Citation: Yanjing Li, Jiayin Li, Yuqi Chang, Yunfeng Lin, Lei Sui. Tetrahedral framework nucleic acids promote the proliferation and differentiation potential of diabetic bone marrow mesenchymal stem cell[J]. Chinese Chemical Letters, ;2024, 35(9): 109414. doi: 10.1016/j.cclet.2023.109414 shu

Tetrahedral framework nucleic acids promote the proliferation and differentiation potential of diabetic bone marrow mesenchymal stem cell

Yanjing Li ^a ,
Jiayin Li ^a ,
Yuqi Chang ^a ,
Yunfeng Lin ^{b, *,} ,
Lei Sui ^{a, *,}

a.
Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin 300070, China
b.
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

yunfenglin@scu.edu.cn

suilei@tmu.edu.cn

Received Date: 28 August 2023
Revised Date: 10 December 2023
Accepted Date: 12 December 2023
Available Online: 23 December 2023

Figures(4)

Diabetes mellitus considerably affects bone marrow mesenchymal stem cells (BMSCs), for example, by inhibiting their proliferation and differentiation potential, which enhances the difficulty in endogenous bone regeneration. Hence, effective strategies for enhancing the functions of BMSCs in diabetes have far-reaching consequences for bone healing and regeneration in diabetes patients. Tetrahedral framework nucleic acids (tFNAs) are nucleic acid nanomaterials that can autonomously enter cells and regulate their behaviors. In this study, we evaluated the effects of tFNAs on BMSCs from diabetic rats. We found that tFNAs could promote the proliferation, migration, and osteogenic differentiation of BMSCs from rats with type 2 diabetes mellitus, and inhibited cell senescence and apoptosis. Furthermore, tFNAs effectively scavenged the accumulated reactive oxygen species and activated the suppressed protein kinase B (Akt) signaling pathway. Overall, we show that tFNAs can recover the proliferation and osteogenic potential of diabetic BMSCs by alleviating oxidative stress and activating Akt signaling. The study provides a strategy for endogenous bone regeneration in diabetes and also paves the way for exploiting DNA-based nanomaterials in regenerative medicine.
- Bone marrow mesenchymal stem cell,
- Diabetes mellitus,
- DNA-based nanomaterial,
- Tetrahedral framework nucleic acids,
- Endogenous bone regeneration
1. [1]
  L.C. Hofbauer, B. Busse, R. Eastell, et al., Lancet Diabetes Endocrinol. 10 (2022) 207–220. doi: 10.1016/S2213-8587(21)00347-8
2. [2]
  L.S. Tan, J.T. Chen, L.Y. Lim, et al., Cell Prolif. 55 (2022) e13232. doi: 10.1111/cpr.13232
3. [3]
  N. Jiang, H. Zhao, Y.C. Han, et al., Cell Prolif. 53 (2020) e12909. doi: 10.1111/cpr.12909
4. [4]
  F. Giacco, M. Brownlee, Circ. Res. 107 (2010) 1058–1070. doi: 10.1161/CIRCRESAHA.110.223545
5. [5]
  K. Al-Hezaimi, S. Ramalingam, M. Al-Askar, et al., Int. J. Oral Sci. 8 (2016) 7–15. doi: 10.1038/ijos.2015.34
6. [6]
  M.J. Devine, C.M. Mierisch, E. Jang, et al., J. Orthop. Res. 20 (2002) 1232–1239. doi: 10.1016/S0736-0266(02)00051-7
7. [7]
  T. Ouchi, T. Nakagawa, Regen. Ther. 14 (2020) 72–78. doi: 10.1016/j.reth.2019.12.011
8. [8]
  J. Gao, C. Gao, Cell Prolif. 55 (2022) e13217. doi: 10.1111/cpr.13217
9. [9]
  C.L. Bigarella, R. Liang, S. Ghaffari, Development 141 (2014) 4206–4218. doi: 10.1242/dev.107086
10. [10]
  F. Munmun, P.A. Witt-Enderby, J. Pineal Res. 71 (2021) e12749. doi: 10.1111/jpi.12749
11. [11]
  Y. Sun, Y. Zhu, X. Liu, et al., Cell Prolif. 53 (2020) e12866. doi: 10.1111/cpr.12866
12. [12]
  P.C. Tang, Z.G. Lin, Y. Wang, et al., Chin. Chem. Lett. 21 (2010) 253–256. doi: 10.1016/j.cclet.2009.11.014
13. [13]
  P.F. Xiao, R. Guo, S.Q. Huang, et al., Chin. Chem. Lett. 25 (2014) 673–676. doi: 10.1016/j.cclet.2014.03.047
14. [14]
  R.K. Singh, D.S. Yoon, N. Mandakhbayar, et al., Biomaterials 288 (2022) 121732. doi: 10.1016/j.biomaterials.2022.121732
15. [15]
  Q. Tian, W. Wang, L. Cao, et al., Adv. Mater. 34 (2022) e2207275. doi: 10.1002/adma.202207275
16. [16]
  T. Tian, T. Zhang, S. Shi, et al., Nat. Protoc. 18 (2023) 1028–1055. doi: 10.1038/s41596-022-00791-7
17. [17]
  R.P. Goodman, I.A.T. Schaap, C.F. Tardin, et al., Science 310 (2005) 1661–1665. doi: 10.1126/science.1120367
18. [18]
  S.R. Shi, T.Y. Chen, W.T. Lu, et al., Adv. Funct. Mater. (2023) 2305558.
19. [19]
  T. Zhang, H.S. Ma, X.L. Zhang, et al., Adv. Funct. Mater. 33 (2023) 2213401. doi: 10.1002/adfm.202213401
20. [20]
  L.M. Zhang, L.F. Xu, Y. Wang, et al., Chin. Chem. Lett. 33 (2022) 4089–4095. doi: 10.1016/j.cclet.2022.01.071
21. [21]
  Z.K. Guo, B.J. Jin, Y.L. Fang, et al., Chin. Chem. Lett. 33 (2022) 4208–4212. doi: 10.1016/j.cclet.2022.01.081
22. [22]
  M. Liu, L. Hao, D. Zhao, et al., ACS Appl. Mater. Interfaces 14 (2022) 38506–38514. doi: 10.1021/acsami.2c09462
23. [23]
  S. Shi, Y. Li, T. Zhang, et al., ACS Appl. Mater. Interfaces 13 (2021) 57067–57074. doi: 10.1021/acsami.1c20657
24. [24]
  T.Y. Chen, D.X. Xiao, Y.J. Li, et al., Chin. Chem. Lett. 33 (2022) 2517–2521. doi: 10.1016/j.cclet.2021.11.090
25. [25]
  M. Zhou, N. Liu, Q. Zhang, et al., Cell Prolif. 52 (2019) e12566. doi: 10.1111/cpr.12566
26. [26]
  T. Zhang, T. Tian, Y. Lin, Adv. Mater. 34 (2022) e2107820. doi: 10.1002/adma.202107820
27. [27]
  T. Tian, Y. Li, Y. Lin, Bone Res. 10 (2022) 40. doi: 10.1117/12.2623877
28. [28]
  S. Lin, Q. Zhang, S. Li, et al., ACS Appl. Mater. Interfaces 12 (2020) 11397–11408. doi: 10.1021/acsami.0c00874
29. [29]
  Y. Li, Y. Tang, S. Shi, et al., ACS Appl. Mater. Interfaces 13 (2021) 40354–40364. doi: 10.1021/acsami.1c11468
30. [30]
  H. Peng, M. Yang, Q. Guo, et al., Cell Prolif. 52 (2019) e12624. doi: 10.1111/cpr.12624
31. [31]
  S. Li, T. Tian, Z. Tao, et al., Mater. Today 24 (2018) 57–68.
32. [32]
  Y. Li, S. Gao, S. Shi, et al., Nano-Micro Lett. 13 (2021) 86. doi: 10.1007/s40820-021-00614-6
33. [33]
  S. Shi, J. Xie, J. Zhong, et al., Cell Prolif. 49 (2016) 341–351. doi: 10.1111/cpr.12259
34. [34]
  B. Lecka-Czernik, Diabetologia 60 (2017) 1163–1169. doi: 10.1007/s00125-017-4269-4
35. [35]
  C.E. Murray, C.M. Coleman, Int. J. Mol. Sci. 20 (2019) 4873. doi: 10.3390/ijms20194873
36. [36]
  R.T. Turner, S.P. Kalra, C.P. Wong, et al., J. Bone Miner. Res. 28 (2013) 22–34. doi: 10.1002/jbmr.1734
37. [37]
  T. Zhang, T. Tian, R. Zhou, et al., Nat. Protoc. 15 (2020) 2728–2757. doi: 10.1038/s41596-020-0355-z
38. [38]
  Y. Xie, J.J. He, S.H. Li, et al., Adv. Funct. Mater. 33 (2023) 2303580. doi: 10.1002/adfm.202303580
39. [39]
  R. Yan, W. Cui, W. Ma, et al., ACS Nano 17 (2023) 8767–8781. doi: 10.1021/acsnano.3c02102
40. [40]
  L. Liang, J. Li, Q. Li, et al., Angew. Chem. Int. Ed. 53 (2014) 7745–7750. doi: 10.1002/anie.201403236
41. [41]
  W.C.W. Chan, Z. Tan, M.K.T. To, et al., Int. J. Mol. Sci. 22 (2021) 5445. doi: 10.3390/ijms22115445
42. [42]
  L. Zheng, Q. Tu, S. Meng, et al., J. Cell. Physiol. 232 (2017) 182–191. doi: 10.1002/jcp.25406
43. [43]
  J.M. Ryu, M.Y. Lee, S.P. Yun, et al., J. Cell. Physiol. 224 (2010) 59–70. doi: 10.1002/jcp.22091
44. [44]
  P. Dentelli, C. Barale, G. Togliatto, et al., Diabetologia 56 (2013) 173–184. doi: 10.1007/s00125-012-2734-7
45. [45]
  J. Chen, R. Crawford, C. Chen, et al., Tissue Eng. Part B: Rev. 19 (2013) 516–528. doi: 10.1089/ten.teb.2012.0672
46. [46]
  M. Mahmoud, N. Abu-Shahba, O. Azmy, et al., Stem Cell Rev. Rep. 15 (2019) 194–217. doi: 10.1007/s12015-018-9869-y
47. [47]
  A. Ashkenazi, W.J. Fairbrother, J.D. Leverson, et al., Nat. Rev. Drug Discov. 16 (2017) 273–284. doi: 10.1038/nrd.2016.253
1. [1]
  Xin Zhang , Junyu Chen , Xiang Pei , Linxin Yang , Liang Wang , Luona Chen , Guangmei Yang , Xibo Pei , Qianbing Wan , Jian Wang . Drug-loading ZIF-8 for modification of microporous bone scaffold to promote vascularized bone regeneration. Chinese Chemical Letters, 2024, 35(6): 108889-. doi: 10.1016/j.cclet.2023.108889
2. [2]
  Dexuan Xiao , Tianyu Chen , Tianxu Zhang , Sirong Shi , Mei Zhang , Xin Qin , Yunkun Liu , Longjiang Li , Yunfeng Lin . Transdermal treatment for malignant melanoma by aptamer-modified tetrahedral framework nucleic acid delivery of vemurafenib. Chinese Chemical Letters, 2024, 35(4): 108602-. doi: 10.1016/j.cclet.2023.108602
3. [3]
  Zhe-Han Yang , Jie Yin , Lei Xin , Yuanfang Li , Yijie Huang , Ruo Yuan , Ying Zhuo . Research advancement of DNA-based intelligent hydrogels: Manufacture, characteristics, application of disease diagnosis and treatment. Chinese Chemical Letters, 2024, 35(10): 109558-. doi: 10.1016/j.cclet.2024.109558
4. [4]
  Liangji Chen , Zhen Yuan , Fudong Feng , Xin Zhou , Zhile Xiong , Wuji Wei , Hao Zhang , Banglin Chen , Shengchang Xiang , Zhangjing Zhang . A hydrogen-bonded organic framework containing fluorescent carbazole and responsive pyridyl units for sensing organic acids. Chinese Chemical Letters, 2024, 35(9): 109344-. doi: 10.1016/j.cclet.2023.109344
5. [5]
  Yang Qin , Jiangtian Li , Xuehao Zhang , Kaixuan Wan , Heao Zhang , Feiyang Huang , Limei Wang , Hongxun Wang , Longjie Li , Xianjin Xiao . Toeless and reversible DNA strand displacement based on Hoogsteen-bond triplex. Chinese Chemical Letters, 2024, 35(5): 108826-. doi: 10.1016/j.cclet.2023.108826
6. [6]
  Yunan Yuan , Zhimin Luo , Jie Chen , Chaoliang He , Kai Hao , Huayu Tian . Constructing thermoresponsive PNIPAM-based microcarriers for cell culture and enzyme-free cell harvesting. Chinese Chemical Letters, 2024, 35(7): 109549-. doi: 10.1016/j.cclet.2024.109549
7. [7]
  Chang Liu , Tao Wu , Lijiao Deng , Xuzi Li , Xin Fu , Shuzhen Liao , Wenjie Ma , Guoqiang Zou , Hai Yang . Programmed DNA walkers for biosensors. Chinese Chemical Letters, 2024, 35(9): 109307-. doi: 10.1016/j.cclet.2023.109307
8. [8]
  Lingna Wang , Chenxin Tian , Ruobin Dai , Zhiwei Wang . Eco-friendly regeneration of end-of-life PVDF membrane with triethyl phosphate: Efficiency and mechanism. Chinese Chemical Letters, 2024, 35(9): 109356-. doi: 10.1016/j.cclet.2023.109356
9. [9]
  Tengjia Ni , Xianbiao Hou , Huanlei Wang , Lei Chu , Shuixing Dai , Minghua Huang . Controllable defect engineering based on cobalt metal-organic framework for boosting oxygen evolution reaction. Chinese Journal of Structural Chemistry, 2024, 43(1): 100210-100210. doi: 10.1016/j.cjsc.2023.100210
10. [10]
  Yue Qian , Zhoujia Liu , Haixin Song , Ruize Yin , Hanni Yang , Siyang Li , Weiwei Xiong , Saisai Yuan , Junhao Zhang , Huan Pang . Imide-based covalent organic framework with excellent cyclability as an anode material for lithium-ion battery. Chinese Chemical Letters, 2024, 35(6): 108785-. doi: 10.1016/j.cclet.2023.108785
11. [11]
  Meirong HAN , Xiaoyang WEI , Sisi FENG , Yuting BAI . A zinc-based metal-organic framework for fluorescence detection of trace Cu²⁺. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1603-1614. doi: 10.11862/CJIC.20240150
12. [12]
  Jianqiu Li , Yi Zhang , Songen Liu , Jie Niu , Rong Zhang , Yong Chen , Yu Liu . Cucurbit[8]uril-based non-covalent heterodimer realized NIR cell imaging through topological transformation from nanowire to nanorod. Chinese Chemical Letters, 2024, 35(10): 109645-. doi: 10.1016/j.cclet.2024.109645
13. [13]
  Jing Wang , Zhongliao Wang , Jinfeng Zhang , Kai Dai . Single-layer crystalline triazine-based organic framework photocatalysts with different linking groups for H2O2 production. Chinese Journal of Structural Chemistry, 2023, 42(12): 100202-100202. doi: 10.1016/j.cjsc.2023.100202
14. [14]
  Yuxin Wang , Zhengxuan Song , Yutao Liu , Yang Chen , Jinping Li , Libo Li , Jia Yao . Methyl functionalization of trimesic acid in copper-based metal-organic framework for ammonia colorimetric sensing at high relative humidity. Chinese Chemical Letters, 2024, 35(6): 108779-. doi: 10.1016/j.cclet.2023.108779
15. [15]
  Xuying Yu , Jiarong Mi , Yulan Han , Cai Sun , Mingsheng Wang , Guocong Guo . A stable radiochromic semiconductive viologen-based metal–organic framework for dual-mode direct X-ray detection. Chinese Chemical Letters, 2024, 35(9): 109233-. doi: 10.1016/j.cclet.2023.109233
16. [16]
  Jia-Li Xie , Tian-Jin Xie , Yu-Jie Luo , Kai Mao , Cheng-Zhi Huang , Yuan-Fang Li , Shu-Jun Zhen . Octopus-like DNA nanostructure coupled with graphene oxide enhanced fluorescence anisotropy for hepatitis B virus DNA detection. Chinese Chemical Letters, 2024, 35(6): 109137-. doi: 10.1016/j.cclet.2023.109137
17. [17]
  Benjian Xin , Rui Wang , Lili Liu , Zhiqiang Niu . Metal-organic framework derived MnO@C/CNTs composite for high-rate lithium-based semi-solid flow batteries. Chinese Journal of Structural Chemistry, 2023, 42(11): 100116-100116. doi: 10.1016/j.cjsc.2023.100116
18. [18]
  Jie ZHANG , Xin LIU , Zhixin LI , Yuting PEI , Yuqi YANG , Huimin LI , Zhiqiang LIU . Assembling a luminescence silencing system based on post-synthetic modification strategy: A highly sensitive and selective turn-on metal-organic framework probe for ascorbic acid detection. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 823-833. doi: 10.11862/CJIC.20230310
19. [19]
  Dong-Ling Kuang , Song Chen , Shaoru Chen , Yong-Jie Liao , Ning Li , Lai-Hon Chung , Jun He . 2D Zirconium-based metal-organic framework/bismuth(III) oxide nanorods composite for electrocatalytic CO2-to-formate reduction. Chinese Journal of Structural Chemistry, 2024, 43(7): 100301-100301. doi: 10.1016/j.cjsc.2024.100301
20. [20]
  Chuan-Zhi Ni , Ruo-Ming Li , Fang-Qi Zhang , Qu-Ao-Wei Li , Yuan-Yuan Zhu , Jie Zeng , Shuang-Xi Gu . A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells. Chinese Chemical Letters, 2024, 35(10): 109862-. doi: 10.1016/j.cclet.2024.109862

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(144)
HTML views(7)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142