Citation: Wenbin Zhou, Yafei Gao, Xinyu Feng, Yanqing Zhang, Cong Yang, Lanxi He, Fenghe Zhang, Xiaoguang Li, Qing Li. Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC[J]. Chinese Chemical Letters, ;2025, 36(1): 109763. doi: 10.1016/j.cclet.2024.109763 shu

Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC

Wenbin Zhou ^{a, b, c, 1} ,
Yafei Gao ^{a, b, c, 1} ,
Xinyu Feng ^{a, b, c} ,
Yanqing Zhang ^{a, b, c} ,
Cong Yang ^{a, b, c} ,
Lanxi He ^{a, b, c} ,
Fenghe Zhang ^{a, b, c, *,} ,
Xiaoguang Li ^{d, *,} ,
Qing Li ^{a, b, c, *,}

a.
School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Ji'nan 250012, China
b.
China & Shandong Key Laboratory of Oral Tissue Regeneration, Ji'nan 250012, China
c.
China & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Ji'nan 250012, China
d.
Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan 250021, China

zfengh@sdu.edu.cn

xiaopa3084@126.com

lq580202@sdu.edu.cn

Received Date: 16 February 2024
Revised Date: 9 March 2024
Accepted Date: 11 March 2024
Available Online: 12 March 2024

Figures(5)

Immunotherapy offers significant potential but is often hampered by the immunosuppressive environment in oral squamous cell carcinoma (OSCC). To address this, we propose an enhanced immunotherapeutic strategy that revitalizes the tumor immune microenvironment (TIME) in OSCC by integrating upconversion-based photodynamic therapy (PDT) with chemotherapy. Using a red blood cell membrane-inspired biomimetic nanoplatform, our approach concurrently delivers chlorin e6@upconversion nanoparticles (Ce6@UCNP) and doxorubicin (DOX). By leveraging fluorescence resonance energy transfer (FRET) for 980 nm to 660 nm upconversion excitation, we address challenges such as limited tissue penetration and tissue damage, as well as nanoplatform issues including immunogenicity and targeting inaccuracy Our integrated approach enhances PDT and chemotherapy with the goal of transforming immunologically "cold" tumors into "hot" ones through a cascaded therapy, thereby revitalizing the tumor immune microenvironment in OSCC.
- Biomimetic nanoplatform,
- UCNP-PDT,
- Chemotherapy,
- TIME,
- OSCC
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