Citation: Zhe Li, Ping-Zhao Liang, Li Xu, Fei-Yu Yang, Tian-Bing Ren, Lin Yuan, Xia Yin, Xiao-Bing Zhang. Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy[J]. Chinese Chemical Letters, ;2024, 35(8): 109190. doi: 10.1016/j.cclet.2023.109190 shu

Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

rentianbing@hnu.edu.cn

xbzhang@hnu.edu.cn

Received Date: 9 August 2023
Revised Date: 28 September 2023
Accepted Date: 7 October 2023
Available Online: 14 October 2023

Figures(4)

Photodynamic therapy (PDT) has emerged as a significant cancer therapy option. Currently, cation-based organic small molecule aggregation-induced emission (AIE) photosensitizers (PSs) attract the wide attention of many scientists, due to improved reactive oxygen species (ROS) production after cationization. However, such PSs tend to localize only the mitochondria, limiting the death way of tumor cells (usually apoptosis) during PDT process, which may affect the therapeutic effect under some circumstances. Herein, we designed a novel water-soluble three positive charge PS, TPAN-18F, which could be distributed uniformly in cell cytoplasm and had distribution in different sub-organelles (mitochondria, endoplasmic reticulum, lysosome). The experimental results showed that TPAN-18F-based PDT process can not only disrupt mitochondrial functions (reducing ATP production and destroying mitochondrial membrane potential), but also elevate the intracellular lipid peroxides (LPOs) level, which evoke the non-apoptotic death manner of tumor cells. Further, in vivo studies showed that TPAN-18F-based PDT could effectively inhibit tumor growth. Accordingly, we believe that the construction of TPAN-18F is suggestive for tumor non-apoptotic therapy.
- Water-soluble,
- Three positive charge,
- Photosensitizer,
- Nonapoptotic,
- Tumor therapy
1. [1]
  H.W. Liu, L. Chen, C. Xu, et al., Chem. Soc. Rev. 47 (2018) 7140–7180. doi: 10.1039/c7cs00862g
2. [2]
  Z. Hu, C. Fang, B. Li, Z. Zhang, et al., Nat. Biomed. Eng. 4 (2019) 259–271. doi: 10.1038/s41551-019-0494-0
3. [3]
  C. Wang, W. Fan, Z. Zhang, et al., Adv. Mater. 31 (2019) 1904329. doi: 10.1002/adma.201904329
4. [4]
  C. Li, Y. Pang, Y. Xu, et al., Chem. Soc. Rev. 52 (2023) 4392–4442. doi: 10.1039/d3cs00227f
5. [5]
  A.B. Chagpar, R.C. Martin, L.J. Hagendoorn, C. Chao, K.M. McMasters, Am. J. Surg. 188 (2004) 399–402. doi: 10.1016/j.amjsurg.2004.06.020
6. [6]
  M.C. Smitt, K. Horst, Ann. Surg. Oncol. 14 (2007) 1040–1044. doi: 10.1245/s10434-006-9308-1
7. [7]
  S. Gioux, H.S. Choi, J.V. Frangioni, Mol. Imaging 9 (2010) 237–255.
8. [8]
  M. Rizzo, R. Iyengar, S.G. Gabram, et al., Ann. Surg. Oncol. 17 (2010) 228–234. doi: 10.1245/s10434-009-0643-x
9. [9]
  A.L. Vahrmeijer, M. Hutteman, J.R. van der Vorst, C.J. van de Velde, J.V. Frangioni, Nat. Rev. Clin. Oncol. 10 (2013) 507–518. doi: 10.1038/nrclinonc.2013.123
10. [10]
  S. Liu, L. Luo, L. Zhao, et al., Nat. Commun. 12 (2021) 4014. doi: 10.1038/s41467-021-24288-1
11. [11]
  C. Yang, G. Song, H. Yuan, et al., CCS Chem. 3 (2021) 1116–1128. doi: 10.31635/ccschem.020.202000188
12. [12]
  Y. Xu, C. Li, J. An, et al., Sci. China Chem. 66 (2022) 155–163.
13. [13]
  J. Yuan, Q.H. Zhou, S. Xu, et al., Angew. Chem. Int. Ed. 61 (2022) e202206169. doi: 10.1002/anie.202206169
14. [14]
  Z. Li, P.Z. Liang, L. Xu, et al., Nat. Commun. 14 (2023) 1843. doi: 10.1038/s41467-023-37586-7
15. [15]
  H. Zhu, K. Ma, R. Ruan, et al., Chin. Chem. Lett. 35 (2024) 108536. doi: 10.1016/j.cclet.2023.108536
16. [16]
  J. Mei, N.L.C. Leung, R.T.K. Kwok, J.W.Y. Lam, B.Z. Tang, Chem. Rev. 115 (2015) 11718–11940. doi: 10.1021/acs.chemrev.5b00263
17. [17]
  G. Hong, A.L. Antaris, H. Dai, Nat. Biomed. Eng. 1 (2017) 0010. doi: 10.1038/s41551-016-0010
18. [18]
  P. Lu, X. Zhang, T. Ren, L. Yuan, Chin. Chem. Lett. 31 (2020) 2980–2984. doi: 10.1016/j.cclet.2020.08.016
19. [19]
  S. Wang, W.X. Ren, J.T. Hou, et al., Chem. Soc. Rev. 50 (2021) 8887–8902. doi: 10.1039/d1cs00083g
20. [20]
  X. Zhang, T. Ren, F. Yang, L. Yuan, Chin. Chem. Lett. 32 (2021) 3890–3894. doi: 10.1016/j.cclet.2021.06.038
21. [21]
  H. Li, H. Kim, F. Xu, et al., Chem. Soc. Rev. 51 (2022) 1795–1835. doi: 10.1039/d1cs00307k
22. [22]
  Z. Li, P.Z. Liang, T.B. Ren, L. Yuan, X.B. Zhang, Angew. Chem. Int. Ed. 62 (2023) e202305742. doi: 10.1002/anie.202305742
23. [23]
  X. Zhang, F. Yang, T. Ren, et al., Chin. Chem. Lett. 34 (2023) 107835. doi: 10.1016/j.cclet.2022.107835
24. [24]
  W. Fan, P. Huang, X. Chen, Chem. Soc. Rev. 45 (2016) 6488–6519. doi: 10.1039/C6CS00616G
25. [25]
  X. Li, S. Lee, J. Yoon, Chem. Soc. Rev. 47 (2018) 1174–1188. doi: 10.1039/c7cs00594f
26. [26]
  J. Kou, D. Dou, L. Yang, Oncotarget 8 (2017) 81591–81603. doi: 10.18632/oncotarget.20189
27. [27]
  R.C.H. Wong, P.C. Lo, D.K.P. Ng, Coord. Chem. Rev. 379 (2019) 30–46. doi: 10.1016/j.ccr.2017.10.006
28. [28]
  Z. Liu, H. Zou, Z. Zhao, et al., ACS Nano 13 (2019) 11283–11293. doi: 10.1021/acsnano.9b04430
29. [29]
  C. Gui, E. Zhao, R.T.K. Kwok, et al., Chem. Sci. 8 (2017) 1822–1830. doi: 10.1039/C6SC04947H
30. [30]
  D. Wang, M.M.S. Lee, G. Shan, et al., Adv. Mater. 30 (2018) e1802105. doi: 10.1002/adma.201802105
31. [31]
  D. Wang, H. Su, R.T.K. Kwok, et al., Chem. Sci. 9 (2018) 3685–3693. doi: 10.1039/c7sc04963c
32. [32]
  Y. Gao, X. Wang, X. He, et al., Adv. Funct. Mater. 29 (2019) 1902673. doi: 10.1002/adfm.201902673
33. [33]
  T. Zhang, Y. Li, Z. Zheng, et al., J. Am. Chem. Soc. 141 (2019) 5612–5616. doi: 10.1021/jacs.9b00636
34. [34]
  W. Xu, M.M.S. Lee, J.J. Nie, et al., Angew. Chem. Int. Ed. 59 (2020) 9610–9616. doi: 10.1002/anie.202000740
35. [35]
  Y. Yu, S. Wu, L. Zhang, et al., Biomaterials 280 (2022) 121255. doi: 10.1016/j.biomaterials.2021.121255
36. [36]
  Z. Zheng, H. Liu, S. Zhai, et al., Chem. Sci. 11 (2020) 2494–2503. doi: 10.1039/c9sc06441a
37. [37]
  S. Xu, Y. Yuan, X. Cai, et al., Chem. Sci. 6 (2015) 5824–5830. doi: 10.1039/C5SC01733E
38. [38]
  C. Jiang, X. Li, F. Pan, et al., Adv. Funct. Mater. 33 (2023) 2211698. doi: 10.1002/adfm.202211698
39. [39]
  Z. Dong, P. Liang, G. Guan, et al., Angew. Chem. Int. Ed. 61 (2022) e202206074. doi: 10.1002/anie.202206074
40. [40]
  W. Li, S. Yin, Y. Shen, et al., J. Am. Chem. Soc. 145 (2023) 3736–3747. doi: 10.1021/jacs.2c13222
1. [1]
  Qihan Lin , Jiabin Xing , Yue-Yang Liu , Gang Wu , Shi-Jia Liu , Hui Wang , Wei Zhou , Zhan-Ting Li , Dan-Wei Zhang . taBOX: A water-soluble tetraanionic rectangular molecular container for conjugated molecules and taste masking for berberine and palmatine. Chinese Chemical Letters, 2024, 35(5): 109119-. doi: 10.1016/j.cclet.2023.109119
2. [2]
  Yiling Li , Zekun Gao , Xiuxiu Yue , Minhuan Lan , Xiuli Zheng , Benhua Wang , Shuang Zhao , Xiangzhi Song . FRET-based two-photon benzo[a] phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109133-. doi: 10.1016/j.cclet.2023.109133
3. [3]
  Tao LIU , Yuting TIAN , Ke GAO , Xuwei HAN , Ru'nan MIN , Wenjing ZHAO , Xueyi SUN , Caixia YIN . A photothermal agent with high photothermal conversion efficiency and high stability for tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1622-1632. doi: 10.11862/CJIC.20240107
4. [4]
  Fengyun Li , Zerong Pei , Shuting Chen , Gen li , Mengyang Liu , Liqin Ding , Jingbo Liu , Feng Qiu . Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid. Chinese Chemical Letters, 2024, 35(5): 108752-. doi: 10.1016/j.cclet.2023.108752
5. [5]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
6. [6]
  An Lu , Yuhao Guo , Yi Yan , Lin Zhai , Xiangyu Wang , Weiran Cao , Zijie Li , Zhixia Zhao , Yujie Shi , Yuanjun Zhu , Xiaoyan Liu , Huining He , Zhiyu Wang , Jian-Cheng Wang . Nanomedicine integrating the lipidic derivative of 5-fluorouracil, miriplatin and PD-L1 siRNA for enhancing tumor therapy. Chinese Chemical Letters, 2024, 35(6): 108928-. doi: 10.1016/j.cclet.2023.108928
7. [7]
  Ji Liu , Dongsheng He , Tianjiao Hao , Yumin Hu , Yan Zhao , Zhen Li , Chang Liu , Daquan Chen , Qiyue Wang , Xiaofei Xin , Yan Shen . Gold mineralized "hybrid nanozyme bomb" for NIR-II triggered tumor effective permeation and cocktail therapy. Chinese Chemical Letters, 2024, 35(9): 109296-. doi: 10.1016/j.cclet.2023.109296
8. [8]
  Wenjuan Jin , Zelong Chen , Yi Wang , Jiaxuan Li , Jiahui Li , Yuxin Pei , Zhichao Pei . Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy. Chinese Chemical Letters, 2024, 35(7): 109328-. doi: 10.1016/j.cclet.2023.109328
9. [9]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254
10. [10]
  Zhaomin Tang , Qian He , Jianren Zhou , Shuang Yan , Li Jiang , Yudong Wang , Chenxing Yao , Huangzhao Wei , Keda Yang , Jiajia Wang . Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109742-. doi: 10.1016/j.cclet.2024.109742
11. [11]
  Lixian Fu , Yiyun Tan , Yue Ding , Weixia Qing , Yong Wang . Water–soluble and polarity–sensitive near–infrared fluorescent probe for long–time specific cancer cell membranes imaging and C. Elegans label. Chinese Chemical Letters, 2024, 35(4): 108886-. doi: 10.1016/j.cclet.2023.108886
12. [12]
  Lishan Xiong , Xinyuan Li , Xiaojie Lu , Zhendong Zhang , Yan Zhang , Wen Wu , Chenhui Wang . Inhaled multilevel size-tunable, charge-reversible and mucus-traversing composite microspheres as trojan horse: Enhancing lung deposition and tumor penetration. Chinese Chemical Letters, 2024, 35(9): 109384-. doi: 10.1016/j.cclet.2023.109384
13. [13]
  Kai Han , Guohui Dong , Ishaaq Saeed , Tingting Dong , Chenyang Xiao . Boosting bulk charge transport of CuWO4 photoanodes via Cs doping for solar water oxidation. Chinese Journal of Structural Chemistry, 2024, 43(2): 100207-100207. doi: 10.1016/j.cjsc.2023.100207
14. [14]
  Han Han , Bi-Te Chen , Jia-Rong Ding , Jin-Ming Si , Tian-Jiao Zhou , Yi Wang , Lei Xing , Hu-Lin Jiang . A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy. Chinese Chemical Letters, 2024, 35(10): 109583-. doi: 10.1016/j.cclet.2024.109583
15. [15]
  Xiaohong Wen , Mei Yang , Lie Li , Mingmin Huang , Wei Cui , Suping Li , Haiyan Chen , Chen Li , Qiuping Guo . Enzymatically controlled DNA tetrahedron nanoprobes for specific imaging of ATP in tumor. Chinese Chemical Letters, 2024, 35(8): 109291-. doi: 10.1016/j.cclet.2023.109291
16. [16]
  Yi Cao , Xiaojiao Ge , Yuanyuan Wei , Lulu He , Aiguo Wu , Juan Li . Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition. Chinese Chemical Letters, 2024, 35(4): 108672-. doi: 10.1016/j.cclet.2023.108672
17. [17]
  Fang-Yuan Chen , Wen-Chao Geng , Kang Cai , Dong-Sheng Guo . Molecular recognition of cyclophanes in water. Chinese Chemical Letters, 2024, 35(5): 109161-. doi: 10.1016/j.cclet.2023.109161
18. [18]
  Ling Yang , Min Ren , Jie Wang , Liming He , Shanshan Wu , Shuai Yang , Wei Zhao , Hao Cheng , Xiaoming Zhou , Maling Gou . A non-viral gene therapy for melanoma by staphylococcal enterotoxin A. Chinese Chemical Letters, 2024, 35(5): 108822-. doi: 10.1016/j.cclet.2023.108822
19. [19]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
20. [20]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(176)
HTML views(3)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142