Citation: Hui-Juan Wang, Wen-Wen Xing, Zhen-Hai Yu, Yong-Xue Li, Heng-Yi Zhang, Qilin Yu, Hongjie Zhu, Yao-Yao Wang, Yu Liu. Cucurbit[7]uril confined phenothiazine bridged bis(bromophenyl pyridine) activated NIR luminescence for lysosome imaging[J]. Chinese Chemical Letters, ;2024, 35(6): 109183. doi: 10.1016/j.cclet.2023.109183 shu

Cucurbit[7]uril confined phenothiazine bridged bis(bromophenyl pyridine) activated NIR luminescence for lysosome imaging

Hui-Juan Wang ^{a, b, 1} ,
Wen-Wen Xing ^{a, 1} ,
Zhen-Hai Yu ^a ,
Yong-Xue Li ^a ,
Heng-Yi Zhang ^a ,
Qilin Yu ^c ,
Hongjie Zhu ^b ,
Yao-Yao Wang ^b ,
Yu Liu ^{a, *,}

a.
College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
b.
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, China
c.
Key Laboratory of Molecular Microbiology and Technology, College of Life Sciences, Nankai University, Tianjin 300071, China

yuliu@nankai.edu.cn

Received Date: 27 July 2023
Revised Date: 27 September 2023
Accepted Date: 7 October 2023
Available Online: 10 October 2023

Figures(6)

Macrocycle confinement induced guest near-infrared (NIR) luminescence was research hotspot currently. Here in, we reported a cucurbit[7]uril (CB[7]) confined 3,7-bis((E)-2-(pyridin-4-yl)vinyl)-10-H-phenothiazine bridged bis(4-(4-bromophenyl)pyridine) (G), which not only boosted its NIR luminescence but also realized detection of HClO/ClO⁻ in living cells and lysosome imaging. Fluorescence spectroscopy experiments were performed to calculate the detection ability of probe G to HClO/ClO⁻ up to 147 nmol/L. As compared with G, supramolecular probe G⊂CB[7] formed after encapsulated by CB[7], the detection ability towards HClO/ClO⁻ was improved to 24 nmol/L which was ascribe to the macrocycle CB[7] confinement increasing the fluorescence intensity to 103 folds. Accompanying the excitation wavelength changing, the fluorescence red-shifted to 820 nm when excited by 570 nm light, which was used to NIR lysosome imaging. Meanwhile, the supramolecular assembly G⊂CB[7] was also successfully used to highly sense to exogenous HClO/ClO⁻ in RAW 264.7 cells and live animal.
- Phenothiazine,
- Supramolecular assembly,
- Macrocycle confined,
- Probe,
- HClO/ClO⁻
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