Citation: Han Han, Bi-Te Chen, Jia-Rong Ding, Jin-Ming Si, Tian-Jiao Zhou, Yi Wang, Lei Xing, Hu-Lin Jiang. A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy[J]. Chinese Chemical Letters, ;2024, 35(10): 109583. doi: 10.1016/j.cclet.2024.109583 shu

A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy

Han Han ^{a, 1} ,
Bi-Te Chen ^{a, 1} ,
Jia-Rong Ding ^{c, 1} ,
Jin-Ming Si ^a ,
Tian-Jiao Zhou ^a ,
Yi Wang ^a ,
Lei Xing ^{a, *,} ,
Hu-Lin Jiang ^{a, b, *,}

a.
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
b.
College of Pharmacy, Yanbian University, Yanji 133002, China
c.
Department of Nephrology, Changhai Hospital, Naval Medical University, Shanghai 200433, China

xinglei6xl@163.com

jianghulin3@163.com

Received Date: 29 November 2023
Revised Date: 12 January 2024
Accepted Date: 21 January 2024
Available Online: 1 February 2024

Figures(5)

Activated pancreatic stellate cells (PSCs) are the main source of collagen layer deposition and the key target in pancreatic fibrosis. However, no effective treatment specific to pancreatic fibrosis clinically, owing to the drug accumulation blocked by the collagen barrier and thus it is difficult to inhibit activated PSCs precisely. Herein, a PSCs-targeting nano-system based on “nanodrill” strategy (LA-PC) was designed to enhance the accumulation of all-trans retinoic acid (ATRA) in PSCs, relying on the platelet-derived growth factor receptor beta (PDGFRβ)-targeting peptide (pPB: C*SRNLIDC*) and collagenase (Col). After being injected into fibrotic mice via tail vein, the Col modified on LA-PC can remove the excess collagen layer, and the drug delivery efficiency through pPB targeting peptide was more than 5 times higher than that of free ATRA, as well as the degree of fibrosis significantly reduced. Notably, this nano-system effectively inhibited platelet-derived growth factor subunit B (PDGF-BB)/PDGFRβ axis on PSCs via a down-regulated extracellular signal-regulated protein kinase (ERK) pathway, and accordingly reduced the level of PDGF-BB. Thus, the smart platform provided a promising strategy for the treatment of pancreatic fibrosis to achieve the precise regulation of PSCs.
- Pancreatic fibrosis,
- Pancreatic stellate cells,
- Liposome,
- PDGFRβ,
- pPB peptide
1. [1]
  J. Kirkegård, F.V. Mortensen, D. Cronin-Fenton, Am. J. Gastroenterol. 112 (2017) 1366–1372. doi: 10.1038/ajg.2017.218
2. [2]
  M.S. Petrov, D. Yadav, Nat. Rev. Gastroenterol. Hepatol. 16 (2019) 175–184. doi: 10.1038/s41575-018-0087-5
3. [3]
  V.K. Singh, D. Yadav, P.K. Garg, J. Am. Med. Assoc. 322 (2019) 2422–2434. doi: 10.1001/jama.2019.19411
4. [4]
  P. Mews, P. Phillips, R. Fahmy, et al., Gut 50 (2002) 535–541. doi: 10.1136/gut.50.4.535
5. [5]
  R.G. Wells, J.M. Crawford, Gastroenterology 115 (1998) 491–493. doi: 10.1016/S0016-5085(98)70216-1
6. [6]
  M. Erkan, G. Adler, M.V. Apte, et al., Gut 61 (2012) 172–178. doi: 10.1136/gutjnl-2011-301220
7. [7]
  A. Masamune, T. Watanabe, K. Kikuta, T. Shimosegawa, Clin. Gastroenterol. Hepatol. 7 (2009) S48–S54. doi: 10.1016/j.cgh.2009.07.038
8. [8]
  T. Ji, J. Lang, J. Wang, et al., ACS Nano 11 (2017) 8668–8678. doi: 10.1021/acsnano.7b01026
9. [9]
  J.B. Qiao, Q.Q. Fan, C.L. Zhang, et al., J. Control. Release 321 (2020) 629–640. doi: 10.1016/j.jconrel.2020.02.049
10. [10]
  M.M. Han, X.Y. He, L. Tang, et al., Sci. Adv. 9 (2023) eadg5358. doi: 10.1126/sciadv.adg5358
11. [11]
  L. Qi, H. Han, M.M. Han, et al., Biomaterials 292 (2023) 121945. doi: 10.1016/j.biomaterials.2022.121945
12. [12]
  L.F. Zhang, X.H. Wang, C.L. Zhang, et al., ACS Nano 16 (2022) 14029–14042. doi: 10.1021/acsnano.2c03858
13. [13]
  Q.Q. Fan, C.L. Zhang, J.B. Qiao, et al., Biomaterials 230 (2020) 119616. doi: 10.1016/j.biomaterials.2019.119616
14. [14]
  D. Chakraborty, H. Zhu, A. Jüngel, et al., Sci. Transl. Med. 12 (2020) eaaz5506. doi: 10.1126/scitranslmed.aaz5506
15. [15]
  Z. Xu, W. Luo, L. Chen, et al., Hypertension 79 (2022) 2028–2041. doi: 10.1161/hypertensionaha.122.18657
16. [16]
  C. Betsholtz, Cytokine Growth Factor Rev. 15 (2004) 215–228. doi: 10.1016/j.cytogfr.2004.03.005
17. [17]
  J. Paulsson, T. Sjöblom, P. Micke, et al., Am. J. Pathol. 175 (2009) 334–341. doi: 10.2353/ajpath.2009.081030
18. [18]
  Y.C. Wang, Q. Chen, J.M. Luo, et al., Exp. Mol. Med. 51 (2019) 1–11.
19. [19]
  E. Patsenker, Y. Popov, M. Wiesner, et al., J. Hepatol. 46 (2007) 878–887. doi: 10.1016/j.jhep.2006.11.011
20. [20]
  F. van Dijk, C.M. Hazelhoff, E. Post, et al., Pharmaceutics 12 (2020) 278. doi: 10.3390/pharmaceutics12030278
21. [21]
  J. Zhang, H. Shen, J. Xu, et al., ACS Nano 14 (2020) 6305–6322. doi: 10.1021/acsnano.0c02633
22. [22]
  R. Wang, F.B. Liu, P.P. Chen, et al., Int. J. Biol. Macromol. 235 (2023) 123639. doi: 10.1016/j.ijbiomac.2023.123639
23. [23]
  L. Cai, Z. Gu, J. Zhong, et al., Drug. Discov. Today 23 (2018) 1126–1138. doi: 10.6023/cjoc201709046
24. [24]
  M.Y. Yang, Y.J. Lin, M.M. Han, et al., J. Control. Release 351 (2022) 623–637. doi: 10.1016/j.jconrel.2022.09.054
25. [25]
  X. Ji, Y. Meng, Q. Wang, et al., ACS Nano 17 (2023) 5421–5434. doi: 10.1021/acsnano.2c10042
26. [26]
  Y. Yu, Y. Meng, X. Xu, et al., ACS Nano 17 (2023) 3334–3345. doi: 10.1021/acsnano.2c06313
27. [27]
  L.W.C. Ho, Y. Liu, R. Han, et al., Acc. Chem. Res. 52 (2019) 1519–1530. doi: 10.1021/acs.accounts.9b00103
28. [28]
  Y. Zhao, H. Chen, X. Chen, et al., Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 9 (2017) e1469. doi: 10.1002/wnan.1469
29. [29]
  A.H. Shim, H. Liu, P.J. Focia, et al., Proc. Natl. Acad. Sci. U. S. A. 107 (2010) 11307–11312. doi: 10.1073/pnas.1000806107
30. [30]
  E.J. Battegay, J. Rupp, L. Iruela-Arispe, et al., J. Cell. Biol. 125 (1994) 917–928. doi: 10.1083/jcb.125.4.917
31. [31]
  C.H. Heldin, Cell Commun. Signal. 11 (2013) 97. doi: 10.1186/1478-811X-11-97
32. [32]
  X. Zou, X.Y. Tang, Z.Y. Qu, et al., Int. J. Biol. Macromol. 202 (2022) 539–557. doi: 10.1016/j.ijbiomac.2022.01.113
33. [33]
  R. Jaster, G. Sparmann, J. Emmrich, S. Liebe, Gut 51 (2002) 579–584. doi: 10.1136/gut.51.4.579
34. [34]
  H. Han, L. Xing, B.T. Chen, et al., Adv. Drug Deliv. Rev. 200 (2023) 115051. doi: 10.1016/j.addr.2023.115051
35. [35]
  T.M. Allen, P.R. Cullis, Adv. Drug Deliv. Rev. 65 (2013) 36–48. doi: 10.1016/j.addr.2012.09.037
36. [36]
  S.H. He, T.Y. Hou, J.L. Zhou, et al., Stem Cells Int. 2022 (2022) 2401693.
37. [37]
  M. van der Kroef, T. Carvalheiro, M. Rossato, et al., J. Autoimmun. 111 (2020) 102444. doi: 10.1016/j.jaut.2020.102444
1. [1]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
2. [2]
  Tong Zhang , Chao Sun , Shubin Yang , Zimin Cai , Sifeng Zhu , Wendian Liu , Yun Luan , Cheng Wang . Inhalation of taraxasterol loaded mixed micelles for the treatment of idiopathic pulmonary fibrosis. Chinese Chemical Letters, 2024, 35(8): 109248-. doi: 10.1016/j.cclet.2023.109248
3. [3]
  Rui Wang , He Qi , Haijiao Zheng , Qiong Jia . Light/pH dual-responsive magnetic metal-organic frameworks composites for phosphorylated peptide enrichment. Chinese Chemical Letters, 2024, 35(7): 109215-. doi: 10.1016/j.cclet.2023.109215
4. [4]
  Jianhui Yin , Wenjing Huang , Changyong Guo , Chao Liu , Fei Gao , Honggang Hu . Tryptophan-specific peptide modification through metal-free photoinduced N-H alkylation employing N-aryl glycines. Chinese Chemical Letters, 2024, 35(6): 109244-. doi: 10.1016/j.cclet.2023.109244
5. [5]
  Chuanfeng Fan , Jian Gao , Yingkai Gao , Xintong Yang , Gaoning Li , Xiaochun Wang , Fei Li , Jin Zhou , Haifeng Yu , Yi Huang , Jin Chen , Yingying Shan , Li Chen . A non-peptide-based chymotrypsin-targeted long-wavelength emission fluorescent probe with large Stokes shift and its application in bioimaging. Chinese Chemical Letters, 2024, 35(10): 109838-. doi: 10.1016/j.cclet.2024.109838
6. [6]
  Wenyi Mei , Lijuan Xie , Xiaodong Zhang , Cunjian Shi , Fengzhi Wang , Qiqi Fu , Zhenjiang Zhao , Honglin Li , Yufang Xu , Zhuo Chen . Design, synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells. Chinese Chemical Letters, 2024, 35(5): 108825-. doi: 10.1016/j.cclet.2023.108825
7. [7]
  Tianhao Li , Wenguang Tu , Zhigang Zou . In situ photocatalytically enhanced thermogalvanic cells for electricity and hydrogen production. Chinese Journal of Structural Chemistry, 2024, 43(1): 100195-100195. doi: 10.1016/j.cjsc.2023.100195
8. [8]
  Chen Lu , Zefeng Yu , Jing Cao . Advancement in porphyrin/phthalocyanine compounds-based perovskite solar cells. Chinese Journal of Structural Chemistry, 2024, 43(3): 100240-100240. doi: 10.1016/j.cjsc.2024.100240
9. [9]
  Menglu Guo , Ying-Qi Song , Junfei Cheng , Guoqiang Dong , Xun Sun , Chunquan Sheng . Hydrophobic tagging-induced degradation of NAMPT in leukemia cells. Chinese Chemical Letters, 2024, 35(9): 109392-. doi: 10.1016/j.cclet.2023.109392
10. [10]
  Chi Li , Peng Gao . Is dipole the only thing that matters for inverted perovskite solar cells?. Chinese Journal of Structural Chemistry, 2024, 43(6): 100324-100324. doi: 10.1016/j.cjsc.2024.100324
11. [11]
  Chuan-Zhi Ni , Ruo-Ming Li , Fang-Qi Zhang , Qu-Ao-Wei Li , Yuan-Yuan Zhu , Jie Zeng , Shuang-Xi Gu . A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells. Chinese Chemical Letters, 2024, 35(10): 109862-. doi: 10.1016/j.cclet.2024.109862
12. [12]
  Yuqing Wang , Zhemin Li , Qingjun Lu , Qizhao Li , Jiaxin Luo , Chengjie Li , Yongshu Xie . Solar cells based on doubly concerted companion dyes with the efficiencies modulated by inserting an ethynyl group at different positions. Chinese Chemical Letters, 2024, 35(5): 109093-. doi: 10.1016/j.cclet.2023.109093
13. [13]
  Yaxin Sun , Huiyu Li , Shiquan Guo , Congju Li . Metal-based cathode catalysts for electrocatalytic ORR in microbial fuel cells: A review. Chinese Chemical Letters, 2024, 35(5): 109418-. doi: 10.1016/j.cclet.2023.109418
14. [14]
  Feng Wu , Xuemin Kong , Yixuan Liu , Shuli Wang , Zhong Chen , Xu Hou . Microfluidic-based isolation of circulating tumor cells with high-efficiency and high-purity. Chinese Chemical Letters, 2024, 35(8): 109754-. doi: 10.1016/j.cclet.2024.109754
15. [15]
  Xing Tian , Di Wu , Wanheng Wei , Guifu Dai , Zhanxian Li , Benhua Wang , Mingming Yu . A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death, inflammation and fatty liver tissue. Chinese Chemical Letters, 2024, 35(6): 108912-. doi: 10.1016/j.cclet.2023.108912
16. [16]
  Xin Lu , Haoran Sun , Xiaomeng Li , Chunrui Li , Jinfeng Wang , Dandan Zhou . C14-HSL limits the mycelial morphology of pathogen Trichosporon cells but enhances their aggregation: Mechanisms and implications. Chinese Chemical Letters, 2024, 35(6): 108936-. doi: 10.1016/j.cclet.2023.108936
17. [17]
  Kangrong Yan , Ziqiu Shen , Yanchun Huang , Benfang Niu , Hongzheng Chen , Chang-Zhi Li . Curing the vulnerable heterointerface via organic-inorganic hybrid hole transporting bilayers for efficient inverted perovskite solar cells. Chinese Chemical Letters, 2024, 35(6): 109516-. doi: 10.1016/j.cclet.2024.109516
18. [18]
  Linfang Wang , Jing Liu , Minghao Ren , Wei Guo . A highly sensitive fluorescent HClO probe for discrimination between cancerous and normal cells/tissues. Chinese Chemical Letters, 2024, 35(6): 108945-. doi: 10.1016/j.cclet.2023.108945
19. [19]
  Yan Liu , Yang Wang , Jiayi Zhu , Xuxian Su , Xudong Lin , Liang Xu , Xiwen Xing . Employing pH-responsive RNA triplex to control CRISPR/Cas9-mediated gene manipulation in mammalian cells. Chinese Chemical Letters, 2024, 35(9): 109427-. doi: 10.1016/j.cclet.2023.109427
20. [20]
  Shaonan Liu , Shuixing Dai , Minghua Huang . The impact of ester groups on 1,8-naphthalimide electron transport material in organic solar cells. Chinese Journal of Structural Chemistry, 2024, 43(6): 100277-100277. doi: 10.1016/j.cjsc.2023.100277

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(110)
HTML views(5)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142