Citation: Jing Zhang, Charles Wang, Yaoyao Zhang, Haining Xia, Yujuan Wang, Kun Ma, Junfeng Wang. Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine[J]. Chinese Chemical Letters, ;2024, 35(10): 109420. doi: 10.1016/j.cclet.2023.109420 shu

Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine

Jing Zhang ^{a, b} ,
Charles Wang ^c ,
Yaoyao Zhang ^{a, b} ,
Haining Xia ^{a, b} ,
Yujuan Wang ^{a, d} ,
Kun Ma ^{a, d, *,} ,
Junfeng Wang ^{a, b, d}

a.
High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China
b.
University of Science and Technology of China, Hefei 230026, China
c.
University of California, San Diego, La Jolla, CA 92093, United States
d.
International Magnetobiology Frontier Research Center, Hefei 230031, China

makun@hmfl.ac.cn

Received Date: 26 September 2023
Revised Date: 10 November 2023
Accepted Date: 19 December 2023
Available Online: 22 December 2023

Figures(3)

For a significant duration, enhancing the efficacy of cancer therapy has remained a critical concern. Magnetotactic bacteria (MTB), often likened to micro-robots, hold substantial promise as a drug delivery system. MTB, classified as anaerobic, aquatic, and gram-negative microorganisms, exhibit remarkable motility and precise control over their internal biomineralization processes. This unique ability results in the formation of magnetic nanoparticles arranged along filamentous structures in a catenary fashion, enclosed within a membrane. These bacteria possess distinctive biochemical properties that facilitate their precise positioning within complex environments. By harnessing these biochemical attributes, MTB could potentially offer substantial advantages in the realm of cancer therapy. This article reviews the drug delivery capabilities of MTB in tumor treatment and explores various applications based on their inherent properties. The objective is to provide a comprehensive understanding of MTB-driven drug delivery and stimulate innovative insights in this field.
- Magnetotactic bacteria,
- Engineering microrobot,
- Tumor treatment,
- Drug delivery,
- Bioconjugation
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沈阳化工大学材料科学与工程学院沈阳 110142