Citation: Zhendong Liu, Sainan Liu, Bin Liu, Qi Meng, Meng Yuan, Chunzheng Yang, Yulong Bian, Ping'an Ma, Jun Lin. Fe(Ⅲ)-juglone nanoscale coordination polymers for cascade chemodynamic therapy through synergistic ferroptosis and apoptosis strategy[J]. Chinese Chemical Letters, ;2024, 35(11): 109626. doi: 10.1016/j.cclet.2024.109626 shu

Fe(Ⅲ)-juglone nanoscale coordination polymers for cascade chemodynamic therapy through synergistic ferroptosis and apoptosis strategy

Zhendong Liu ^{a, b} ,
Sainan Liu ^a ,
Bin Liu ^c ,
Qi Meng ^{a, b} ,
Meng Yuan ^{a, b} ,
Chunzheng Yang ^{a, b} ,
Yulong Bian ^{a, b} ,
Ping'an Ma ^{a, b, *,} ,
Jun Lin ^{a, b, *,}

a.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
c.
College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, China

mapa675@ciac.ac.cn

jlin@ciac.ac.cn

Received Date: 7 December 2023
Revised Date: 31 January 2024
Accepted Date: 3 February 2024
Available Online: 13 February 2024

Figures(5)

Chemodynamic therapy (CDT) relying on the transformation of endogenous hydrogen peroxide (H₂O₂) into cytotoxic hydroxyl radicals (•OH) based on the catalysis of Fenton/Fenton-type reactions exhibits great potentiality for cancer treatment. However, the inadequate H₂O₂ supply and intricate redox homeostasis in tumor microenvironment (TME) severely impair the efficacy of CDT. Herein, we design self-assembled 1,2-distearoyl-sn-glycero-3-phosphoethanolamine conjugated polyethylene glycol (DSPE-PEG)-modified Fe(Ⅲ)-juglone nanoscale coordination polymers (FJP NCPs) as redox homeostasis disruptors for juglone-enhanced CDT. Responding to glutathione (GSH)-rich and acidic TME, the Fe²⁺/Fe³⁺-guided CDT and GSH consumption by Fe³⁺ are activated, resulting in •OH downstream and up-regulation of lipid peroxidation (LPO). In addition, the released juglone not only depletes GSH through Michael addition, but also elevates intracellular H₂O₂ level for achieving •OH further bursting. With the impressive efficiency of GSH exhaustion and reactive oxygen species (ROS) storm generation, ferroptosis and apoptosis are significantly enhanced by FJP NCPs in vivo. In brief, this facile and efficient design for versatile nanoscale coordination polymers presents a novel paradigm for effectively elevating CDT efficiency and tumor synergistic therapy.
- Nanoscale coordination polymers,
- Juglone,
- Tumor microenvironment,
- Enhanced chemodynamic therapy,
- Ferroptosis
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