Citation: Lanyun Zhang, Weisi Wang, Yu-Qiang Zhao, Rui Huang, Yuxun Lu, Ying Chen, Liping Duan, Ying Zhou. Mechanism study of the molluscicide candidate PBQ on Pomacea canaliculata using a viscosity-sensitive fluorescent probe[J]. Chinese Chemical Letters, ;2025, 36(1): 109798. doi: 10.1016/j.cclet.2024.109798 shu

Mechanism study of the molluscicide candidate PBQ on Pomacea canaliculata using a viscosity-sensitive fluorescent probe

Lanyun Zhang ^a ,
Weisi Wang ^b ,
Yu-Qiang Zhao ^a ,
Rui Huang ^a ,
Yuxun Lu ^a ,
Ying Chen ^b ,
Liping Duan ^{b, *,} ,
Ying Zhou ^{a, *,}

a.
Yunnan Characteristic Plant Extraction Laboratory, College of Chemical Science and Technology, Yunnan University, Kunming 650091, China
b.
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research, WHO Centre for Tropical Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Key Laboratory on Parasite and Vector Biology Ministry of Health, Shanghai 200025, China

duanlp@nipd.chinacdc.cn

yingzhou@ynu.edu.cn

Received Date: 30 January 2024
Revised Date: 13 March 2024
Accepted Date: 19 March 2024
Available Online: 20 March 2024

Figures(6)

PBQ [1-(4-chlorophenyl)-3-(pyridin-3-yl)urea], an enormous potent molluscicide, showed excellent Pomacea canaliculata (P. canaliculata) control activity and low toxicity for other aquatic organisms, but its snail-killing mechanisms are still not fully understood. We employed an optical method to elucidate PBQ action via a novel fluorescent viscosity probe, NCV. As the viscosity in the test solutions increased, compared with that in pure ethanol, a 54-fold fluorescence intensity enhancement of NCV was observed in 310 cP of 90% glycerol. Furthermore, NCV successfully exhibited a selective fluorescence response towards monensin-induced cellular viscosity changes in HepG2 cells. The liver, stomach, and foot plantar of the tested snails were frozen and sectioned for fluorescent imaging experiments after the treatment with different PBQ concentrations over various times. A significant fluorescent increase in the snail's liver was observed upon exposure to 0.75 mg/L PBQ for 72 h, which highlighted an increase in viscosity. Hematoxylin and eosin (HE) staining further supported PBQ-induced liver damage with a viscosity increase in P. canaliculata. Our study provides a new rapid optical visualization method to study the killing mechanisms of PBQ and may help discover new chemicals that control snail populations.
- Fluorescence sensor,
- Viscosity,
- Pomacea canaliculata,
- Molluscicide mechanisms,
- Bio-imaging
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