Citation: Wenjuan Jin, Zelong Chen, Yi Wang, Jiaxuan Li, Jiahui Li, Yuxin Pei, Zhichao Pei. Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy[J]. Chinese Chemical Letters, ;2024, 35(7): 109328. doi: 10.1016/j.cclet.2023.109328 shu

Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy

College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China

peizc@nwafu.edu.cn

Received Date: 28 July 2023
Revised Date: 9 November 2023
Accepted Date: 16 November 2023
Available Online: 25 November 2023

Figures(7)

Chemodynamic therapy (CDT) combined with dual phototherapy (photothermal therapy (PTT) and photodynamic therapy (PDT)) is an efficient way to synergistically improve anti-tumor efficacy. However, the combination of multiple modes often makes the composition of the system more complex, which is not conducive to clinical application. In this study, a dual phototherapy ligand carboxyl-modified Aza-BODIPY (BOD-COOH) and metal active center Cu²⁺ were used to construct multiple-modes metal-photosensitizer nanoparticles (BOD-Cu NPs) via one-step coordination self-assembly for combination therapy of CDT/PDT/PTT. In order to improve delivery efficiency, the targeted hydrophilic molecule pyridine-modified glucose derivative (G-Py) was synthesized and coated onto the BOD-Cu NPs to form a glycosylated nano metal-photosensitizer BOD-Cu@G by electrostatic interaction. The Cu²⁺ in BOD-Cu@G could not only be used as a coordination node for metal-driven self-assembly but also consume intracellular glutathione (GSH), and then catalyze Fenton-like reaction to generate hydroxyl radical (·OH) for CDT. In vitro and in vivo studies revealed that BOD-Cu@G could achieve excellent anti-tumor efficiency by CDT-enhanced dual phototherapy.
- Nano metal-photosensitizer,
- Aza-BODIPY-Cu,
- Coordination self-assembly,
- Chemodynamic therapy,
- Dual phototherapy
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