Citation: Lihang Wang, Mary Li Javier, Chunshan Luo, Tingsheng Lu, Shudan Yao, Bing Qiu, Yun Wang, Yunfeng Lin. Research advances of tetrahedral framework nucleic acid-based systems in biomedicine[J]. Chinese Chemical Letters, ;2024, 35(11): 109591. doi: 10.1016/j.cclet.2024.109591 shu

Research advances of tetrahedral framework nucleic acid-based systems in biomedicine

Lihang Wang ^a ,
Mary Li Javier ^b ,
Chunshan Luo ^a ,
Tingsheng Lu ^a ,
Shudan Yao ^a ,
Bing Qiu ^{a, *,} ,
Yun Wang ^{b, *,} ,
Yunfeng Lin ^{b, c, *,}

a.
Department of Spine Surgery, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang 550014, China
b.
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
c.
Sichuan Provincial Engineering Research Center of Oral Biomaterials, Chengdu 610041, China

yz8088gk@163.com

wy630ivy@outlook.com

yunfenglin@scu.edu.cn

Received Date: 10 December 2023
Revised Date: 30 January 2024
Accepted Date: 31 January 2024
Available Online: 2 February 2024

Figures(2)

This article reviews the latest research advances of tetrahedral framework nucleic acid (tFNA)-based systems in their fabrication, modification, and the potential applications in biomedicine. TFNA arises from the synthesis of four single-stranded DNA chains. Each chain contains brief sequences that complement those found in the other three, culminating in the creation of a pyramid-shaped nanostructure of approximately 10 nanometers in size. The first generation of tFNA demonstrates inherent compatibility with biological systems and the ability to permeate cell membrane effectively. These attributes translate into remarkable capabilities for regulating various cellular biological processes, fostering tissue regeneration, and modulating immune responses. The subsequent evolution of tFNA introduces enhanced adaptability and a relatively higher degree of biological stability. This advancement encompasses structural modifications, such as the addition of functional domains at the vertices or side arms, integration of low molecular weight pharmaceuticals, and the implementation of diverse strategies aimed at reversing multi-drug resistance in tumor cells or microorganisms. These augmentations empower tFNA-based systems to be utilized in different scenarios, thus broadening their potential applications in various biomedical fields.
- DNA nanomaterials,
- Tetrahedral framework nucleic acid,
- Drug delivery,
- Antioxidation,
- Immunomodulation,
- Tissue regeneration,
- Antitumor therapy
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沈阳化工大学材料科学与工程学院沈阳 110142