Citation: Fan Zheng, Runsha Xiao, Shuai Huang, Zhikang Chen, Chen Lai, Anyao Bi, Heying Yao, Xueping Feng, Zihua Chen, Wenbin Zeng. Accurate visualization colorectal cancer by monitoring viscosity variations with a novel mitochondria-targeted fluorescent probe[J]. Chinese Chemical Letters, ;2025, 36(2): 109876. doi: 10.1016/j.cclet.2024.109876 shu

Accurate visualization colorectal cancer by monitoring viscosity variations with a novel mitochondria-targeted fluorescent probe

Fan Zheng ^{a, b, 1} ,
Runsha Xiao ^{c, d, e, 1} ,
Shuai Huang ^{a, b} ,
Zhikang Chen ^{c, d, e} ,
Chen Lai ^{c, d, e} ,
Anyao Bi ^{a, b} ,
Heying Yao ^{a, b} ,
Xueping Feng ^{e, f, g} ,
Zihua Chen ^{c, d, e, *,} ,
Wenbin Zeng ^{a, b, *,}

a.
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
b.
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha 410013, China
c.
Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China
d.
Hunan Key Laboratory of Precise Diagnosis and Treatment of Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha 410008, China
e.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
f.
Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China
g.
Department of Otolaryngology-head and Neck Surgery and Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha 410008, China

zihuac@outlook.com

wbzeng@hotmail.com

Received Date: 13 February 2024
Revised Date: 2 April 2024
Accepted Date: 8 April 2024
Available Online: 9 April 2024

Figures(5)

Colorectal cancer (CRC) is one of the most prevalent malignant tumors worldwide, exhibiting high morbidity and mortality. Lack of efficient tools for early diagnosis and surgical resection guidance of CRC have been a serious threat to the long-term survival rate of the CRC patients. Recent studies have shown that relative higher viscosity was presented in tumor cells compared to that in normal cells, leading to viscosity as a potential biomarker for CRC. Herein, we reported the development of a series of novel viscosity-sensitive and mitochondria-specific fluorescent probes (HTB, HTI, and HTP) for CRC detection. Among them, HTB showed high sensitivity, minimal background interference, low cytotoxicity, and significant viscous response capability, making it an ideal tool for distinguishing colorectal tumor cells from normal cells. Importantly, we have successfully utilized HTB to visualize in a CRC-cells-derived xenograft (CDX) model, enriching its medical imaging capacity, which laid a foundation for further clinical translational application.
- Fluorescent probe,
- Viscosity,
- Bioimaging,
- Colorectal cancer,
- Cancer diagnosis,
- Mitochondrial-targeted
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沈阳化工大学材料科学与工程学院沈阳 110142