Citation: Junmeng Luo, Qiongqiong Wan, Suming Chen. Chemistry-driven mass spectrometry for structural lipidomics at the C=C bond isomer level[J]. Chinese Chemical Letters, ;2025, 36(1): 109836. doi: 10.1016/j.cclet.2024.109836 shu

Chemistry-driven mass spectrometry for structural lipidomics at the C=C bond isomer level

The Institute for Advanced Studies, Wuhan University, Wuhan 430072, China

wan.qq@whu.edu.cn

sm.chen@whu.edu.cn

Received Date: 19 September 2023
Revised Date: 28 February 2024
Accepted Date: 25 March 2024
Available Online: 26 March 2024

Figures(9)

As more and more studies have shown that lipid molecules play an important role in the whole biology, in-depth analysis of lipid structure has become particularly important in lipidomics. Mass spectrometry (MS), as the preferred tool for lipid analysis, has greatly promoted the development of this field. However, the existing MS methods still face many difficulties in the in-depth or even comprehensive analysis of lipid structure. In this review, we discuss recent advances in MS methods based on double bond-specific chemistries for the resolving of C=C location and geometry isomers of lipids. This progress has greatly advanced the lipidomics analysis to a deeper structural level and facilitated the development of structural lipid biology.
- Mass spectrometry,
- Structural lipidomics,
- Lipid isomers,
- Double bond location,
- Double bond configuration,
- Chemical derivatization
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