Citation: Fengjie Liu, Fansu Meng, Zhenjiang Yang, Huan Wang, Yuehong Ren, Yu Cai, Xingwang Zhang. Exosome-biomimetic nanocarriers for oral drug delivery[J]. Chinese Chemical Letters, ;2024, 35(9): 109335. doi: 10.1016/j.cclet.2023.109335 shu

Exosome-biomimetic nanocarriers for oral drug delivery

Fengjie Liu ^{a, 1} ,
Fansu Meng ^{b, 1} ,
Zhenjiang Yang ^{c, 1} ,
Huan Wang ^a ,
Yuehong Ren ^a ,
Yu Cai ^{a, *,} ,
Xingwang Zhang ^{a, d, *,}

a.
Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 511443, China
b.
Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of TCM, Zhongshan 528400, China
c.
Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China
d.
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 511443, China

yezq@szu.edu.cn

chengm@szu.edu.cn

Received Date: 4 November 2023
Revised Date: 20 November 2023
Accepted Date: 21 November 2023
Available Online: 23 November 2023

Figures(5)

Exosomes as authigenous nanovesicles secreted by living cells represent a significant class of biomaterials. By virtue of their unique roles in intercellular communication, exosomes can mediate intercellular information/cargoes exchange as messenger and facilitate drug delivery as smart vehicles. Oral medication is the most clinically relied upon route of administration and can achieve both topical and systemic therapeutic effects after absorption. Exosomes and exosome-derived vectors have shown to be of high value in oral drug delivery, since they enable efficient oral delivery of therapeutic molecules by targeting intestinal epithelial cells. In recent years, exosome-biomimetic nanocarriers have emerged as an important catalyzer in innovating oral drug delivery systems. In this work, we roundly reviewed the biogenesis and functions of exosomes, their extraction and characterization methods, resources available for exosomes harvest, and design philosophy of exosome-derived vehicles, particularly highlighting the oral delivery application of exosome-biomimetic nanocarriers for diverse medicines. Accumulating evidence suggests that exosome-biomimetic nanocarriers hold great promise for oral delivery of intractable drugs with potential biopharmaceutic issues.
- Exosomes,
- Oral delivery,
- Biomimetic nanocarriers,
- Targeting,
- Bioavailability
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