Citation: Zhipeng Li, Qincong Feng, Jianliang Shen. A β-lactamase-activatable photosensitizer for the treatment of resistant bacterial infections[J]. Chinese Chemical Letters, ;2024, 35(11): 109602. doi: 10.1016/j.cclet.2024.109602 shu

A β-lactamase-activatable photosensitizer for the treatment of resistant bacterial infections

Zhipeng Li ^a ,
Qincong Feng ^a ,
Jianliang Shen ^{a, b, *,}

a.
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
b.
Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China

shenjl@wiucas.ac.cn

Received Date: 6 December 2023
Revised Date: 28 January 2024
Accepted Date: 29 January 2024
Available Online: 6 February 2024

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Antibacterial agent of activatable photosensitizer not only has the advantages of traditional photosensitizers, such as good curative effect and low resistance, but also has better selectivity for bacteria and lower toxicity to normal tissues. Limited reports of activatable photosensitizer can be used to treat drug-resistant bacteria. In order to meet this challenge, we designed and synthesized an activatable photosensitizer (Ce-OHOA), which can not only selectively identify methicillin-resistant Staphylococcus aureus (MRSA) with high expression of β-lactamase by fluorescence imaging, but also kill MRSA with less than 10 times the concentration and 10 times the irradiation dose of CySG-2 reported. Ce-OHOA not only combines the dual functions of fluorescence diagnosis and photodynamic therapy, but also selectively acts on bacteria with high expression of β-lactamase and has little toxicity to normal cells. We expect that the study of this activating photosensitizer will provide a new solution for antibacterial photodynamic therapy (aPDT) of drug-resistant bacteria.
- Activatable photosensitizer,
- MRSA,
- β-Lactamase,
- Fluorescence imaging,
- aPDT
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