Citation: Ji Liu, Dongsheng He, Tianjiao Hao, Yumin Hu, Yan Zhao, Zhen Li, Chang Liu, Daquan Chen, Qiyue Wang, Xiaofei Xin, Yan Shen. Gold mineralized "hybrid nanozyme bomb" for NIR-II triggered tumor effective permeation and cocktail therapy[J]. Chinese Chemical Letters, ;2024, 35(9): 109296. doi: 10.1016/j.cclet.2023.109296 shu

Gold mineralized "hybrid nanozyme bomb" for NIR-II triggered tumor effective permeation and cocktail therapy

Ji Liu ^{a, 1} ,
Dongsheng He ^{a, 1} ,
Tianjiao Hao ^{a, 1} ,
Yumin Hu ^b ,
Yan Zhao ^c ,
Zhen Li ^a ,
Chang Liu ^a ,
Daquan Chen ^{d, *,} ,
Qiyue Wang ^{e, *,} ,
Xiaofei Xin ^{a, *,} ,
Yan Shen ^{a, *,}

a.
Department of Pharmaceutics, State Key Laboratory of Nature Medicines, China Pharmaceutical University, Nanjing 210009, China
b.
Wuxi Hequan Pharmaceutical Co., Ltd., Wuxi 214029, China
c.
Beijing Xinghao Yingsheng Pharmaceutical Co., Ltd., Beijing 102609, China
d.
School of Pharmacy, Yantai University, Yantai 264005, China
e.
School of Pharmaceutical Science, Nanjing Tech University, Nanjing 211816, China

cdq1981@126.com

qiyue.wang@njtech.edu.cn

xxin@cpu.edu.cn

shenyan@cpu.edu.cn

Received Date: 4 September 2023
Revised Date: 5 November 2023
Accepted Date: 8 November 2023
Available Online: 11 November 2023

Figures(5)

Lung cancer is one of the most common malignant tumors with the fastest increase in the incidence rate and mortality. Even after maximum tumor resection assistance with a radiotherapy and chemotherapy combination, the recurrence of non-small cell lung cancer is still inevitable. In addition, low targeting efficiency and poor permeability of drug delivery systems strongly affect the therapeutic efficiency of anti-cancer drugs on non-small cell lung cancer. Here we designed a gemcitabine (GEM) loaded arginine-glycine-aspartic acid-cysteine (RGDc)-modified gold mineralization "hybrid nanozyme bomb" (RGTG) to overcome those obstacles. RGDc modification improved the active targeting of liposomes to the tumor tissues with the second near-infrared (NIR-II)-triggered gold-shell disruption and GEM release. The collapsed gold-shell particles with a smaller size could penetrate the tumor solid barrier and act as photothermal therapy (PTT) agents to improve PTT therapy and starvation therapy via generating gluconic acid and reactive oxygen species (ROS). Moreover, the resting reversal effect of gold particles on tumor fibroblasts can achieve accelerating tumor penetration of gold particles and GEM. Compared to monotherapy, RGTG showed significant improvement in tumor inhibition, with a tumor volume reduction of 83% compared to the control group, which provides a promising tumor treatment platform for non-small cell lung cancer (NSCLC).
- Gold mineralized,
- Hybrid nanozyme bomb,
- Starvation therapy,
- Cocktail therapy,
- NSCLC
1. [1]
  H. Sung, J. Ferlay, R.L. Siegel, et al., CA Cancer J. Clin. 71 (2021) 209–249. doi: 10.3322/caac.21660
2. [2]
  S.K. Alam, L. Wang, Z. Zhu, L.H. Hoeppner, NPJ Precis. Oncol. 7 (2023) 33. doi: 10.1038/s41698-023-00370-3
3. [3]
  S. Garinet, P. Wang, A. Mansuet-Lupo, et al., Cancers 14 (2022) 1400. doi: 10.3390/cancers14061400
4. [4]
  J. Vansteenkiste, E. Wauters, B. Reymen, et al., Annals Oncol. 30 (2019) 1244–1253. doi: 10.1093/annonc/mdz175
5. [5]
  M. You, Z. Xie, N. Zhang, et al., Signal Transduc. Target. Ther. 8 (2023) 196. doi: 10.1038/s41392-023-01442-3
6. [6]
  J. Li, D. Tong, J. Lin, J. Zhejiang Univ. 51 (2022) 241–250. doi: 10.3724/zdxbyxb-2021-0297
7. [7]
  X. Fan, Z. Luo, Y. Chen, et al., Acta Biomater. 142 (2022) 274–283. doi: 10.1016/j.actbio.2022.01.056
8. [8]
  M. Wang, M. Chang, P. Zheng, et al., Adv. Sci. 9 (2022) e2202332.
9. [9]
  Y. Xu, S.Y. Liu, L. Zeng, et al., Adv. Mater. 34 (2022) e2204733.
10. [10]
  Z. Ding, D. Wang, W. Shi, et al., Int. J. Nanomed. 15 (2020) 8383–8400. doi: 10.2147/IJN.S272495
11. [11]
  L. Zhou, J. Jiang, Z. Huang, et al., Mol. Cancer 21 (2022) 168. doi: 10.1186/s12943-022-01638-1
12. [12]
  W. Wang, X. Liu, X. Zheng, et al., Adv. Healthc. Mater. 9 (2020) e2001117.
13. [13]
  K. Kawasaki, A.V. Buchanan, K.M. Weiss, Ann. Rev. Genet. 43 (2009) 119–142. doi: 10.1146/annurev-genet-102108-134242
14. [14]
  P. Srivastava, S.K. Hira, D.N. Srivastava, et al., ACS Appl. Mater. Interfaces 10 (2018) 6917–6929. doi: 10.1021/acsami.7b18729
15. [15]
  S. Yao, B. Jin, Z. Liu, et al., Adv. Mater. 29 (2017) 1605903. doi: 10.1002/adma.201605903
16. [16]
  S. Qing, C. Lyu, L. Zhu, et al., Adv. Mater. 32 (2020) e2002085.
17. [17]
  Z. Jiang, Y. Liu, R. Shi, et al., Adv. Mater. 34 (2022) e2110094.
18. [18]
  Y. Hu, H. Cheng, X. Zhao, et al., ACS Nano 11 (2017) 5558–5566. doi: 10.1021/acsnano.7b00905
19. [19]
  Z. Zhang, L.M. Bragg, M.R. Servos, J. Liu, Chin. Chem. Lett. 30 (2019) 1655–1658. doi: 10.1016/j.cclet.2019.05.062
20. [20]
  L.H. Fu, C. Qi, J. Lin, P. Huang, Chem. Soc. Rev. 47 (2018) 6454–6472. doi: 10.1039/C7CS00891K
21. [21]
  H. Dai, Q. Fan, C. Wang, Exploration 2 (2022) 20210157. doi: 10.1002/EXP.20210157
22. [22]
  M. Zhao, R. Wang, K. Yang, et al., Acta Pharm. Sin. B 13 (2023) 916–941. doi: 10.1016/j.apsb.2022.10.019
23. [23]
  H. Zhang, P. Xu, X. Zhang, et al., Chin. Chem. Lett. 31 (2020) 1083–1086. doi: 10.1016/j.cclet.2019.10.005
24. [24]
  B. Chen, L. Mei, R. Fan, et al., Chin. Chem. Lett. 32 (2021) 1775–1779. doi: 10.1016/j.cclet.2020.12.058
25. [25]
  P. Zheng, J. Ding, Asian J. Pharm. Sci. 17 (2022) 1–3. doi: 10.1016/j.ajps.2021.10.004
26. [26]
  P. Zheng, B. Ding, R. Shi, et al., Adv. Mater. 33 (2021) e2007426.
27. [27]
  X. Xue, H. Qu, Y. Li, Exploration 2 (2022) 20210134. doi: 10.1002/EXP.20210134
28. [28]
  Y. Li, W. Song, Y. Hu, et al., J. Nanobiotechnol. 19 (2021) 293. doi: 10.1186/s12951-021-01004-1
29. [29]
  W. Luo, C. Zhu, S. Su, et al., ACS Nano 4 (2010) 7451–7458. doi: 10.1021/nn102592h
30. [30]
  S. Wang, W. Chen, A.L. Liu, et al., ChemPhysChem 13 (2012) 1199–1204. doi: 10.1002/cphc.201100906
31. [31]
  B. Sampadi, S. Vermeulen, B. Mišovic, et al., Cells 11 (2022) 3794. doi: 10.3390/cells11233794
32. [32]
  A. Huwaidi, B. Kumari, G. Robert, et al., J. Phys. Chem. Lett. 12 (2021) 9947–9954. doi: 10.1021/acs.jpclett.1c02598
33. [33]
  X.L. Cheng, T.R. Fu, D.F. Zhang, et al., Anal. Biochem. 667 (2023) 115087. doi: 10.1016/j.ab.2023.115087
34. [34]
  L. Ronchetti, E. Melucci, F. De Nicola, et al., Int. J. Cancer 140 (2017) 2587–2595. doi: 10.1002/ijc.30668
35. [35]
  Y. Yin, W.W. Zhu, L.P. Guo, et al., J. Phys. Chem. B 117 (2013) 125–131. doi: 10.1021/jp3092804
36. [36]
  Y. Liu, Z. Ye, W. Yang, et al., J. Control. Release 345 (2022) 120–137. doi: 10.1016/j.jconrel.2022.03.010
37. [37]
  Q. Zhou, J. Li, J. Xiang, et al., Adv. Drug Deliv. Rev. 189 (2022) 114480. doi: 10.1016/j.addr.2022.114480
38. [38]
  Y. Zhang, S. Zhang, Z. Zhang, et al., Front. Chem. 9 (2021) 728066. doi: 10.3389/fchem.2021.728066
39. [39]
  S. Jiang, J. Lin, P. Huang, Adv. Healthc. Mater. 12 (2022) e2202208.
40. [40]
  C. Hu, M. Niestroj, D. Yuan, et al., Int. J. Nanomedicine 10 (2015) 2065–2077.
1. [1]
  Linjie Ju , Zhongxi Huang , Qian Shen , Chan Fu , Shuanghe Li , Wenjie Duan , Chenfeng Xu , Weizhen An , Zhiqiang Zhai , Jifu Wei , Changmin Yu , Guoren Zhou . Glutathione depletion based Pt(Ⅳ) hybrid mesoporous organosilica delivery system to conquer cisplatin chemoresistance: A “one stone three birds” strategy. Chinese Chemical Letters, 2024, 35(10): 109450-. doi: 10.1016/j.cclet.2023.109450
2. [2]
  Han Han , Bi-Te Chen , Jia-Rong Ding , Jin-Ming Si , Tian-Jiao Zhou , Yi Wang , Lei Xing , Hu-Lin Jiang . A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy. Chinese Chemical Letters, 2024, 35(10): 109583-. doi: 10.1016/j.cclet.2024.109583
3. [3]
  Ling Yang , Min Ren , Jie Wang , Liming He , Shanshan Wu , Shuai Yang , Wei Zhao , Hao Cheng , Xiaoming Zhou , Maling Gou . A non-viral gene therapy for melanoma by staphylococcal enterotoxin A. Chinese Chemical Letters, 2024, 35(5): 108822-. doi: 10.1016/j.cclet.2023.108822
4. [4]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
5. [5]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
6. [6]
  Tao LIU , Yuting TIAN , Ke GAO , Xuwei HAN , Ru'nan MIN , Wenjing ZHAO , Xueyi SUN , Caixia YIN . A photothermal agent with high photothermal conversion efficiency and high stability for tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1622-1632. doi: 10.11862/CJIC.20240107
7. [7]
  Bohan Chen , Liming Gong , Jing Feng , Mingji Jin , Liqing Chen , Zhonggao Gao , Wei Huang . Research advances of nanoparticles for CAR-T therapy in solid tumors. Chinese Chemical Letters, 2024, 35(9): 109432-. doi: 10.1016/j.cclet.2023.109432
8. [8]
  Fengyun Li , Zerong Pei , Shuting Chen , Gen li , Mengyang Liu , Liqin Ding , Jingbo Liu , Feng Qiu . Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid. Chinese Chemical Letters, 2024, 35(5): 108752-. doi: 10.1016/j.cclet.2023.108752
9. [9]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
10. [10]
  Zhe Li , Ping-Zhao Liang , Li Xu , Fei-Yu Yang , Tian-Bing Ren , Lin Yuan , Xia Yin , Xiao-Bing Zhang . Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy. Chinese Chemical Letters, 2024, 35(8): 109190-. doi: 10.1016/j.cclet.2023.109190
11. [11]
  Huijiao Fu , Peiqin Liang , Qianwen Chen , Yan Wang , Guang Li , Xuzi Cai , Shengtao Wang , Kun Chen , Shengying Shi , Zhiqiang Yu , Xuefeng Wang . COX-2 blocking therapy in cisplatin chemosensitization of ovarian cancer: An allicin-based nanomedicine approach. Chinese Chemical Letters, 2024, 35(8): 109241-. doi: 10.1016/j.cclet.2023.109241
12. [12]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
13. [13]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
14. [14]
  An Lu , Yuhao Guo , Yi Yan , Lin Zhai , Xiangyu Wang , Weiran Cao , Zijie Li , Zhixia Zhao , Yujie Shi , Yuanjun Zhu , Xiaoyan Liu , Huining He , Zhiyu Wang , Jian-Cheng Wang . Nanomedicine integrating the lipidic derivative of 5-fluorouracil, miriplatin and PD-L1 siRNA for enhancing tumor therapy. Chinese Chemical Letters, 2024, 35(6): 108928-. doi: 10.1016/j.cclet.2023.108928
15. [15]
  Yihan Zhou , Duo Gao , Yaying Wang , Li Liang , Qingyu Zhang , Wenwen Han , Jie Wang , Chunliu Zhu , Xinxin Zhang , Yong Gan . Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108967-. doi: 10.1016/j.cclet.2023.108967
16. [16]
  Zhaomin Tang , Qian He , Jianren Zhou , Shuang Yan , Li Jiang , Yudong Wang , Chenxing Yao , Huangzhao Wei , Keda Yang , Jiajia Wang . Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109742-. doi: 10.1016/j.cclet.2024.109742
17. [17]
  Yu Qin , Mingyang Huang , Chenlu Huang , Hannah L. Perry , Linhua Zhang , Dunwan Zhu . O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma. Chinese Chemical Letters, 2024, 35(7): 109171-. doi: 10.1016/j.cclet.2023.109171
18. [18]
  Yiling Li , Zekun Gao , Xiuxiu Yue , Minhuan Lan , Xiuli Zheng , Benhua Wang , Shuang Zhao , Xiangzhi Song . FRET-based two-photon benzo[a] phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109133-. doi: 10.1016/j.cclet.2023.109133
19. [19]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
20. [20]
  Ling-Ling Wu , Xiangchuan Meng , Qingyang Zhang , Xiaowan Han , Feiya Yang , Qinghua Wang , Hai-Yu Hu , Nianzeng Xing . Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108663-. doi: 10.1016/j.cclet.2023.108663

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(133)
HTML views(4)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142