Citation: Menglu Guo, Ying-Qi Song, Junfei Cheng, Guoqiang Dong, Xun Sun, Chunquan Sheng. Hydrophobic tagging-induced degradation of NAMPT in leukemia cells[J]. Chinese Chemical Letters, ;2024, 35(9): 109392. doi: 10.1016/j.cclet.2023.109392 shu

Hydrophobic tagging-induced degradation of NAMPT in leukemia cells

Menglu Guo ^{a, 1} ,
Ying-Qi Song ^{b, 1} ,
Junfei Cheng ^c ,
Guoqiang Dong ^c ,
Xun Sun ^{a, *,} ,
Chunquan Sheng ^{b, c, *,}

a.
Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China
b.
School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China
c.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China

sunxunf@shmu.edu.cn

shengcq@smmu.edu.cn

Received Date: 4 November 2023
Revised Date: 30 November 2023
Accepted Date: 5 December 2023
Available Online: 12 December 2023

Figures(4)

Nicotinamide phosphoribosyl transferase (NAMPT) is considered as a promising target for cancer therapy to its crucial role in cancer metabolism. Despite the therapeutic potential of NAMPT enzymatic inhibitors, their effectiveness is limited by dose-related toxicity and the inability to suppress nonenzymatic functions of extracellular NAMPT (eNAMPT). Herein, we designed and synthesized the first hydrophobic tagging NAMPT degraders. Among them, compound NH-11 selectively degraded NAMPT in leukemia cells through the ubiquitin-proteasome system. Compound NH-11 effectively induced apoptosis and showed low toxicity to normal cells, representing a promising anti-leukemia lead compound.
- NAMPT,
- Hydrophobic tagging,
- Leukemia,
- Degradation,
- Anti-cancer
1. [1]
  B. Samal, Y. Sun, G. Stearns, et al., Mol. Cell. Biol. 14 (1994) 1431–1437.
2. [2]
  D. Friebe, M. Neef, J. Kratzsch, et al., Diabetologia 54 (2011) 1200–1211. doi: 10.1007/s00125-010-2042-z
3. [3]
  A. Rongvaux, R.J. Shea, M.H. Mulks, et al., Eur. J. Immunol. 32 (2002) 3225–3234. doi: 10.1002/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L
4. [4]
  J.R. Revollo, A.A. Grimm, S. Imai, J. Biol. Chem. 279 (2004) 50754–50763. doi: 10.1074/jbc.M408388200
5. [5]
  A. Garten, S. Schuster, M. Penke, et al., Nat. Rev. Endocrinol. 11 (2015) 535–546. doi: 10.1038/nrendo.2015.117
6. [6]
  V. Audrito, V.G. Messana, S. Deaglio, Front. Oncol. 10 (2020) 358. doi: 10.3389/fonc.2020.00358
7. [7]
  J.S. Kim, C.S. Yoon, D.R. Park, J. Exerc. Nutrit. Biochem. 18 (2014) 259–266. doi: 10.5717/jenb.2014.18.3.259
8. [8]
  R. Manickam, J. Tur, S.L. Badole, et al., J. Cach. Sarcop. Muscle 13 (2022) 1177–1196. doi: 10.1002/jcsm.12887
9. [9]
  S. Imai, L. Guarente, Trends Cell Biol. 24 (2014) 464–471. doi: 10.1016/j.tcb.2014.04.002
10. [10]
  S. Aggarwal, N. Trehanpati, P. Nagarajan, G. Ramakrishna, J. Cell. Physiol. 237 (2022) 3164–3180. doi: 10.1002/jcp.30772
11. [11]
  E. van der Veer, C. Ho, C. O'Neil, et al., J. Biol. Chem. 282 (2007) 10841–10845. doi: 10.1074/jbc.C700018200
12. [12]
  F.F. Sheng, X.P. Dai, J. Qu, et al., Clin. Exp. Pharmacol. Physiol. 38 (2011) 550–554. doi: 10.1111/j.1440-1681.2011.05548.x
13. [13]
  U. Galli, C. Travelli, A. Massarotti, et al., J. Med. Chem. 56 (2013) 6279–6296. doi: 10.1021/jm4001049
14. [14]
  A.A. Grolla, C. Travelli, A.A. Genazzani, J.K. Sethi, Br. J. Pharmacol. 173 (2016) 2182–2194. doi: 10.1111/bph.13505
15. [15]
  S. Torretta, G. Colombo, C. Travelli, et al., Cells 9 (2020) 496. doi: 10.3390/cells9020496
16. [16]
  R. Adya, B.K. Tan, A. Punn, J. Chen, H.S. Randeva, Cardiovasc. Res. 78 (2008) 356–365. doi: 10.1093/cvr/cvm111
17. [17]
  F. Carbone, L. Liberale, A. Bonaventura, et al., Compr. Physiol. 7 (2017) 603–621.
18. [18]
  Y. Wei, H. Xiang, W. Zhang, Front. Pharmacol. 13 (2022) 970553. doi: 10.3389/fphar.2022.970553
19. [19]
  U. Galli, G. Colombo, C. Travelli, et al., Front. Pharmacol. 11 (2020) 656. doi: 10.3389/fphar.2020.00656
20. [20]
  L. Korotchkina, D. Kazyulkin, P.G. Komarov, et al., Leukemia 34 (2020) 1828–1839. doi: 10.1038/s41375-019-0692-5
21. [21]
  K.M. Sakamoto, K.B. Kim, A. Kumagai, et al., Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 8554–8559. doi: 10.1073/pnas.141230798
22. [22]
  Y. Sun, X. Luo, Z. Yang, et al., Chin. Chem. Lett. 34 (2023) 107924. doi: 10.1016/j.cclet.2022.107924
23. [23]
  A. Chen, Y. Zhong, Y. Liu, et al., Chin. Chem. Lett. 34 (2023) 107923. doi: 10.1016/j.cclet.2022.107923
24. [24]
  M. Ao, J. Wu, Y. Cao, et al., Chin. Chem. Lett. 34 (2023) 107741. doi: 10.1016/j.cclet.2022.107741
25. [25]
  T.K. Neklesa, J.D. Winkler, C.M. Crews, Pharmacol. Ther. 174 (2017) 138–144. doi: 10.1016/j.pharmthera.2017.02.027
26. [26]
  G.E. Winter, D.L. Buckley, J. Paulk, et al., Science 348 (2015) 1376–1381. doi: 10.1126/science.aab1433
27. [27]
  S. Xie, F. Zhan, J. Zhu, et al., Angew. Chem. Int. Ed. 62 (2023) e202217246. doi: 10.1002/anie.202217246
28. [28]
  Y. Wang, X. Jiang, F. Feng, W. Liu, H. Sun, Acta Pharm. Sin. B 10 (2020) 207–238. doi: 10.1016/j.apsb.2019.08.001
29. [29]
  L.M. Luh, U. Scheib, K. Juenemann, et al., Angew. Chem. Int. Ed. 59 (2020) 15448–15466. doi: 10.1002/anie.202004310
30. [30]
  Y. Wu, C. Pu, Y. Fu, et al., Acta Pharm. Sin. B 12 (2022) 2859–2868. doi: 10.1016/j.apsb.2021.12.017
31. [31]
  J. Cheng, S. He, J. Xu, et al., J. Med. Chem. 65 (2022) 15725–15737. doi: 10.1021/acs.jmedchem.2c01243
32. [32]
  T.Y. Xu, S.L. Zhang, G.Q. Dong, et al., Sci. Rep. 5 (2015) 10043. doi: 10.1038/srep10043
33. [33]
  G. Dong, W. Chen, X. Wang, et al., J. Med. Chem. 60 (2017) 7965–7983. doi: 10.1021/acs.jmedchem.7b00467
34. [34]
  V. Tolstikov, A. Nikolayev, S. Dong, G. Zhao, M.S. Kuo, PLoS One 9 (2014) e114019. doi: 10.1371/journal.pone.0114019
35. [35]
  C. de Duve, Nat. Cell Biol. 7 (2005) 847–849. doi: 10.1038/ncb0905-847
36. [36]
  I. Dikic, Annu. Rev. Biochem. 86 (2017) 193–224. doi: 10.1146/annurev-biochem-061516-044908
37. [37]
  H.W.S. Tan, B. Anjum, H.M. Shen, et al., Autophagy 15 (2019) 1455–1459. doi: 10.1080/15548627.2019.1609847
38. [38]
  Y. Sun, X. Zhao, N. Ding, et al., Cell Res. 28 (2018) 779–781. doi: 10.1038/s41422-018-0055-1
39. [39]
  K. Raina, J. Lu, Y. Qian, et al., Proc. Natl. Acad. Sci. U. S. A. 113 (2016) 7124–7129. doi: 10.1073/pnas.1521738113
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