Citation: Yuequan Wang, Congtian Wu, Chengcheng Feng, Qin Chen, Zhonggui He, Shenwu Zhang, Cong Luo, Jin Sun. Spatiotemporally-controlled supramolecular hybrid nanoassembly enabling ferroptosis-augmented photodynamic immunotherapy of cancer[J]. Chinese Chemical Letters, ;2025, 36(3): 109902. doi: 10.1016/j.cclet.2024.109902 shu

Spatiotemporally-controlled supramolecular hybrid nanoassembly enabling ferroptosis-augmented photodynamic immunotherapy of cancer

Yuequan Wang ^a ,
Congtian Wu ^a ,
Chengcheng Feng ^a ,
Qin Chen ^c ,
Zhonggui He ^{a, b} ,
Shenwu Zhang ^{a, b, *,} ,
Cong Luo ^{a, b, *,} ,
Jin Sun ^{a, b, *,}

a.
Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
b.
Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
c.
Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China

zhangshenwu@aliyun.com

luocong@syphu.edu.cn

sunjin@syphu.edu.cn

Received Date: 8 March 2024
Revised Date: 14 April 2024
Accepted Date: 16 April 2024
Available Online: 16 April 2024

Figures(5)

Photodynamic therapy (PDT) not only directly eradicates tumor cells but also boosts immunogenicity, promoting antigen presentation and immune cell infiltration. However, the robust antioxidant defense mechanisms within tumor cells significantly weaken the efficacy of photodynamic immunotherapy. Herein, a supramolecular hybrid nanoassembly is constructed by exploring the synergistic effects of the photodynamic photosensitizer (pyropheophorbide a, PPa) and the ferroptosis inducer (erastin). The erastin-mediated inhibition of system X_c⁻ significantly downregulates glutathione (GSH) expression, amplifying intracellular oxidative stress, leading to pronounced cell apoptosis, and promoting the release of damage-associated molecular patterns (DAMPs). Additionally, the precise cooperation of PPa and erastin enhances ferroptosis efficiency, exacerbating the accumulation of lipid peroxides (LPOs). Ultimately, LPOs serve as a "find me" signal, while DMAPs act as an "eat me" signal, collectively promoting dendritic cell maturation, enhancing infiltration of the cytotoxic T lymphocytes, and eliciting a robust immune response. This study opens new horizons for enhancing tumor immunotherapy through simultaneous ferroptosis-PDT.
- Supermolecule,
- Nanoasssembly,
- Ferroptosis,
- Photodynamic therapy,
- Immunotherapy
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沈阳化工大学材料科学与工程学院沈阳 110142