Citation: Yongkang Yue, Zhou Xu, Kaiqing Ma, Fangjun Huo, Xuemei Qin, Kuanshou Zhang, Caixia Yin. HSA shrinkage optimizes the photostability of embedded dyes fundamentally to amplify their efficiency as photothermal materials[J]. Chinese Chemical Letters, ;2024, 35(8): 109223. doi: 10.1016/j.cclet.2023.109223 shu

HSA shrinkage optimizes the photostability of embedded dyes fundamentally to amplify their efficiency as photothermal materials

Yongkang Yue ^a ,
Zhou Xu ^{a, b} ,
Kaiqing Ma ^a ,
Fangjun Huo ^c ,
Xuemei Qin ^b ,
Kuanshou Zhang ^d ,
Caixia Yin ^{a, *,}

a.
Department Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
b.
Department Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
c.
Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China
d.
State Key Laboratory of Quantum Optics and Quantum Optics Devices, Institute of Opto-Electronics, Shanxi University, Taiyuan 030006, China

yincx@sxu.edu.cn

Received Date: 11 August 2023
Revised Date: 15 October 2023
Accepted Date: 19 October 2023
Available Online: 20 October 2023

Figures(5)

Focused on the performance promotion of organic small molecular dyes based photothermal agents via non-chemical modification, we found that heat-assisted binding of human serum albumin (HSA) to the dye causes shrinkage of the protein and encapsulate the dye to form nanoparticles. This revolutionizes the photostability of small molecule dyes which further improves their photothermal conversion efficiency and tumor ablation performance as photothermal agents significantly. In this work, the obtained photothermal agent named HSA-P2-T could accumulate in tumor and induce 22 ℃ enhancement of the tumor in xenograft models upon ultra-low dose (0.1 W/cm²) laser irradiation, which, as far as we know, is the lowest laser dose used in vivo photothermal therapy. Utilizing HSA-P2-T, we realized tumor ablation upon twice intravenous injections of the nanoparticles and four photothermal treatments.
- Photothermal therapy,
- Cyanine dyes,
- Photostability,
- Albumin,
- Encapsulation
1. [1]
  Y. Liu, P. Bhattarai, Z. Dai, X. Chen, Chem. Soc. Rev. 48 (2019) 2053–2108. doi: 10.1039/C8CS00618K
2. [2]
  Z. Xie, T. Fan, J. An, et al., Chem. Soc. Rev. 49 (2020) 8065–8087. doi: 10.1039/d0cs00215a
3. [3]
  M. Ferrari, Nat. Rev. Cancer 5 (2005) 161–171. doi: 10.1038/nrc1566
4. [4]
  H. Si, D. Wang, X. Du, X. Zhou, Chin. Chem. Lett. 35 (2024) 108595. doi: 10.1016/j.cclet.2023.108595
5. [5]
  L. Wang, A. Mei, N. Li, et al., Chin. Chem. Lett. 35 (2024) 108974. doi: 10.1016/j.cclet.2023.108974
6. [6]
  H.S. Jung, P. Verwilst, A. Sharma, et al., Chem. Soc. Rev. 47 (2018) 2280–2297. doi: 10.1039/c7cs00522a
7. [7]
  J. Liu, J. Shi, W. Nie, et al., Adv. Healthc. Mater. 10 (2021) 2001207. doi: 10.1002/adhm.202001207
8. [8]
  K.X. Teng, W.K. Chen, L.Y. Niu, et al., Angew. Chem. Int. Ed. 60 (2021) 19912–19920. doi: 10.1002/anie.202106748
9. [9]
  G. Feng, G.Q. Zhang, D. Ding, Chem. Soc. Rev. 49 (2020) 8179–8234. doi: 10.1039/d0cs00671h
10. [10]
  C. Xu, K. Pu, Chem. Soc. Rev. 50 (2021) 1111–1137. doi: 10.1039/d0cs00664e
11. [11]
  L.R. Hirsch, R.J. Stafford, J.A. Bankson, et al., Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 13549–13554. doi: 10.1073/pnas.2232479100
12. [12]
  D.P. O’Neal, L.R. Hirsch, N.J. Halas, J.D. Payne, J.L. West, Cancer Lett. 209 (2004) 171–176. doi: 10.1016/j.canlet.2004.02.004
13. [13]
  B. Zhou, Y. Li, G. Niu, et al., ACS Appl. Mater. Interfaces 8 (2016) 29899–29905. doi: 10.1021/acsami.6b07838
14. [14]
  L. Zou, H. Wang, B. He, et al., Theranostics 6 (2016) 762–772. doi: 10.7150/thno.14988
15. [15]
  M. Xing, Y. Han, Y. Zhu, et al., Anal. Chem. 94 (2022) 12836–12844. doi: 10.1021/acs.analchem.2c02798
16. [16]
  G. Yang, P. Li, Y. Han, et al., Mater. Chem. Phys. 295 (2023) 127145. doi: 10.1016/j.matchemphys.2022.127145
17. [17]
  L. Tang, P. Li, Y. Han, et al., J. Photochem. Photobiol. A: Chem. 438 (2023) 114511. doi: 10.1016/j.jphotochem.2022.114511
18. [18]
  H. Xin, Y. Huang, Y. Han, et al., Spectrochim. Acta Part A: Mol. Biomol. Spectrosc. 299 (2023) 122876. doi: 10.1016/j.saa.2023.122876
19. [19]
  J.H.M. Van Der Velde, J. Oelerich, J. Huang, et al., Nat. Commun. 7 (2016) 10144. doi: 10.1038/ncomms10144
20. [20]
  Z. Lei, F. Zhang, Angew. Chem. Int. Ed. 60 (2021) 16294–16308. doi: 10.1002/anie.202007040
21. [21]
  P. Cheng, K. Pu, Nat. Rev. Mater. 6 (2021) 1095–1113. doi: 10.1038/s41578-021-00328-6
22. [22]
  A.N. Butkevich, M.L. Bossi, G. Lukinavičius, S.W. Hell, J. Am. Chem. Soc. 141 (2019) 981–989. doi: 10.1021/jacs.8b11036
23. [23]
  Y. Yue, T. Zhao, Y. Wang, et al., Chem. Sci. 13 (2022) 218–224. doi: 10.1039/d1sc05484h
24. [24]
  Y. Fan, F. Wang, F. Hou, et al., Chin. Chem. Lett. 34 (2023) 107557. doi: 10.1016/j.cclet.2022.05.071
25. [25]
  S. Gao, G. Wei, S. Zhang, et al., Nat. Commun. 10 (2019) 2206. doi: 10.1038/s41467-019-10056-9
26. [26]
  R. Tian, Q. Zeng, S. Zhu, et al., Sci. Adv. 5 (2019) eaaw0672. doi: 10.1126/sciadv.aaw0672
27. [27]
  Y. Yue, T. Zhao, Z. Xu, et al., Adv. Sci. 10 (2023) 2205080. doi: 10.1002/advs.202205080
28. [28]
  Q. Chen, Z. Liu, Adv. Mater. 28 (2016) 10557–10566. doi: 10.1002/adma.201600038
29. [29]
  Z. Liu, X. Chen, Chem. Soc. Rev. 45 (2016) 1432–1456. doi: 10.1039/C5CS00158G
30. [30]
  H. Gu, W. Liu, W. Sun, et al., Chem. Sci. 13 (2022) 9719–9726. doi: 10.1039/d2sc02879d
31. [31]
  J. Zielonka, J. Joseph, A. Sikora, et al., Chem. Rev. 117 (2017) 10043–10120. doi: 10.1021/acs.chemrev.7b00042
32. [32]
  J. Kadkhoda, A. Tarighatnia, N.D. Nader, A. Aghanejad, Life Sci. 307 (2022) 120898. doi: 10.1016/j.lfs.2022.120898
33. [33]
  Z. Luo, T. Lv, K. Zhu, et al., Angew. Chem. Int. Ed. 59 (2020) 3131–3136. doi: 10.1002/anie.201915046
34. [34]
  I. Petitpas, A.A. Bhattacharya, S. Twine, M. East, S. Curry, J. Biol. Chem. 276 (2001) 22804–22809. doi: 10.1074/jbc.M100575200
35. [35]
  G. Rabbani, S.N. Ahn, Int. J. Biol. Macromol. 123 (2019) 979–990. doi: 10.1016/j.ijbiomac.2018.11.053
36. [36]
  F. Yang, C. Bian, L. Zhu, et al., J. Struct. Biol. 157 (2007) 348–355. doi: 10.1016/j.jsb.2006.08.015
37. [37]
  H. Alsamamra, K. Kh, S. Darwish, M. Abuteir, J. Med. Physiol. Biophys. 49 (2018) 1–8.
38. [38]
  K. Qian, H. Chen, C. Qu, et al., Nanomed. Nanotechnol. Biol. Med. 23 (2020) 102087. doi: 10.1016/j.nano.2019.102087
39. [39]
  G. Battogtokh, Y.T. Ko, Nanomed. Nanotechnol. Biol. Med. 13 (2017) 733–743. doi: 10.1016/j.nano.2016.10.014
40. [40]
  S. Li, G. Zhang, Y. Peng, et al., Adv. Healthc. Mater. 12 (2023) 2300327. doi: 10.1002/adhm.202300327
41. [41]
  W. Sun, S. Guo, C. Hu, J. Fan, X. Peng, Chem. Rev. 116 (2016) 7768–7817. doi: 10.1021/acs.chemrev.6b00001
42. [42]
  D. Xi, N. Xu, X. Xia, et al., Adv. Mater. 34 (2022) 2106797. doi: 10.1002/adma.202106797
43. [43]
  W. Bian, Y. Wang, Z. Pan, et al., ACS Appl. Nano Mater. 4 (2021) 11353–11385. doi: 10.1021/acsanm.1c01903
44. [44]
  D. Xi, M. Xiao, J. Cao, et al., Adv. Mater. 32 (2020) 1907855. doi: 10.1002/adma.201907855
45. [45]
  H. Dai, Z. Cheng, T. Zhang, et al., Chin. Chem. Lett. 33 (2022) 2501–2506. doi: 10.1016/j.cclet.2021.11.079
46. [46]
  A.M. Smith, M.C. Mancini, S. Nie, Nat. Nanotechnol. 4 (2009) 710–711. doi: 10.1038/nnano.2009.326
47. [47]
  J. Cao, B. Zhu, K. Zheng, et al., Front. Bioeng. Biotechnol. 7 (2020) 487. doi: 10.3389/fbioe.2019.00487
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