Citation: Zhongyu Wang, Lijun Wang, Huaixin Zhao. DNA-based nanosystems to generate reactive oxygen species for nanomedicine[J]. Chinese Chemical Letters, ;2024, 35(11): 109637. doi: 10.1016/j.cclet.2024.109637 shu

DNA-based nanosystems to generate reactive oxygen species for nanomedicine

Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), Institute of Biomolecular and Biomedical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China

huaixin.zhao@tju.edu.cn

Received Date: 28 October 2023
Revised Date: 16 January 2024
Accepted Date: 8 February 2024
Available Online: 11 February 2024

Figures(5)

Reactive oxygen species (ROS) are essential in various pathological and physiological processes. Developing nanosystems that generate ROS in a controlled manner is of great interest for nanomedicine. DNA nanotechnology offers a promising approach to constructing programmable ROS-generating platforms. By incorporating photosensitizers or metal ions, DNA nanostructures can be designed to produce ROS in a spatially and temporally desired fashion. DNA-based ROS-generating nanosystems hold great potential in intracellular homeostasis regulation, drug release, and cancer therapy. This review summarizes recent advances in developing DNA-based ROS-generating nanosystems, highlights their emerging biomedical applications, and discusses the opportunities and challenges for further applications. DNA nanotechnology provides a versatile toolkit to construct biocompatible ROS-generating platforms for next-generation nanomedicines.
- DNA nanotechnology,
- Photodynamic therapy,
- Chemodynamic therapy,
- Reactive oxygen species,
- Nanomedicine
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