Citation: Peizhe Li, Qiaoling Liu, Mengyu Pei, Yuci Gan, Yan Gong, Chuchen Gong, Pei Wang, Mingsong Wang, Xiansong Wang, Da-Peng Yang, Bo Liang, Guangyu Ji. Chlorogenic acid supported strontium polyphenol networks ensemble microneedle patch to promote diabetic wound healing[J]. Chinese Chemical Letters, ;2024, 35(8): 109457. doi: 10.1016/j.cclet.2023.109457 shu

Chlorogenic acid supported strontium polyphenol networks ensemble microneedle patch to promote diabetic wound healing

Peizhe Li ^{a, 1} ,
Qiaoling Liu ^{b, 1} ,
Mengyu Pei ^{d, 1} ,
Yuci Gan ^a ,
Yan Gong ^c ,
Chuchen Gong ^a ,
Pei Wang ^c ,
Mingsong Wang ^c ,
Xiansong Wang ^{c, *,} ,
Da-Peng Yang ^{b, e} ,
Bo Liang ^{b, *,} ,
Guangyu Ji ^{c, *,}

a.
Research Institute of Plastic Surgery, Weifang Medical University, Weifang 261000, China
b.
The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China
c.
Department of Thoracic surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
d.
The Third Affiliated Hospital of Xinxiang Medical University, Institutes of Health Central Plain, Clinical Medical Center of Tissue Engineering and Regeneration, Xinxiang Medical University, Xinxiang 453003, China
e.
School of Rehabilitation Science and Engineering, University of Health and Rehabilitation Sciences, Qingdao 266024, China

wonderluis@sjtu.edu.cn

liangbo@fjmu.edu.cn

jigy_dor@163.com

Received Date: 31 October 2023
Revised Date: 21 December 2023
Accepted Date: 22 December 2023
Available Online: 26 December 2023

Figures(6)

Delayed or non-healing of diabetic wounds is a significant complication, often attributed to high glucose-induced M1 macrophage accumulation, impaired angiogenesis, and reactive oxygen species (ROS) buildup. Addressing this, we introduced a strontium polyphenol network microneedle patch (SrC-MPNs@MN-PP) for percutaneous drug delivery. This patch, formulated with polymer poly(γ-glutamic acid) (γ-PGA) and epsilon-poly-L-lysine (ε-PLL), incorporates strontium polyphenol networks (SrC-MPNs). The release of chlorogenic acid (CGA) from SrC-MPNs not only neutralizes ROS, but strontium ions also foster angiogenesis. Consequently, SrC-MPNs@MN-PP can ameliorate the diabetic wound microenvironment and expedite healing.
- Chlorogenic acid,
- Strontium,
- Microneedle patch,
- Strontium polyphenol network,
- Exudate absorption,
- Diabetic wound healing
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