Citation: Qi Tan, Run-Zhu Fan, Wencong Yang, Ge Zou, Tao Chen, Jianying Wu, Bo Wang, Sheng Yin, Zhigang She. (+)/(−)-Mycosphatide A, a pair of highly oxidized polyketides with lipid-lowering activity from the mangrove endophytic fungus Mycosphaerella sp. SYSU-DZG01[J]. Chinese Chemical Letters, ;2024, 35(9): 109390. doi: 10.1016/j.cclet.2023.109390 shu

(+)/(−)-Mycosphatide A, a pair of highly oxidized polyketides with lipid-lowering activity from the mangrove endophytic fungus Mycosphaerella sp. SYSU-DZG01

Qi Tan ^a ,
Run-Zhu Fan ^b ,
Wencong Yang ^a ,
Ge Zou ^a ,
Tao Chen ^a ,
Jianying Wu ^a ,
Bo Wang ^a ,
Sheng Yin ^{b, *,} ,
Zhigang She ^{a, *,}

a.
School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China
b.
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

yinsh2@mail.sysu.edu.cn

cesshzhg@mail.sysu.edu.cn

Received Date: 21 October 2023
Revised Date: 4 December 2023
Accepted Date: 6 December 2023
Available Online: 14 December 2023

Figures(6)

(±)-Mycosphatide A (1a/1b), a pair of highly oxidized enantiomeric polyketides featuring a unique 5/5/6/5-fused tetracyclic ring system, were isolated from the mangrove endophytic fungus Mycosphaerella sp. SYSU-DZG01. Their structures were established by extensive spectroscopic analyses, single crystal X-ray diffraction, and experimental electronic circular dichroism (ECD) spectra comparison. The plausible biosynthetic pathway of 1 was proposed, which involved the generation of a key spiro[4.5]decane scaffold. Compounds (+)-1a and (−)-1b exhibited significant lipid-lowering activity in 3T3-L1 adipocytes model, with EC₅₀ values of 7.85 ± 1.56 and 8.87 ± 0.80 µmol/L, respectively.
- Mangrove endophytic fungus,
- Mycosphaerella sp.,
- Polyketide,
- Highly oxidized,
- Lipid-lowering activity
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沈阳化工大学材料科学与工程学院沈阳 110142