hu, X. Jiang, et al., J. Agric. Food Chem. 67 (2019) 3575–3582. doi: 10.1021/acs.jafc.9b00837
79. [79]
  B. Jiang, X. Jin, Y. Dong, et al., J. Agric. Food Chem. 68 (2020) 6347–6354. doi: 10.1021/acs.jafc.0c00522
80. [80]
  B. Jiang, B. Guo, J. Cui, et al., Bioorg. Med. Chem. Lett. 30 (2020) 127500.
81. [81]
  Q. Han, N. Wu, H. Li, et al., J. Agric. Food Chem. 69 (2021) 7534–7544. doi: 10.1021/acs.jafc.0c08119
82. [82]
  Q. Han, N. Wu, J. Zhang, et al., J. Agric. Food Chem. 71 (2023) 18685–18695. doi: 10.1021/acs.jafc.3c05287
83. [83]
  W. Chen, Y. Zhou, Q. Yang, J. Biol. Chem. 294 (2019) 9358–9364. doi: 10.1074/jbc.ra119.007812
84. [84]
  X. Jiang, A. Kumar, Y. Motomura, et al., J. Med. Chem. 63 (2020) 987–1001. doi: 10.1021/acs.jmedchem.9b01154
85. [85]
  L. Dong, S. Shen, X. Jiang, et al., J. Agric. Food Chem. 70 (2022) 12203–12210. doi: 10.1021/acs.jafc.2c03997
86. [86]
  P. Yuan, X. Jiang, S. Wang, et al., J. Agric. Food Chem. 68 (2020) 13584–13593. doi: 10.1021/acs.jafc.0c03742
87. [87]
  L. Zhu, L. Chen, X. Shao, et al., J. Agric. Food Chem. 69 (2021) 7526–7533. doi: 10.1021/acs.jafc.0c07401
88. [88]
  Q. Lu, L. Xu, L. Liu, et al., J. Agric. Food Chem. 69 (2021) 14086–14091. doi: 10.1021/acs.jafc.1c05385
89. [89]
  Z. Zhao, Q. Xu, W. Chen, et al., J. Agric. Food Chem. 70 (2022) 4889–4898. doi: 10.1021/acs.jafc.2c00016
90. [90]
  H. Qi, X. Jiang, Y. Ding, T. Liu, Q. Yang, Front Mol. Biosci. 8 (2021) 640356.
91. [91]
  W. Li, Y. Ding, H. Qi, T. Liu, Q. Yang, J. Agric. Food Chem. 69 (2021) 10830–10837. doi: 10.1021/acs.jafc.1c03629
92. [92]
  Y. Ding, S. Chen, F. Zhang, et al., J. Agric. Food Chem. 71 (2023) 1845–1851. doi: 10.1021/acs.jafc.2c06607
93. [93]
  Y. Ding, S. Chen, H. Liu, T. Liu, Q. Yang, J. Agric. Food Chem. 71 (2023) 8769–8777. doi: 10.1021/acs.jafc.3c00633
94. [94]
  Z. Jiang, D. Shi, H. Li, et al., J. Agric. Food Chem. 70 (2022) 10326–10336. doi: 10.1021/acs.jafc.2c03751
95. [95]
  Q. Han, N. Wu, Y. Liu, et al., J. Agric. Food Chem. 70 (2022) 7387–7399. doi: 10.1021/acs.jafc.2c02091
96. [96]
  X. Jin, T. Sun, B. Guo, et al., J. Agric. Food Chem. 71 (2023) 8345–8355. doi: 10.1021/acs.jafc.3c00775
97. [97]
  Z. Zhao, W. Chen, Y. Dong, et al., J. Agric. Food Chem. 71 (2023) 12431–12439. doi: 10.1021/acs.jafc.3c02448
98. [98]
  L. Chen, L. Zhu, J. Chen, et al., J. Enzyme Inhib. Med. Chem. 35 (2020) 1937–1943. doi: 10.1080/14756366.2020.1837123
99. [99]
  W. Chen, Q. Chen, A. Kumar, et al., J. Enzyme Inhib. Med. Chem. 36 (2021) 1198–1204. doi: 10.1080/14756366.2021.1931862
100. [100]
  S. Shen, B. Ding, X. Jiang, et al., Front Chem. 10 (2022) 1021295.
101. [101]
  X. Jin, T. Sun, X. Zhang, et al., J. Agric. Food Chem. 71 (2023) 244–254. doi: 10.1021/acs.jafc.2c06516
102. [102]
  E. Cohen, Pest Manag. Sci. 57 (2001) 946–950.
103. [103]
  F. Matsumura, Pestic. Biochem. Phys. 97 (2010) 133–139.
104. [104]
  H. Merzendorfer, Insect Sci. 20 (2013) 121–138. doi: 10.1111/j.1744-7917.2012.01535.x
105. [105]
  H. Merzendorfer, L. Zimoch, J. Exp. Biol. 206 (2003) 4393–4412.
106. [106]
  S. Muthukrishnan, H. Merzendorfer, Y. Arakane, K.J. Kramer, Chitin metabolism in insects, in: L. Gilbert (Ed. ), Insect Molecular Biology and Biochemistry, Academic Press, San Diego, 2012, pp. 193–235.
107. [107]
  S. Muthukrishnan, H. Merzendorfer, Y. Arakane, Q. Yang, Chitin metabolic pathways in insects and their regulation, in: E. Cohen, B. Moussian (Eds. ), Extracellular Composite Matrices in Arthropods, Springer, Cham, 2016, pp. 31–65.
108. [108]
  Q. Yang, T. Fukamizo, Targeting Chitin-containing Organisms, 1st. ed, Springer, Singapore, 2019.
109. [109]
  W. Chen, X. Jiang, Q. Yang, Biotechnol. Adv. 43 (2020) 107553.
110. [110]
  A. Yu, M. Beck, H. Merzendorfer, Q. Yang, Insect Biochem. Mol. Biol. 164 (2023) 104058.
111. [111]
  T. Liu, Y. Duan, Q. Yang, Biotechnol. Adv. 36 (2018) 1127–1138.
112. [112]
  W. Chen, Q. Yang, J. Agric. Food Chem. 68 (2020) 4559–4565. doi: 10.1021/acs.jafc.0c00888
113. [113]
  Y. Ding, Q. Lu, T. Liu, Q. Yang, Adv. Agrochem. 2 (2023) 306–312.
114. [114]
  Q. Lu, H. Xie, M. Qu, T. Liu, Q. Yang, J. Agric. Food Chem. 71 (2023) 5944–5952.
1. [1]
  Chu Wu , Zhichao Dong , Jinfang Hou , Jian Peng , Shuangyu Wu , Xiaofang Wang , Xiangwei Kong , Yue Jiang . Application of titanium-based advanced oxidation processes in pesticide-contaminated water purification: Emerging opportunities and challenges. Chinese Chemical Letters, 2025, 36(3): 110438-. doi: 10.1016/j.cclet.2024.110438
2. [2]
  Shuaige Bai , Shuai Huang , Ting Luo , Bin Feng , Yanpeng Fang , Feiyi Chu , Jie Dong , Wenbin Zeng . Debut of a responsive chemiluminescent probe for butyrylcholinesterase: Application in biological imaging and pesticide residue detection. Chinese Chemical Letters, 2025, 36(3): 110054-. doi: 10.1016/j.cclet.2024.110054
3. [3]
  Fenglin Jiang , Anan Liu , Qian Wei , Youcai Hu . Editing function of type Ⅱ thioesterases in the biosynthesis of fungal polyketides. Chinese Chemical Letters, 2024, 35(10): 109504-. doi: 10.1016/j.cclet.2024.109504

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(71)
HTML views(4)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142