Citation: Chang Liu, Tao Wu, Lijiao Deng, Xuzi Li, Xin Fu, Shuzhen Liao, Wenjie Ma, Guoqiang Zou, Hai Yang. Programmed DNA walkers for biosensors[J]. Chinese Chemical Letters, ;2024, 35(9): 109307. doi: 10.1016/j.cclet.2023.109307 shu

Programmed DNA walkers for biosensors

Chang Liu ^{a, *,} ,
Tao Wu ^a ,
Lijiao Deng ^a ,
Xuzi Li ^a ,
Xin Fu ^a ,
Shuzhen Liao ^a ,
Wenjie Ma ^a ,
Guoqiang Zou ^{b, *,} ,
Hai Yang ^{a, *,}

a.
School of Chemistry and Chemical Engineering, Hunan Institute of Engineering, Xiangtan 411104, China
b.
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China

liuchang202205@163.com

gq-zou@csu.edu.cn

yanghai1001@163.com

Received Date: 21 September 2023
Revised Date: 4 November 2023
Accepted Date: 14 November 2023
Available Online: 17 November 2023

Figures(7)

Nowadays, due to excellent biological and polymeric characteristics, DNA has been widely noted as an emerging building block to construct diverse materials for biosensing, in vivo imaging, drug delivery, and disease therapy. Particularly, relying on programmability, predictability, and stability of DNA, DNA walkers have opened new and exciting opportunities in modern life sciences for target detection and biological analysis, which are constructed by self-assembly of DNA or combining DNA with other nanomaterials (e.g., quantum dots, gold nanoparticles, magnetic nanoparticles, polymers). Compared with conventional nanomaterials (lanthanide-doped upconversion nanoparticles, magnetic nanomaterials, carbon dots, silicon dots, and so on), DNA walkers showed convenient modification, lower biotoxicity, excellent biocompatibility and high biostability, improving the biological application. Meanwhile, with high-speed operating efficiency and sustainable operation, DNA walkers powered by strand displacement reaction or protein enzyme/DNAzyme reaction, have highly sensitive detection and signal amplification abilities, which are applied in biosensing, material assembly and synthesis, and early cancer diagnosis. Worthily, DNA walkers could be regarded as signal amplifiers, which enhanced the signal transduction and amplified biosensor sensing signals. Herein, we systematically and comprehensively summarized the operating principles of various DNA walkers, categorized rational design of the DNA walker, and outlined the application of DNA walker in biosensors. Furthermore, the challenges and future trends of DNA walkers were discussed.
- DNA walker,
- Biosensors,
- Signal amplification strategies,
- Operating principles,
- Design strategies
1. [1]
  J.D. Watson, F.H. Crick, Nature 171 (1953) 737–738. doi: 10.1038/171737a0
2. [2]
  E. Winfree, F. Liu, L.A. Wenzler, N.C. Seeman, Nature 394 (1998) 539–544. doi: 10.1038/28998
3. [3]
  C.H. Lu, B. Willner, I. Willner, ACS Nano 7 (2013) 8320–8332. doi: 10.1021/nn404613v
4. [4]
  N.C. Seeman, Nature 421 (2003) 427–431. doi: 10.1038/nature01406
5. [5]
  E. National Academies of Sciences and MedicineTriennial Review of the National Nanotechnology Initiative, National Academies Press, 2017.
6. [6]
  Q. Hu, H. Li, L. Wang, H. Gu, C. Fan, Chem. Rev. 119 (2018) 6459–6506.
7. [7]
  Y. Hu, C.M. Niemeyer, Adv. Mater. 31 (2019) 1806294. doi: 10.1002/adma.201806294
8. [8]
  N.C. Seeman, H.F. Sleiman, Nat. Rev. Mater. 3 (2017) 1–23. doi: 10.5498/wjp.v7.i1.1
9. [9]
  A.J. Thubagere, W. Li, R.F. Johnson, et al., Science 357 (2017) eaan6558. doi: 10.1126/science.aan6558
10. [10]
  X. Yang, Y. Tang, S.D. Mason, J. Chen, F. Li, ACS Nano 10 (2016) 2324–2330. doi: 10.1021/acsnano.5b07102
11. [11]
  H. Zhang, M. Lai, A. Zuehlke, et al., Angew. Chem. 127 (2015) 14534–14538. doi: 10.1002/ange.201506312
12. [12]
  C. Jung, P.B. Allen, A.D. Ellington, Nat. Nanotechnol. 11 (2016) 157–163. doi: 10.1038/nnano.2015.246
13. [13]
  L. Song, Y. Zhuge, X. Zuo, M. Li, F. Wang, Adv. Sci. 9 (2022) 2200327. doi: 10.1002/advs.202200327
14. [14]
  J. Zhao, H. Chu, Y. Zhao, Y. Lu, L. Li, J. Am. Chem. Soc. 141 (2019) 7056–7062. doi: 10.1021/jacs.9b01931
15. [15]
  P.W. Rothemund, Nature 440 (2006) 297–302. doi: 10.1038/nature04586
16. [16]
  A. Kuzuya, Y. Ohya, Acc. Chem. Res. 47 (2014) 1742–1749. doi: 10.1021/ar400328v
17. [17]
  Y. Suzuki, M. Endo, Y. Yang, H. Sugiyama, J. Am. Chem. Soc. 136 (2014) 1714–1717. doi: 10.1021/ja4109819
18. [18]
  J.I. Cutler, E. Auyeung, C.A. Mirkin, J. Am. Chem. Soc. 134 (2012) 1376–1391. doi: 10.1021/ja209351u
19. [19]
  C.A. Mirkin, R.L. Letsinger, R.C. Mucic, J.J. Storhoff, Nature 382 (1996) 607–609. doi: 10.1038/382607a0
20. [20]
  Y. Dong, C. Yao, Y. Zhu, et al., Chem. Rev. 120 (2020) 9420–9481. doi: 10.1021/acs.chemrev.0c00294
21. [21]
  Y. Hu, Z. Chen, H. Zhang, et al., Drug Deliv. 24 (2017) 1295–1301. doi: 10.1080/10717544.2017.1373166
22. [22]
  Q. Liu, D. Wang, Z. Xu, et al., Chem. Bio. Chem. 20 (2019) 1139–1144. doi: 10.1002/cbic.201800761
23. [23]
  Y. Ma, Z. Wang, Y. Ma, et al., Angew. Chem. 130 (2018) 5487–5491. doi: 10.1002/ange.201801195
24. [24]
  N. Xie, H. Wang, K. Quan, et al., TrAC Trend. Anal. Chem. 126 (2020) 115844. doi: 10.1016/j.trac.2020.115844
25. [25]
  S. Dey, C. Fan, K.V. Gothelf, et al., Nat. Rev. Meth. Prim. 1 (2021) 13. doi: 10.1038/s43586-020-00009-8
26. [26]
  B. Saccà, C.M. Niemeyer, Angew. Chem. Int. Ed. 51 (2012) 58–66. doi: 10.1002/anie.201105846
27. [27]
  L. Zhou, M. Gao, W. Fu, et al., Sci. Adv. 6 (2020) eabb0695. doi: 10.1126/sciadv.abb0695
28. [28]
  A. Patino Diaz, S. Bracaglia, S. Ranallo, et al., J. Am. Chem. Soc. 144 (2022) 5820–5826. doi: 10.1021/jacs.1c11706
29. [29]
  M.R. Cui, Y. Chen, D. Zhu, J. Chao, Anal. Chem. 94 (2022) 10874–10884. doi: 10.1021/acs.analchem.2c02299
30. [30]
  H. Wang, J. Zeng, J. Huang, et al., Angew. Chem. Int. Ed. 61 (2022) e202116932. doi: 10.1002/anie.202116932
31. [31]
  T. Yao, L. Kong, Y. Liu, et al., Anal. Chem. 94 (2022) 12256–12262. doi: 10.1021/acs.analchem.2c03083
32. [32]
  Y. Chen, M. Wang, C. Mao, Angew. Chem. 116 (2004) 3638–3641. doi: 10.1002/ange.200453779
33. [33]
  S. Mohapatra, C.T. Lin, X.A. Feng, A. Basu, T. Ha, Chem. Rev. 120 (2019) 36–78.
34. [34]
  W. Sun, Nat. Nanotech. 12 (2017) 1120 1120.
35. [35]
  J.S. Shin, N.A. Pierce, J. Am. Chem. Soc. 126 (2004) 10834–10835. doi: 10.1021/ja047543j
36. [36]
  S.F. Wickham, J. Bath, Y. Katsuda, et al., Nat. Nanotech. 7 (2012) 169–173. doi: 10.1038/nnano.2011.253
37. [37]
  S. Yu, Y. Zhou, Y. Sun, et al., Angew. Chem. Int. Ed. 60 (2021) 5948–5958. doi: 10.1002/anie.202012801
38. [38]
  T.G. Cha, J. Pan, H. Chen, et al., J. Am. Chem. Soc. 137 (2015) 9429–9437. doi: 10.1021/jacs.5b05522
39. [39]
  K. Lund, A.J. Manzo, N. Dabby, et al., Nature 465 (2010) 206–210. doi: 10.1038/nature09012
40. [40]
  D. Wang, C. Vietz, T. Schröder, et al., Nano Lett. 17 (2017) 5368–5374. doi: 10.1021/acs.nanolett.7b01829
41. [41]
  X. Qu, D. Zhu, G. Yao, et al., Angew. Chem. 129 (2017) 1881–1884. doi: 10.1002/ange.201611777
42. [42]
  J. Chen, Z. Luo, C. Sun, et al., TrAC Trends Anal. Chem. 120 (2019) 115626. doi: 10.1016/j.trac.2019.115626
43. [43]
  Z.G. Wang, J. Elbaz, I. Willner, Nano Lett. 11 (2011) 304–309. doi: 10.1021/nl104088s
44. [44]
  M. Xu, D. Tang, Anal. Chim. Acta 1171 (2021) 338523. doi: 10.1016/j.aca.2021.338523
45. [45]
  J. Li, C. Fan, H. Pei, J. Shi, Q. Huang, Adv. Mater. 25 (2013) 4386–4396. doi: 10.1002/adma.201300875
46. [46]
  X. Liu, C.H. Lu, I. Willner, Acc. Chem. Res. 47 (2014) 1673–1680. doi: 10.1021/ar400316h
47. [47]
  M. Škugor, J. Valero, K. Murayama, et al., Angew. Chem. Int. Ed. 58 (2019) 6948–6951. doi: 10.1002/anie.201901272
48. [48]
  M. Oishi, K. Saito, ACS Nano 14 (2020) 3477–3489. doi: 10.1021/acsnano.9b09581
49. [49]
  H. Pang, X. Xu, W. Jiang, Sensor. Actuat. B: Chem. 314 (2020) 128053. doi: 10.1016/j.snb.2020.128053
50. [50]
  D. Wang, P. Liu, D. Luo, Angew. Chem. 134 (2022) e202110666. doi: 10.1002/ange.202110666
51. [51]
  D. Li, W. Zhou, R. Yuan, Y. Xiang, Anal. Chem. 89 (2017) 9934–9940. doi: 10.1021/acs.analchem.7b02247
52. [52]
  C. Jung, P.B. Allen, A.D. Ellington, ACS Nano 11 (2017) 8047–8054. doi: 10.1021/acsnano.7b02693
53. [53]
  D. Li, Z. Luo, H. An, et al., Talanta 217 (2020) 121056. doi: 10.1016/j.talanta.2020.121056
54. [54]
  Y. Yu, W.S. Zhang, Y. Guo, et al., Biosens. Bioelectron. 167 (2020) 112482. doi: 10.1016/j.bios.2020.112482
55. [55]
  K. Chen, Q. Huang, T. Fu, et al., Anal. Chem. 92 (2020) 7404–7408. doi: 10.1021/acs.analchem.0c01134
56. [56]
  Y. Yao, D. Zhao, N. Li, et al., Anal. Chem 91 (2019) 7850–7857. doi: 10.1021/acs.analchem.9b01591
57. [57]
  Y. Xu, K.D. Lunnen, H. Kong, Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 12990–12995. doi: 10.1073/pnas.241215698
58. [58]
  N. Hu, Y. Wang, C. Liu, et al., Chem. Commun. 56 (2020) 639–642. doi: 10.1039/c9cc08692g
59. [59]
  X.M. Zhou, Y. Zhuo, T.T. Tu, R. Yuan, Y.Q. Chai, Anal. Chem. 94 (2022) 8732–8739. doi: 10.1021/acs.analchem.2c01171
60. [60]
  H. Peng, X.F. Li, H. Zhang, X.C. Le, Nat. Commun. 8 (2017) 14378. doi: 10.1038/ncomms14378
61. [61]
  H. Nakao, M. Gad, S. Sugiyama, K. Otobe, T. Ohtani, J. Am. Chem. Soc. 125 (2003) 7162–7163. doi: 10.1021/ja034185w
62. [62]
  D.Y. Zhang, R.F. Hariadi, H.M. Choi, E. Winfree, Nat. Commun. 4 (2013) 1965. doi: 10.1038/ncomms2965
63. [63]
  T.E. Tomov, R. Tsukanov, Y. Glick, et al., ACS Nano 11 (2017) 4002–4008. doi: 10.1021/acsnano.7b00547
64. [64]
  Y. Yang, M.A. Goetzfried, K. Hidaka, et al., Nano Lett. 15 (2015) 6672–6676. doi: 10.1021/acs.nanolett.5b02502
65. [65]
  L. Liu, Y. Zhang, R. Yuan, H. Wang, Anal. Chem. 92 (2020) 15112–15119. doi: 10.1021/acs.analchem.0c03311
66. [66]
  H. Zhou, J. Zhang, B. Li, et al., Anal. Chem. 93 (2021) 6120–6127. doi: 10.1021/acs.analchem.0c05221
67. [67]
  Z. Xu, Y. Chang, Y. Chai, H. Wang, R. Yuan, Anal. Chem. 91 (2019) 4883–4888. doi: 10.1021/acs.analchem.9b00728
68. [68]
  C. Zhou, X. Duan, N. Liu, Nat. Commun. 6 (2015) 8102. doi: 10.1038/ncomms9102
69. [69]
  C.Y. Li, J.X. Liu, L. Yuheng, et al., Anal. Chem. 94 (2022) 5450–5459. doi: 10.1021/acs.analchem.2c00830
70. [70]
  L. Yang, J. Fang, J. Li, et al., Anal. Chim. Acta 1143 (2021) 157–165. doi: 10.1016/j.aca.2020.11.043
71. [71]
  C. Liu, Y. Hu, Q. Pan, et al., Biosens. Bioelectron. 136 (2019) 31–37. doi: 10.1016/j.bios.2019.04.031
72. [72]
  Y. Qi, Y. Zhai, W. Fan, et al., Anal. Chem. 93 (2021) 1620–1626. doi: 10.1021/acs.analchem.0c04073
73. [73]
  Q.M. Feng, P. Ma, Q.H. Cao, Y.H. Guo, J.J. Xu, Chem. Commun. 56 (2020) 269–272. doi: 10.1039/c9cc08051a
74. [74]
  Y. Chang, S. Xu, Y. Li, et al., Anal. Chem. 93 (2021) 12981–12986. doi: 10.1021/acs.analchem.1c02668
75. [75]
  T. Bao, R. Fu, Y. Jiang, et al., Anal. Chem. 93 (2021) 13475–13484. doi: 10.1021/acs.analchem.1c02125
76. [76]
  S. Wang, Y. Ji, H. Fu, H. Ju, J. Lei, Analyst 144 (2019) 691–697. doi: 10.1039/c8an01892h
77. [77]
  H. Chai, P. Miao, Anal. Chem. 91 (2019) 4953–4957. doi: 10.1021/acs.analchem.9b01118
78. [78]
  P.S. Kwon, S. Ren, S.J. Kwon, et al., Nat. Chem. 12 (2020) 26–35. doi: 10.1038/s41557-019-0369-8
79. [79]
  H. Ijäs, I. Hakaste, B. Shen, M.A. Kostiainen, V. Linko, ACS Nano 13 (2019) 5959–5967. doi: 10.1021/acsnano.9b01857
80. [80]
  J. Huang, L. Zhu, H. Ju, J. Lei, Anal. Chem. 91 (2019) 6981–6985. doi: 10.1021/acs.analchem.9b01603
81. [81]
  C. Liu, Y. Hu, Q. Pan, et al., Chem. Commun. 56 (2020) 3496–3499. doi: 10.1039/d0cc00017e
82. [82]
  Y. Gao, S. Zhang, C. Wu, et al., ACS Nano 15 (2021) 19211–19224. doi: 10.1021/acsnano.1c04260
83. [83]
  N. Wang, Y.J. Jiang, X. Zhang, et al., Analyst 146 (2021) 1675–1681. doi: 10.1039/d0an02289f
84. [84]
  X. Qu, J. Wang, R. Zhang, et al., Microchim. Acta 187 (2020) 1–8. doi: 10.1007/s00604-019-3921-8
85. [85]
  M. Ye, Y. Kong, C. Zhang, et al., ACS Nano 15 (2021) 14253–14262. doi: 10.1021/acsnano.1c02229
86. [86]
  K. Yang, H. Wang, N. Ma, et al., ACS Appl. Mater. Interfaces 10 (2018) 44546–44553. doi: 10.1021/acsami.8b16408
87. [87]
  E. Yang, D. Li, P. Yin, et al., Biosens. Bioelectron 172 (2021) 112758. doi: 10.1016/j.bios.2020.112758
88. [88]
  C. Wang, R. Liu, J. Hu, Y. Lv, Chem. Eur. J. 25 (2019) 12270–12274. doi: 10.1002/chem.201903034
89. [89]
  L. Wang, Z.J. Liu, H.X. Cao, G.X. Liang, Sensor. Actuat. B: Chem. 337 (2021) 129813. doi: 10.1016/j.snb.2021.129813
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2. [2]
  Yang Qin , Jiangtian Li , Xuehao Zhang , Kaixuan Wan , Heao Zhang , Feiyang Huang , Limei Wang , Hongxun Wang , Longjie Li , Xianjin Xiao . Toeless and reversible DNA strand displacement based on Hoogsteen-bond triplex. Chinese Chemical Letters, 2024, 35(5): 108826-. doi: 10.1016/j.cclet.2023.108826
3. [3]
  Gaojian Yang , Zhiyang Li , Rabia Usman , Zhu Chen , Yuan Liu , Song Li , Hui Chen , Yan Deng , Yile Fang , Nongyue He . DNA walker induced "signal on" fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer. Chinese Chemical Letters, 2025, 36(2): 109930-. doi: 10.1016/j.cclet.2024.109930
4. [4]
  Tianyu Sun , Zhoujun Dong , Paul Michael Malugulu , Tengfei Zhen , Lei Wang , Yao Chen , Haopeng Sun . Advances in design strategies and imaging applications of specific butyrylcholinesterase probes. Chinese Chemical Letters, 2025, 36(7): 110451-. doi: 10.1016/j.cclet.2024.110451
5. [5]
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