Citation: Sixin Ai, Wenxiu Li, Huayong Zhu, Yang Wan, Weiying Lin. Viscosity-responsive signal amplification dual-modal probe triggered by cysteine/homocysteine for monitoring diabetic liver damages and repair processes[J]. Chinese Chemical Letters, ;2025, 36(3): 109904. doi: 10.1016/j.cclet.2024.109904 shu

Viscosity-responsive signal amplification dual-modal probe triggered by cysteine/homocysteine for monitoring diabetic liver damages and repair processes

Institute of Optical Materials and Chemical Biology, Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China

weiyinglin2013@163.com

Received Date: 8 February 2024
Revised Date: 12 April 2024
Accepted Date: 16 April 2024
Available Online: 17 April 2024

Figures(6)

Diabetic liver injury is a widespread complication of diabetes and carries a high risk to liver function. Therefore, early diagnosis of diabetic liver injury is of great significance for providing quality of life for diabetic patients. Most of the activated dual-modal probes are usually activated by single factor stimulation, which greatly reduces the diagnostic accuracy of liver injury. Here, a novel cysteine (Cys)/homocysteine (Hcy) and viscosity-enhanced dual-modal probe DAL was developed for the first time to monitor diabetic liver injury and its repair process. In the presence of Cys/Hcy, the near-infrared fluorescence (NIRF) and photoacoustic (PA) signals of the probe DAL were activated, with further signal enhancement in high viscosity environments. This Cys/Hcy and viscosity cascade probe exhibits heightened sensitivity and enhanced anti-interference capabilities, contributing to the advancement of liver injury diagnosis accuracy. In addition, the probe DAL shows exceptional mitochondrial targeting ability, enabling sensitive monitoring of Cys/Hcy and viscosity alterations within mitochondria. Based on NIRF/PA dual-modal imaging technology, the probe was successfully used for the first time in a mouse diabetic liver injury model to evaluate the extent of liver damage and the repair process by tracking the levels of Cys/Hcy and viscosity. Therefore, the two-factor activated dual-modal probe developed in this study provides a powerful instrument for accurate diagnosis and efficacy evaluation of complications related to diabetes.
- Cysteine/homocysteine,
- Viscosity responsive,
- Near-infrared fluorescence,
- Photoacoustic imaging,
- Fluorescence imaging
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