Citation: Ming Huang, Xiuju Cai, Yan Liu, Zhuofeng Ke. Base-controlled NHC-Ru-catalyzed transfer hydrogenation and α-methylation/transfer hydrogenation of ketones using methanol[J]. Chinese Chemical Letters, ;2024, 35(7): 109323. doi: 10.1016/j.cclet.2023.109323 shu

Base-controlled NHC-Ru-catalyzed transfer hydrogenation and α-methylation/transfer hydrogenation of ketones using methanol

Ming Huang ^a ,
Xiuju Cai ^a ,
Yan Liu ^{c, *,} ,
Zhuofeng Ke ^{b, *,}

a.
School of pharmacy, School of clinical pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
b.
School of Materials Science & Engineering, PCFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
c.
School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China

yanliu@gdut.edu.cn

kezhf3@mail.sysu.edu.cn

Received Date: 5 July 2023
Revised Date: 9 November 2023
Accepted Date: 16 November 2023
Available Online: 19 November 2023

Figures(6)

Herein, we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with methanol. By simply changing the base, a broad range of structurally diverse ketones, could be selectively and efficiently converted to the corresponding β-methylated secondary alcohols or secondary alcohols. Remarkably, this catalytic system was very effective for the synthesis of bio-related molecules and deuterated alcohols, as well as the three-component coupling between methyl ketones, primary alcohols, and methanol. The reaction mechanism was further revealed by experiment and DFT mechanistic investigations.
- Ru complexes,
- Methanol,
- Ketones,
- β-Methylated secondary alcohols,
- Transfer hydrogenation
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