Citation: Yingtao Zhong, Ziwen Qiu, Yanmei Li, Jiaqi Huang, Zhenming Lu, Renjiang Kong, Ni Yan, Hong Cheng. Nutrients deprivation of biomimetic nanozymes for cascade catalysis triggered and oxidative damage induced tumor eradication[J]. Chinese Chemical Letters, ;2025, 36(3): 109846. doi: 10.1016/j.cclet.2024.109846 shu

Nutrients deprivation of biomimetic nanozymes for cascade catalysis triggered and oxidative damage induced tumor eradication

School of Biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, China

chengh@smu.edu.cn

Received Date: 25 February 2024
Revised Date: 25 March 2024
Accepted Date: 31 March 2024
Available Online: 1 April 2024

Figures(6)

Deprivation of glucose and lactate provides an effective pathway to terminate the nutrients supplement for tumor growth. In this work, biomimetic nanozymes called m@BGLC are constructed for catalytic tumor inhibition through nutrients deprivation and oxidative damage induction. Concretely, the catalytic enzymes of glucose oxidase (GOx), lactate oxidase (LOx) and chloroperoxidase (CPO) are precrosslinked with bovine serum albumin (BSA) to construct nanozymes, which are then biomimetic functionalized with cancer cell membrane to prepare m@BGLC. Benefiting from the biomimetic camouflage with homologous cell membrane, m@BGLC inherit homotypic binding and immune escape abilities, facilitating the tumor targeting accumulation and preferable cell internalization for improved drug delivery efficiency. Subsequently, under the cascade catalysis of nanozymes, m@BGLC consume glucose and lactate for tumor starvation therapy through nutrients deprivation, and meanwhile, the resulting hyprochloric acid (HClO) causes an oxidative damage of cells to synergistically inhibit tumor growth. In vitro and in vivo findings demonstrate a robust tumor eradication effect of m@BGLC without obvious adverse reactions via the targeted combination therapy. Such cascade catalytic nanomedicine may inspire the development of sophisticated strategies for tumor combination therapy under unfavorable tumor microenvironments.
- Biomimetic nanozymes,
- Cascade catalysis,
- Nutrients deprivation,
- Starvation therapy,
- Oxidative damage
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