Citation: Rui Wang, He Qi, Haijiao Zheng, Qiong Jia. Light/pH dual-responsive magnetic metal-organic frameworks composites for phosphorylated peptide enrichment[J]. Chinese Chemical Letters, ;2024, 35(7): 109215. doi: 10.1016/j.cclet.2023.109215 shu

Light/pH dual-responsive magnetic metal-organic frameworks composites for phosphorylated peptide enrichment

Rui Wang ^{a, 1} ,
He Qi ^{a, 1} ,
Haijiao Zheng ^a ,
Qiong Jia ^{a, b, *,}

a.
College of Chemistry, Jilin University, Changchun 130012, China
b.
Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China

jiaqiong@jlu.edu.cn

Received Date: 28 June 2023
Revised Date: 19 September 2023
Accepted Date: 15 October 2023
Available Online: 21 October 2023

Figures(5)

Metal-organic frameworks (MOFs) combined with specific ligands are highly adaptable smart materials that can respond to external and physiological stimuli. In this study, we introduced a pyridinyl zwitterionic ligand with light/pH dual response into magnetic MOF composite (Fe₃O₄@ZW-MOF) for enrichment of phosphorylated peptides for the first time. The introduction of the developed ligand gives MOF material dual response properties. Light stimulation affects the generation/disappearance of free radicals of the pyridine derivative, resulting in a change in the charge gradient of the zwitterion, and zwitterion can also regulate the pH of the solution by adding acid or base. Therefore, the reversible capture and release of phosphorylated peptides can be easily achieved by adjusting light and pH. The established phosphorylated peptide enrichment platform exhibits high sensitivity (detection limit of 1 fmol), high selectivity (β-casein: BSA, 1:1000), and good reusability (7 cycles). In addition, the method was applied to the enrichment of phosphorylated peptides in complex systems (non-fat milk and human serum), demonstrating the feasibility of this method for phosphoproteom analysis. In conclusion, the synthesized Fe₃O₄@ZW-MOF is a promising MOF material, which provides the possibility to advance the application of responsive MOFs materials in proteomics.
- Light,
- pH,
- Dual-response,
- Metal-organic frameworks,
- Phosphorylated peptide
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