Citation: Yun-Feng Liu, Hui-Fang Du, Ya-Hui Zhang, Zhi-Qin Liu, Xiao-Qian Qi, Du-Qiang Luo, Fei Cao. Chaeglobol A, an unusual octocyclic sterol with antifungal activity from the marine-derived fungus Chaetomium globosum HBU-45[J]. Chinese Chemical Letters, ;2025, 36(3): 109858. doi: 10.1016/j.cclet.2024.109858 shu

Chaeglobol A, an unusual octocyclic sterol with antifungal activity from the marine-derived fungus Chaetomium globosum HBU-45

Yun-Feng Liu ^{a, b, 1} ,
Hui-Fang Du ^{a, 1} ,
Ya-Hui Zhang ^c ,
Zhi-Qin Liu ^{a, *,} ,
Xiao-Qian Qi ^a ,
Du-Qiang Luo ^c ,
Fei Cao ^{a, *,}

a.
College of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China
b.
College of Horticulture, Hebei Agricultural University, Baoding 071001, China
c.
College of Life Sciences, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei University, Baoding 071002, China

zhiqinliu999@126.com

caofei542927001@163.com

Received Date: 2 February 2024
Revised Date: 30 March 2024
Accepted Date: 3 April 2024
Available Online: 4 April 2024

Figures(7)

Chemical investigation of the marine-derived fungus Chaetomium globosum HBU-45 led to the discovery of chaeglobol A (1). Its structure was determined by spectroscopic analysis, computational electronic circular dichroism (ECD)/optical rotatory dispersion (ORD) methods, and X-ray crystallography. Compound 1 represents a new skeleton with an uncommon 6/6/6/5/6/5/6/5 octacyclic system, which is presumably biosynthesized via a [4 + 2] cycloaddition and an enzymatic cyclization. Chaeglobol A (1) exhibited inhibitory activity against B. dothidea by destroying cell membrane integrity and causing oxidative damage within the cells.
- Marine-derived fungus,
- Chaetomium globosum,
- Octocyclic sterol,
- Antifungal activity,
- Single-crystal X-ray diffraction
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