Citation: Yang Xu, Le Ma, Yang Wang, Chunmeng Shi. Engineering strategies of biomaterial-assisted exosomes for skin wound repair: Latest advances and challenges[J]. Chinese Chemical Letters, ;2025, 36(1): 109766. doi: 10.1016/j.cclet.2024.109766 shu

Engineering strategies of biomaterial-assisted exosomes for skin wound repair: Latest advances and challenges

Institute of Rocket Force Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University (Army Medical University), Chongqing 400038, China

shicm@sina.com

Received Date: 29 January 2024
Revised Date: 11 March 2024
Accepted Date: 12 March 2024
Available Online: 13 March 2024

Figures(1)

The treatment of skin wounds, especially chronic wounds, remains a critical clinical challenge and places a heavy burden on patients and healthcare systems. In recent years, the engineering strategy of using biomaterial-assisted exosomes has emerged as a powerful tool for skin repair. Compared to treatments such as debridement and regular dressing changes, the design of biomaterial-assisted exosomes not only maintains the bioactivity of exosomes at the wound site but also provides an appropriate microenvironment for the repair of complex tissues, thereby accelerating wound healing. This review systematically introduces the general characteristics of exosomes and their functions in skin wound healing, highlights recent advances in classification of natural exosomes and engineering methods which enriching their functions in intercellular communication. Then, various emerging and innovative approaches based on biomaterials delivery of exosomes are comprehensively discussed. The review seeks to bring an in-depth understanding of bioactive dressings based on exosomes therapeutic strategies, aiming to facilitate new clinical application value.
- Exosomes,
- Biomaterials,
- Hydrogel,
- Delivery system,
- Wound healing
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