Citation: Yu Qin, Mingyang Huang, Chenlu Huang, Hannah L. Perry, Linhua Zhang, Dunwan Zhu. O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma[J]. Chinese Chemical Letters, ;2024, 35(7): 109171. doi: 10.1016/j.cclet.2023.109171 shu

O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma

Yu Qin ^{a, 1} ,
Mingyang Huang ^{a, 1} ,
Chenlu Huang ^a ,
Hannah L. Perry ^b ,
Linhua Zhang ^{a, *,} ,
Dunwan Zhu ^{a, *,}

a.
Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
b.
Molecular Sciences Research Hub, Department of Chemistry, White City Campus, Imperial College London, London W12 0BZ, United Kingdom

zhanglinhua@bme.pumc.edu.cn

zhudunwan@bme.pumc.edu.cn

Received Date: 12 July 2023
Revised Date: 26 September 2023
Accepted Date: 5 October 2023
Available Online: 7 October 2023

Figures(4)

Photothermal therapy (PTT) and photodynamic therapy (PDT) have received tremendous attention owing to their great potential for tumor treatment. However, two main issues hamper the antitumor performance of PDT: overexpression of glutathione (GSH) in tumors, which consumes PDT-induced reactive oxygen species (ROS), and hypoxia within the tumor microenvironment. The drawbacks of PTT include uneven temperature distribution and the upregulation of the heat-shock proteins in tumors, both of which result in ineffective treatment. To address these issues, a MnO₂ doped nano-delivery system (HTIM-PMs) was synthesized by one-step self-assembly of disulfide bond bridged copolymers for indocyanine green (ICG) and MnO₂ loading. The surface of polymeric micelles was layered with hyaluronan (HA) and transactivator (TAT) peptides to improve active targeting and increase cell penetration. After internalization, HTIM-PMs showed responsiveness to the tumor microenvironment (acid pH, high glutathione, high H₂O₂). Breaking the disulfide bond reduced the intratumoral GSH level and simultaneously released the MnO₂ and ICG. The released MnO₂ further reduced the GSH level and promoted O₂ generation, thus enhancing the PDT effect. The PTT-mediated hyperthermia accelerated blood flow, which is beneficial for O₂ distribution, and promotes ROS diffusion. These PTT-mediated adjuvant effects further overcame the limitations of PDT and the robust PDT effect in turn compensated for the deficiency of PTT. This promising platform exhibited a significant improvement in the PTT-PDT cancer treatment strategy compared to previously reported nanostructures.
- Photodynamic therapy,
- Photothermal therapy,
- Oxygen generating,
- One-step self-assembly,
- Stimuli-responsive nanoparticles
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

O2-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma

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通讯作者: 陈斌, bchen63@163.com

O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma