Citation: Zhigang Zeng, Changzhou Liao, Lei Yu. Molecules for COVID-19 treatment[J]. Chinese Chemical Letters, ;2024, 35(7): 109349. doi: 10.1016/j.cclet.2023.109349 shu

Molecules for COVID-19 treatment

Zhigang Zeng ^{a, b, *,} ,
Changzhou Liao ^{a, b} ,
Lei Yu ^{c, *,}

a.
Hubei Key Laboratory of Radiation Chemistry and Functional Materials, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437100, China
b.
Hubei Industry Technology Research Institute of Intelligent Health, Xianning 437100, China
c.
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China

Author Bio: Zhigang Zeng is now an associate professor at Hubei University of Science and Technology and a senior research fellow at Hubei Huisheng Pharmaceutical Co., Ltd., China. His current research interest focuses on the drug research and development, organic synthesis methodologies including the related applications in green synthesis, (bio)catalysis

Lei Yu received his B.Sc. from Nanjing University (2003). He received his Ph.D. from Zhejiang University under the direction of academician Xian Huang (2008). He conducted postdoctoral research at Yangzhou University (2008–2011) and Jiangsu Yangnong Chemical Group Company Limited/Nanjing University (2011–2013) respectively. He visited Prof. Mark Lautens' group at the University of Toronto (2013–2014) as a visiting scholar. He is now a professor at Yangzhou University. He is the head of the joint-laboratory of Shanghai Dingya Pharmaceutical Chemical Technology Co., Ltd. with Yangzhou University. He has published over 190 papers and the H-index is currently 43. He obtained over 40 authorized invention patents, including 4 times of assignment of the patent right and one time license for enterprise use; He created economic benefits with an annual output value exceeding 1 billion yuan (ca. ＄ 0.14 billion). His-current research interest is on element chemistry including the related applications on green synthesis, catalysis and novel materials development. For more information, please see the personal homepage at: http://teacher.yzu.edu.cn/YL123/zh_CN/index.htm

zzgang@hbust.edu.cn

yulei@yzu.edu.cn

Received Date: 27 August 2023
Revised Date: 14 November 2023
Accepted Date: 27 November 2023
Available Online: 2 December 2023

Figures(11)

COVID-19 is a major event with worldwide influences. Since the beginning of the epidemic, pharmaceutical chemists have paid attention to the therapeutic effect of a variety of small molecule medicines on COVID-19 infection. A series of organic molecules are designed and found to be effective in the treatment of COVID-19 infection. In fact, no matter how effective they are, with the development of the COVID-19 epidemic, various small molecule medicines are gradually recognized by people. This is equivalent to a good science popularization of pharmaceutical chemistry. This review aims to introduce the molecules for COVID-19 treatment on the basis of their chemical structures, synthetic methods as well as their effects.
- COVID-19,
- Small molecule medicines,
- "Star" drugs,
- Chemical structure,
- Synthetic method
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